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2016-02-26Zeitschriftenartikel DOI: 10.1038/ncomms10875
Local T/B cooperation in inflamed tissues is supported by T follicular helper-like cells
dc.contributor.authorVan, Dana Vu
dc.contributor.authorBeier, Katja C.
dc.contributor.authorPietzke, Lea-Jean
dc.contributor.authorBaz, Maysun S. Al
dc.contributor.authorFeist, Randi K.
dc.contributor.authorGurka, Stephanie
dc.contributor.authorHamelmann, Eckard
dc.contributor.authorKroczek, Richard
dc.contributor.authorHutloff, Andreas
dc.date.accessioned2018-05-07T18:54:43Z
dc.date.available2018-05-07T18:54:43Z
dc.date.created2016-03-10
dc.date.issued2016-02-26none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/rea9ITb7rIuI/PDF/21evyZaxSUx5g.pdf
dc.identifier.urihttp://edoc.rki.de/176904/2278
dc.description.abstractAutoimmune diseases and other inflammatory conditions are characterized by large lymphocytic tissue infiltrates in which T and B cells can be found in close contact. Here, using a murine airway inflammation model, we compare antigen-specific T and B cells in lung tissue versus lung-draining lymph node. In the lung we identify a B-cell population exhibiting a classical germinal centre phenotype without being organized into ectopic lymphoid tissue. By contrast, classical CXCR5+ Bcl-6+ T follicular helper cells are not present. Nevertheless, lung-infiltrating T cells exhibit follicular helper-like properties including the potential to provide help to naive B cells. The lung tissue is also a survival niche for memory T and B cells remaining in residual peribronchial infiltrates after resolution of inflammation. Collectively, this study shows the importance of T/B cooperation not only in lymph nodes but also in inflamed peripheral tissues for local antibody responses to infection and autoimmunity.eng
dc.language.isoeng
dc.publisherRobert Koch-Institut
dc.subjectAnimalseng
dc.subjectMiceeng
dc.subjectEnzyme-Linked Immunosorbent Assayeng
dc.subjectDisease Models Animaleng
dc.subjectMice Transgeniceng
dc.subjectLymphoid Tissue/immunologyeng
dc.subjectAntibody Formation/immunologyeng
dc.subjectLung/immunologyeng
dc.subjectB-Lymphocytes/immunologyeng
dc.subjectFlow Cytometryeng
dc.subjectAutoimmunity/immunologyeng
dc.subjectCoculture Techniqueseng
dc.subjectGerminal Center/immunologyeng
dc.subjectInflammationeng
dc.subjectLymph Nodes/immunologyeng
dc.subjectLymphocyte Cooperation/immunologyeng
dc.subjectOvalbumin/toxicityeng
dc.subjectPneumonia/chemically inducedeng
dc.subjectPneumonia/immunologyeng
dc.subjectProto-Oncogene Proteins c-bcl-6eng
dc.subjectReceptors Antigeneng
dc.subjectT-Cell/geneticseng
dc.subjectReceptors CXCR5eng
dc.subjectT-Lymphocyte Subsets/immunologyeng
dc.subjectT-Lymphocytes Helper-Inducer/immunologyeng
dc.subject.ddc610 Medizin
dc.titleLocal T/B cooperation in inflamed tissues is supported by T follicular helper-like cells
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-10043390
dc.identifier.doi10.1038/ncomms10875
dc.identifier.doihttp://dx.doi.org/10.25646/2203
local.edoc.container-titleNature Communications
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://www.nature.com/ncomms/2016/160226/ncomms10875/full/ncomms10875.html
local.edoc.container-publisher-nameNature Publishing Group
local.edoc.container-volume7
local.edoc.container-issue10875
local.edoc.container-year2016

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