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2016-07-21Zeitschriftenartikel DOI: 10.1371/journal.pone.0158039
Sepsis Caused by Extended-Spectrum Beta-Lactamase (ESBL)-Positive K. pneumoniae and E. coli: Comparison of Severity of Sepsis, Delay of Anti-Infective Therapy and ESBL Genotype
dc.contributor.authorSakellariou, Christian
dc.contributor.authorGürntke, Stephan
dc.contributor.authorSteinmetz, Ivo
dc.contributor.authorKohler, Christian
dc.contributor.authorPfeifer, Yvonne
dc.contributor.authorGastmeier, Petra
dc.contributor.authorSchwab, Frank
dc.contributor.authorKola, Axel
dc.contributor.authorDeja, Maria
dc.contributor.authorLeistner, Rasmus
dc.date.accessioned2018-05-07T19:10:23Z
dc.date.available2018-05-07T19:10:23Z
dc.date.created2016-08-01
dc.date.issued2016-07-21none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/rewD7DdwM0GEY/PDF/24hzQSHcoqeqo.pdf
dc.identifier.urihttp://edoc.rki.de/176904/2364
dc.description.abstractInfections with extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E) are associated with increased mortality. Outcome differences due to various species of ESBL-E or ESBL genotypes are not well investigated. We conducted a cohort study to assess risk factors for mortality in cases of ESBL-E bacteremia (K. pneumoniae or E. coli) and the risk factors for sepsis with organ failure. All consecutive patients of our institution from 2008 to 2011 with bacteremia due to ESBL-E were included. Basic epidemiological data, underlying comorbidities, origin of bacteremia, severity of sepsis and delay of appropriate anti-infective treatment were collected. Isolates were PCR-screened for the presence of ESBL genes and plasmid-mediated AmpC β-lactamases. Cox proportional hazard regression on mortality and multivariable logistic regression on risk factors for sepsis with organ failure was conducted. 219 cases were included in the analysis: 73.1% due to E. coli, 26.9% due to K. pneumoniae. There was no significant difference in hospital mortality (ESBL-E. coli, 23.8% vs. ESBL-K. pneumoniae 27.1%, p = 0.724). However, the risk of sepsis with organ failure was associated in cases of K. pneumoniae bacteremia (OR 4.5, peng
dc.language.isoeng
dc.publisherRobert Koch-Institut, Infektionskrankheiten / Erreger
dc.subject.ddc610 Medizin
dc.titleSepsis Caused by Extended-Spectrum Beta-Lactamase (ESBL)-Positive K. pneumoniae and E. coli: Comparison of Severity of Sepsis, Delay of Anti-Infective Therapy and ESBL Genotype
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-10045958
dc.identifier.doi10.1371/journal.pone.0158039
dc.identifier.doihttp://dx.doi.org/10.25646/2289
local.edoc.container-titlePLoS ONE
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0158039
local.edoc.container-publisher-namePublic Library of Science
local.edoc.container-volume11
local.edoc.container-issue7
local.edoc.container-year2016

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