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2015-11-11Zeitschriftenartikel DOI: 10.1016/j.ebiom.2015.11.020
Hepatitis E Virus Superinfection and Clinical Progression in Hepatitis B Patients
dc.contributor.authorHoan, Nghiem Xuan
dc.contributor.authorTong, Hoang Van
dc.contributor.authorHecht, Nicole
dc.contributor.authorSy, Bui Tien
dc.contributor.authorMarcinek, Patrick
dc.contributor.authorMeyer, Christian G.
dc.contributor.authorSong, Le Huu
dc.contributor.authorToan, Nguyen Linh
dc.contributor.authorKurreck, Jens
dc.contributor.authorKremsner, Peter G.
dc.contributor.authorBock, Thomas
dc.contributor.authorVelavan, Thirumalaisamy P.
dc.date.accessioned2018-05-07T18:46:53Z
dc.date.available2018-05-07T18:46:53Z
dc.date.created2016-01-13
dc.date.issued2015-11-11none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/reqpYSbEjXm8g/PDF/20eOhz487cFRE.pdf
dc.identifier.urihttp://edoc.rki.de/176904/2235
dc.description.abstractHepatitis E virus (HEV) infection may cause acute hepatitis and lead to hepatic failure in developing and developed countries. We studied HEV seroprevalences in patients with hepatitis B virus (HBV) infection to understand the consequences of HEV superinfection in a Vietnamese population. This cross-sectional study was conducted from 2012 to 2013 and included 1318 Vietnamese patients with HBV-related liver diseases and 340 healthy controls. The case group included patients with acute (n = 26) and chronic hepatitis B (n = 744), liver cirrhosis (n = 160), hepatocellular carcinoma (n = 166) and patients with both liver cirrhosis and hepatocellular carcinoma (n = 222). Anti-HEV IgG and IgM antibodies were assessed in patients and controls by ELISA. HEV-RNA was identified by PCR assays and sequencing. Seroprevalences of anti-HEV IgG among hepatitis B patients and controls were 45% and 31%, respectively (adjusted P = 0.034). Anti-HEV IgM seroprevalences were 11.6% and 4.7% in patients and controls, respectively (adjusted P = 0.005). Seroprevalences were higher among the elder individuals. When stratifying for patient groups, those with liver cirrhosis had the highest anti-HEV IgG (52%) and anti-HEV IgM (19%) seroprevalences. Hepatitis B patients with current HEV infection had abnormal liver function tests compared to patients with past or without HEV infection. One HEV isolate was retrieved from a patient with both liver cirrhosis and hepatocellular carcinoma and identified as HEV genotype 3. This study indicates high prevalences of HEV infection in Vietnamese HBV patients and among healthy individuals and shows that HEV superinfection may influence the outcome and progression of HBV-related liver disease.eng
dc.language.isoeng
dc.publisherRobert Koch-Institut, Infektionskrankheiten / Erreger
dc.subjectHumanseng
dc.subjectRisk Factorseng
dc.subjectTreatment Outcomeeng
dc.subjectDisease Progressioneng
dc.subjectAntiviral Agents/therapeutic useeng
dc.subjectHepacivirus/drug effectseng
dc.subjectHepacivirus/immunologyeng
dc.subjectHepacivirus/pathogenicityeng
dc.subjectHepatitis C Chronic/diagnosiseng
dc.subjectHepatitis C Chronic/drug therapyeng
dc.subjectHepatitis C Chronic/immunologyeng
dc.subjectHepatitis C Chronic/virologyeng
dc.subjectImmunocompromised Hosteng
dc.subjectImmunosuppressive Agents/adverse effectseng
dc.subjectSuperinfectioneng
dc.subject.ddc610 Medizin
dc.titleHepatitis E Virus Superinfection and Clinical Progression in Hepatitis B Patients
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-10042629
dc.identifier.doi10.1016/j.ebiom.2015.11.020
dc.identifier.doihttp://dx.doi.org/10.25646/2160
local.edoc.container-titleEBioMedicine
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://www.sciencedirect.com/science/article/pii/S2352396415302048
local.edoc.container-publisher-nameElsevier
local.edoc.container-volume2
local.edoc.container-issue12
local.edoc.container-year2015

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