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2014-12-05Zeitschriftenartikel DOI: 10.1039/C4RA11289J
Self-assembly of a cholesteryl-modified nucleoside into tubular structures from giant unilamellar vesicles
dc.contributor.authorLosensky, Luisa
dc.contributor.authorChiantia, Salvatore
dc.contributor.authorHolland, Gudrun
dc.contributor.authorLaue, Michael
dc.contributor.authorPetran, Anca
dc.contributor.authorLiebscher, Jürgen
dc.contributor.authorArbuzova, Anna
dc.date.accessioned2018-05-07T18:25:37Z
dc.date.available2018-05-07T18:25:37Z
dc.date.created2015-08-19
dc.date.issued2014-12-05none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/reOIKJ7LBlKHM/PDF/20p3y40IchYFU.pdf
dc.identifier.urihttp://edoc.rki.de/176904/2120
dc.description.abstractWe recently reported the formation of micro- and nanometer thick tubules in a binary system of cholesteryl-modified aminouridine and a phosphatidylcholine in aqueous solution upon cooling from 70 °C to room temperature (Pescador et al., Chem. Commun, 2010, 46, 5358). To better understand the first steps of the tubular self-assembly and the role of the phospholipid, we investigated now morphological changes of phosphatidylcholine giant unilamellar vesicles upon incorporation of the conjugate at room temperature. We observed formation of needle-like structures organized in rosettes or bundles within hours to days depending on the mole fraction of the conjugate and preparation technique. Transmission electron microscopy revealed that the needle-like structures were 100–200 nm thick tubules with the inner lumen diameters of 15–40 nm. The tube self-assembly occurred at room temperature, which is important for further development of biomedical applications.eng
dc.language.isoeng
dc.publisherRobert Koch-Institut, Biologische Sicherheit
dc.subject.ddc610 Medizin
dc.titleSelf-assembly of a cholesteryl-modified nucleoside into tubular structures from giant unilamellar vesicles
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-10040508
dc.identifier.doi10.1039/C4RA11289J
dc.identifier.doihttp://dx.doi.org/10.25646/2045
local.edoc.container-titleRSC Advances
local.edoc.container-textLosensky, L., Chiantia, S., Holland, G., Laue, M., Petran, A., Liebscher, J., Arbuzova, A. Self-assembly of a cholesteryl-modified nucleoside into tubular structures from giant unilamellar vesicles (2015) RSC Advances, 5 (6), pp. 4502-4510.
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://pubs.rsc.org/en/Content/ArticleLanding/2015/RA/C4RA11289J
local.edoc.container-publisher-nameRoyal Society of Chemistry
local.edoc.container-volume5
local.edoc.container-issue6
local.edoc.container-year2015

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