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2016-09-08Zeitschriftenartikel DOI: 10.1371/journal.pntd.0004923
Bacillus cereus Biovar Anthracis Causing Anthrax in Sub-Saharan Africa—Chromosomal Monophyly and Broad Geographic Distribution
dc.contributor.authorAntonation, Kym S.
dc.contributor.authorGrützmacher, Kim
dc.contributor.authorDupke, Susann
dc.contributor.authorMabon, Philip
dc.contributor.authorZimmermann, Fee
dc.contributor.authorLankester, Felix
dc.contributor.authorPeller, Tianna
dc.contributor.authorFeistner, Anna
dc.contributor.authorTodd, Angelique
dc.contributor.authorHerbinger, Ilka
dc.contributor.authorNys, Hélène de
dc.contributor.authorMuyembe-Tamfun, Jean-Jacques
dc.contributor.authorKarhemere, Stomy
dc.contributor.authorWittig, Roman M.
dc.contributor.authorCouacy-Hymann, Emmanuel
dc.contributor.authorGrunow, Roland
dc.contributor.authorCalvignac-Spencer, Sébastien
dc.contributor.authorCorbett, Cindi R.
dc.contributor.authorKlee, Silke
dc.contributor.authorLeendertz, Fabian H.
dc.date.accessioned2018-05-07T19:21:21Z
dc.date.available2018-05-07T19:21:21Z
dc.date.created2016-09-26
dc.date.issued2016-09-08none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/rewB7VHG19uo/PDF/27KZIebm0l8hc.pdf
dc.identifier.urihttp://edoc.rki.de/176904/2424
dc.description.abstractThrough full genome analyses of four atypical Bacillus cereus isolates, designated B. cereus biovar anthracis, we describe a distinct clade within the B. cereus group that presents with anthrax-like disease, carrying virulence plasmids similar to those of classic Bacillus anthracis. We have isolated members of this clade from different mammals (wild chimpanzees, gorillas, an elephant and goats) in West and Central Africa (Côte d’Ivoire, Cameroon, Central African Republic and Democratic Republic of Congo). The isolates shared several phenotypic features of both B. anthracis and B. cereus, but differed amongst each other in motility and their resistance or sensitivity to penicillin. They all possessed the same mutation in the regulator gene plcR, different from the one found in B. anthracis, and in addition, carry genes which enable them to produce a second capsule composed of hyaluronic acid. Our findings show the existence of a discrete clade of the B. cereus group capable of causing anthrax-like disease, found in areas of high biodiversity, which are possibly also the origin of the worldwide distributed B. anthracis. Establishing the impact of these pathogenic bacteria on threatened wildlife species will require systematic investigation. Furthermore, the consumption of wildlife found dead by the local population and presence in a domestic animal reveal potential sources of exposure to humans.eng
dc.language.isoeng
dc.publisherRobert Koch-Institut, Biologische Sicherheit
dc.subject.ddc610 Medizin
dc.titleBacillus cereus Biovar Anthracis Causing Anthrax in Sub-Saharan Africa—Chromosomal Monophyly and Broad Geographic Distribution
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-10046954
dc.identifier.doi10.1371/journal.pntd.0004923
dc.identifier.doihttp://dx.doi.org/10.25646/2349
local.edoc.container-titlePLoS Neglected Tropical Diseases
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0004923
local.edoc.container-publisher-namePublic Library of Science
local.edoc.container-volume10
local.edoc.container-issue9
local.edoc.container-year2016

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