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2016-06-06Zeitschriftenartikel DOI: 10.1371/journal.pone.0156929
The Human Antimicrobial Protein Bactericidal/Permeability-Increasing Protein (BPI) Inhibits the Infectivity of Influenza A Virus
dc.contributor.authorPinkenburg, Olaf
dc.contributor.authorMeyer, Torben
dc.contributor.authorBannert, Norbert
dc.contributor.authorNorley, Steven
dc.contributor.authorBolte, Kathrin
dc.contributor.authorCzudai-Matwich, Volker
dc.contributor.authorHerold, Susanne
dc.contributor.authorGessner, André
dc.contributor.authorSchnare, Markus
dc.date.accessioned2018-05-07T19:10:33Z
dc.date.available2018-05-07T19:10:33Z
dc.date.created2016-08-01
dc.date.issued2016-06-06none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/reVURuiI1YyDU/PDF/27HAMXvT8go.pdf
dc.identifier.urihttp://edoc.rki.de/176904/2365
dc.description.abstractIn addition to their well-known antibacterial activity some antimicrobial peptides and proteins (AMPs) display also antiviral effects. A 27 aa peptide from the N-terminal part of human bactericidal/permeability-increasing protein (BPI) previously shown to harbour antibacterial activity inhibits the infectivity of multiple Influenza A virus strains (H1N1, H3N2 and H5N1) the causing agent of the Influenza pneumonia. In contrast, the homologous murine BPI-peptide did not show activity against Influenza A virus. In addition human BPI-peptide inhibits the activation of immune cells mediated by Influenza A virus. By changing the human BPIpeptide to the sequence of the mouse homologous peptide the antiviral activity was completely abolished. Furthermore, the human BPI-peptide also inhibited the pathogenicity of the Vesicular Stomatitis Virus but failed to interfere with HIV and measles virus. Electron microscopy indicate that the human BPI-peptide interferes with the virus envelope and at high concentrations was able to destroy the particles completely.eng
dc.language.isoeng
dc.publisherRobert Koch-Institut, Infektionskrankheiten / Erreger
dc.subject.ddc610 Medizin
dc.titleThe Human Antimicrobial Protein Bactericidal/Permeability-Increasing Protein (BPI) Inhibits the Infectivity of Influenza A Virus
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-10045965
dc.identifier.doi10.1371/journal.pone.0156929
dc.identifier.doihttp://dx.doi.org/10.25646/2290
local.edoc.container-titlePLoS ONE
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0156929
local.edoc.container-publisher-namePublic Library of Science
local.edoc.container-volume7
local.edoc.container-issue6
local.edoc.container-year2016

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