Local T/B cooperation in inflamed tissues is supported by T follicular helper-like cells
dc.contributor.author | Van, Dana Vu | |
dc.contributor.author | Beier, Katja C. | |
dc.contributor.author | Pietzke, Lea-Jean | |
dc.contributor.author | Baz, Maysun S. Al | |
dc.contributor.author | Feist, Randi K. | |
dc.contributor.author | Gurka, Stephanie | |
dc.contributor.author | Hamelmann, Eckard | |
dc.contributor.author | Kroczek, Richard | |
dc.contributor.author | Hutloff, Andreas | |
dc.date.accessioned | 2018-05-07T18:54:43Z | |
dc.date.available | 2018-05-07T18:54:43Z | |
dc.date.created | 2016-03-10 | |
dc.date.issued | 2016-02-26 | none |
dc.identifier.other | http://edoc.rki.de/oa/articles/rea9ITb7rIuI/PDF/21evyZaxSUx5g.pdf | |
dc.identifier.uri | http://edoc.rki.de/176904/2278 | |
dc.description.abstract | Autoimmune diseases and other inflammatory conditions are characterized by large lymphocytic tissue infiltrates in which T and B cells can be found in close contact. Here, using a murine airway inflammation model, we compare antigen-specific T and B cells in lung tissue versus lung-draining lymph node. In the lung we identify a B-cell population exhibiting a classical germinal centre phenotype without being organized into ectopic lymphoid tissue. By contrast, classical CXCR5+ Bcl-6+ T follicular helper cells are not present. Nevertheless, lung-infiltrating T cells exhibit follicular helper-like properties including the potential to provide help to naive B cells. The lung tissue is also a survival niche for memory T and B cells remaining in residual peribronchial infiltrates after resolution of inflammation. Collectively, this study shows the importance of T/B cooperation not only in lymph nodes but also in inflamed peripheral tissues for local antibody responses to infection and autoimmunity. | eng |
dc.language.iso | eng | |
dc.publisher | Robert Koch-Institut | |
dc.subject | Animals | eng |
dc.subject | Mice | eng |
dc.subject | Enzyme-Linked Immunosorbent Assay | eng |
dc.subject | Disease Models Animal | eng |
dc.subject | Mice Transgenic | eng |
dc.subject | Lymphoid Tissue/immunology | eng |
dc.subject | Antibody Formation/immunology | eng |
dc.subject | Lung/immunology | eng |
dc.subject | B-Lymphocytes/immunology | eng |
dc.subject | Flow Cytometry | eng |
dc.subject | Autoimmunity/immunology | eng |
dc.subject | Coculture Techniques | eng |
dc.subject | Germinal Center/immunology | eng |
dc.subject | Inflammation | eng |
dc.subject | Lymph Nodes/immunology | eng |
dc.subject | Lymphocyte Cooperation/immunology | eng |
dc.subject | Ovalbumin/toxicity | eng |
dc.subject | Pneumonia/chemically induced | eng |
dc.subject | Pneumonia/immunology | eng |
dc.subject | Proto-Oncogene Proteins c-bcl-6 | eng |
dc.subject | Receptors Antigen | eng |
dc.subject | T-Cell/genetics | eng |
dc.subject | Receptors CXCR5 | eng |
dc.subject | T-Lymphocyte Subsets/immunology | eng |
dc.subject | T-Lymphocytes Helper-Inducer/immunology | eng |
dc.subject.ddc | 610 Medizin | |
dc.title | Local T/B cooperation in inflamed tissues is supported by T follicular helper-like cells | |
dc.type | periodicalPart | |
dc.identifier.urn | urn:nbn:de:0257-10043390 | |
dc.identifier.doi | 10.1038/ncomms10875 | |
dc.identifier.doi | http://dx.doi.org/10.25646/2203 | |
local.edoc.container-title | Nature Communications | |
local.edoc.fp-subtype | Artikel | |
local.edoc.type-name | Zeitschriftenartikel | |
local.edoc.container-type | periodical | |
local.edoc.container-type-name | Zeitschrift | |
local.edoc.container-url | http://www.nature.com/ncomms/2016/160226/ncomms10875/full/ncomms10875.html | |
local.edoc.container-publisher-name | Nature Publishing Group | |
local.edoc.container-volume | 7 | |
local.edoc.container-issue | 10875 | |
local.edoc.container-year | 2016 |