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2015-08-27Zeitschriftenartikel DOI: 10.25646/2057
Transmission patterns of human enterovirus 71 to, from and among European countries, 2003 to 2013
dc.contributor.authorHassel, C.
dc.contributor.authorMirand, A.
dc.contributor.authorLukashev, A.
dc.contributor.authorTerletskaia-Ladwig, E.
dc.contributor.authorFarkas, A.
dc.contributor.authorSchuffenecker, I.
dc.contributor.authorDiedrich, Sabine
dc.contributor.authorHuemer, H. P.
dc.contributor.authorArchimbaud, C.
dc.contributor.authorPeigue-Lafeuille, H.
dc.contributor.authorHenquell, C.
dc.contributor.authorBailly, J.
dc.date.accessioned2018-05-07T18:27:51Z
dc.date.available2018-05-07T18:27:51Z
dc.date.created2015-09-11
dc.date.issued2015-08-27none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/re26le7BpF8UA/PDF/26OTMBISTyh7M.pdf
dc.identifier.urihttp://edoc.rki.de/176904/2132
dc.description.abstractEnterovirus 71 (EV-71) is involved in epidemics of hand, foot, and mouth disease (HFMD) and has been reported to occur with severe neurological complications in eastern and south-east Asia. In other geographical areas, the transmission of this virus is poorly understood. We used large sequence datasets (of the gene encoding the viral protein 1, VP1) and a Bayesian phylogenetic approach to compare the molecular epidemiology and geographical spread patterns of EV-71 subgenogroups B4, B5, C1, C2, and C4 in Europe relative to other parts of the world. For the study, European countries considered were European Union (EU) Member States and Iceland, Norway and Switzerland. Viruses of the B4, B5, and C4 subgenogroups circulate mainly in eastern and south-east Asia. In Europe sporadic introductions of these subgenogroups are observed, however C1 and C2 viruses predominate. The phylogenies showed evidence of multiple events of spread involving C1 and C2 viruses within Europe since the mid-1990s. Two waves of sporadic C2 infections also occurred in 2010 and 2013. The 2007 Dutch outbreak caused by C2 and the occurrence of B5 and C4 infections in the EU between 2004 and 2013 arose while the circulation of C1 viruses was low. A transmission chain involving a C4 virus was traced from Japan to the EU and then further to Canada between 2001 and 2006. Recent events whereby spread of viruses have occurred from, to, and within Europe appear to be involved in the long term survival of EV-71, highlighting the need for enhanced surveillance of this virus.eng
dc.language.isoeng
dc.publisherRobert Koch-Institut, Infektionskrankheiten / Erreger
dc.subjectHumanseng
dc.subjectBayes Theoremeng
dc.subjectMolecular Sequence Dataeng
dc.subjectGenotypeeng
dc.subjectPhylogenyeng
dc.subjectEurope/epidemiologyeng
dc.subjectRNA Viral/geneticseng
dc.subjectPolymorphism Geneticeng
dc.subjectDisease Outbreakseng
dc.subjectMolecular Epidemiologyeng
dc.subjectEuropean Unioneng
dc.subjectSentinel Surveillanceeng
dc.subjectGeographyeng
dc.subjectGenes Viraleng
dc.subjectEnterovirus Infections/epidemiologyeng
dc.subjectEnterovirus Infections/virologyeng
dc.subjectEnterovirus A Human/classificationeng
dc.subjectEnterovirus A Human/geneticseng
dc.subjectEnterovirus A Human/isolation & purificationeng
dc.subjectEnterovirus Infections/transmissioneng
dc.subjectIceland/epidemiologyeng
dc.subjectNorway/epidemiologyeng
dc.subjectSwitzerland/epidemiologyeng
dc.subject.ddc610 Medizin
dc.titleTransmission patterns of human enterovirus 71 to, from and among European countries, 2003 to 2013
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-10040926
dc.identifier.doihttp://dx.doi.org/10.25646/2057
local.edoc.container-titleEuroSurveillance
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=21218
local.edoc.container-publisher-nameECDC
local.edoc.container-volume20
local.edoc.container-issue34
local.edoc.container-year2015

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