I-MOVE multicentre case–control study 2010/11 to 2014/15: Is there within-season waning of influenza type/subtype vaccine effectiveness with increasing time since vaccination?
dc.contributor.author | Kissling, Esther | |
dc.contributor.author | Nunes, B. | |
dc.contributor.author | Robertson, C. | |
dc.contributor.author | Valenciano, Marta | |
dc.contributor.author | Reuss, Annicka | |
dc.contributor.author | Larrauri, A. | |
dc.contributor.author | Cohen, J. M. | |
dc.contributor.author | Oroszi, B. | |
dc.contributor.author | Rizzo, C. | |
dc.contributor.author | Machado, Ausenda | |
dc.contributor.author | Pitigoi, Daniela | |
dc.contributor.author | Domegan, L. | |
dc.contributor.author | Paradowska-Stankiewicz, I. | |
dc.contributor.author | Buchholz, Udo | |
dc.contributor.author | Gherasim, A. | |
dc.contributor.author | Daviaud, I. | |
dc.contributor.author | Horváth, Judit K. | |
dc.contributor.author | Bella, A. | |
dc.contributor.author | Lupulescu, E. | |
dc.contributor.author | O'Donnell, J. | |
dc.contributor.author | Korczyńska, M. | |
dc.contributor.author | Moren, A. | |
dc.date.accessioned | 2018-05-07T19:01:12Z | |
dc.date.available | 2018-05-07T19:01:12Z | |
dc.date.created | 2016-05-02 | |
dc.date.issued | 2016-04-21 | none |
dc.identifier.other | http://edoc.rki.de/oa/articles/rebKykK8HZqj2/PDF/27E8gl32B2KMs.pdf | |
dc.identifier.uri | http://edoc.rki.de/176904/2314 | |
dc.description.abstract | Since the 2008/9 influenza season, the I-MOVE multicentre case–control study measures influenza vaccine effectiveness (VE) against medically-attended influenza-like-illness (ILI) laboratory confirmed as influenza. In 2011/12, European studies reported a decline in VE against influenza A(H3N2) within the season. Using combined I-MOVE data from 2010/11 to 2014/15 we studied the effects of time since vaccination on influenza type/subtype-specific VE. We modelled influenza type/subtype-specific VE by time since vaccination using a restricted cubic spline, controlling for potential confounders (age, sex, time of onset, chronic conditions). Over 10,000 ILI cases were included in each analysis of influenza A(H3N2), A(H1N1)pdm09 and B; with 4,759, 3,152 and 3,617 influenza positive cases respectively. VE against influenza A(H3N2) reached 50.6% (95% CI: 30.0–65.1) 38 days after vaccination, declined to 0% (95% CI: -18.1–15.2) from 111 days onwards. At day 54 VE against influenza A(H1N1)pdm09 reached 55.3% (95% CI: 37.9–67.9) and remained between this value and 50.3% (95% CI: 34.8–62.1) until season end. VE against influenza B declined from 70.7% (95% CI: 51.3–82.4) 44 days after vaccination to 21.4% (95% CI: -57.4–60.8) at season end. To assess if vaccination campaign strategies need revising more evidence on VE by time since vaccination is urgently needed. | eng |
dc.language.iso | eng | |
dc.publisher | Robert Koch-Institut, Infektionsepidemiologie | |
dc.subject | Influenza | eng |
dc.subject | influenza virus | eng |
dc.subject | vaccine-preventable diseases | eng |
dc.subject | vaccines and immunisation | eng |
dc.subject.ddc | 610 Medizin | |
dc.title | I-MOVE multicentre case–control study 2010/11 to 2014/15: Is there within-season waning of influenza type/subtype vaccine effectiveness with increasing time since vaccination? | |
dc.type | periodicalPart | |
dc.identifier.urn | urn:nbn:de:0257-10044971 | |
dc.identifier.doi | 10.2807/1560-7917.ES.2016.21.16.30201 | |
dc.identifier.doi | http://dx.doi.org/10.25646/2239 | |
local.edoc.container-title | EuroSurveillance | |
local.edoc.fp-subtype | Artikel | |
local.edoc.type-name | Zeitschriftenartikel | |
local.edoc.container-type | periodical | |
local.edoc.container-type-name | Zeitschrift | |
local.edoc.container-url | http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=21448 | |
local.edoc.container-publisher-name | ECDC | |
local.edoc.container-volume | 21 | |
local.edoc.container-issue | 16 | |
local.edoc.container-year | 2016 |