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2016-02-11Zeitschriftenartikel DOI: 10.1371/journal.pone.0148258
Long-Term Shedding of Influenza Virus, Parainfluenza Virus, Respiratory Syncytial Virus and Nosocomial Epidemiology in Patients with Hematological Disorders
dc.contributor.authorLehners, Nicola
dc.contributor.authorTabatabai, Julia
dc.contributor.authorPrifert, Christiane
dc.contributor.authorWedde, Marianne
dc.contributor.authorPuthenparambil, Joe
dc.contributor.authorWeissbrich, Benedikt
dc.contributor.authorBiere, Barbara
dc.contributor.authorSchweiger, Brunhilde
dc.contributor.authorEgerer, Gerlinde
dc.contributor.authorSchnitzler, Paul
dc.date.accessioned2018-05-07T18:52:11Z
dc.date.available2018-05-07T18:52:11Z
dc.date.created2016-02-25
dc.date.issued2016-02-11none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/reCq02oQ4rtw/PDF/21VNJZNolddt6.pdf
dc.identifier.urihttp://edoc.rki.de/176904/2264
dc.description.abstractRespiratory viruses are a cause of upper respiratory tract infections (URTI), but can be associated with severe lower respiratory tract infections (LRTI) in immunocompromised patients. The objective of this study was to investigate the genetic variability of influenza virus, parainfluenza virus and respiratory syncytial virus (RSV) and the duration of viral shedding in hematological patients. Nasopharyngeal swabs from hematological patients were screened for influenza, parainfluenza and RSV on admission as well as on development of respiratory symptoms. Consecutive swabs were collected until viral clearance. Out of 672 tested patients, a total of 111 patients (17%) were infected with one of the investigated viral agents: 40 with influenza, 13 with parainfluenza and 64 with RSV; six patients had influenza/RSV or parainfluenza/RSV co-infections. The majority of infected patients (n = 75/111) underwent stem cell transplantation (42 autologous, 48 allogeneic, 15 autologous and allogeneic). LRTI was observed in 48 patients, of whom 15 patients developed severe LRTI, and 13 patients with respiratory tract infection died. Phylogenetic analysis revealed a variety of influenza A(H1N1)pdm09, A(H3N2), influenza B, parainfluenza 3 and RSV A, B viruses. RSV A was detected in 54 patients, RSV B in ten patients. The newly emerging RSV A genotype ON1 predominated in the study cohort and was found in 48 (75%) of 64 RSV-infected patients. Furthermore, two distinct clusters were detected for RSV A genotype ON1, identical RSV G gene sequences in these patients are consistent with nosocomial transmission. Long-term viral shedding for more than 30 days was significantly associated with prior allogeneic transplantation (p = 0.01) and was most pronounced in patients with RSV infection (n = 16) with a median duration of viral shedding for 80 days (range 35–334 days). Long-term shedding of respiratory viruses might be a catalyzer of nosocomial transmission and must be considered for efficient infection control in immunocompromised patients.eng
dc.language.isoeng
dc.publisherRobert Koch-Institut, Infektionskrankheiten / Erreger
dc.subjectHumanseng
dc.subjectFemaleeng
dc.subjectMaleeng
dc.subjectAdulteng
dc.subjectAgedeng
dc.subjectMiddle Agedeng
dc.subjectYoung Adulteng
dc.subjectTime Factorseng
dc.subjectCohort Studieseng
dc.subjectGenotypeeng
dc.subjectPhylogenyeng
dc.subjectSequence Analysis DNAeng
dc.subjectMutationeng
dc.subjectAged 80 and overeng
dc.subjectInfluenza Human/virologyeng
dc.subjectPolymerase Chain Reactioneng
dc.subjectRetrospective Studieseng
dc.subjectCommunicable Disease Controleng
dc.subjectCross Infection/epidemiologyeng
dc.subjectCross Infection/virologyeng
dc.subjectHematologic Diseases/virologyeng
dc.subjectNose/virologyeng
dc.subjectOrthomyxoviridae/metabolismeng
dc.subjectParainfluenza Virus 3 Human/metabolismeng
dc.subjectParamyxoviridae Infections/virologyeng
dc.subjectRespiratory Syncytial Virus Infections/virologyeng
dc.subjectRespiratory Syncytial Viruses/metabolismeng
dc.subjectTransplantation Homologouseng
dc.subjectVirus Sheddingeng
dc.subject.ddc610 Medizin
dc.titleLong-Term Shedding of Influenza Virus, Parainfluenza Virus, Respiratory Syncytial Virus and Nosocomial Epidemiology in Patients with Hematological Disorders
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-10043118
dc.identifier.doi10.1371/journal.pone.0148258
dc.identifier.doihttp://dx.doi.org/10.25646/2189
local.edoc.container-titlePLoS ONE
local.edoc.container-textLehners N, Tabatabai J, Prifert C, Wedde M, Puthenparambil J, Weissbrich B, et al. (2016) Long-Term Shedding of Influenza Virus, Parainfluenza Virus, Respiratory Syncytial Virus and Nosocomial Epidemiology in Patients with Hematological Disorders. PLoS ONE 11(2): e0148258.
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://journals.plos.org/plosone/article?id=10.1371/journal.pone.0148258
local.edoc.container-publisher-namePublic Library of Science
local.edoc.container-volume11
local.edoc.container-issue2
local.edoc.container-year2016

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