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2017-02-08Zeitschriftenartikel DOI: 10.1371/journal. pone.0171485
Prospective multicenter German study on pulmonary colonization with Scedosporium /Lomentospora species in cystic fibrosis: Epidemiology and new association factors
dc.contributor.authorSchwarz, Carsten
dc.contributor.authorBrandt, Claudia
dc.contributor.authorAntweiler, Elisabeth
dc.contributor.authorKrannich, Alexander
dc.contributor.authorStaab, Doris
dc.contributor.authorSchmitt-Grohé, Sabina
dc.contributor.authorFischer, Rainald
dc.contributor.authorHartl, Dominik
dc.contributor.authorThronicke, Anja
dc.contributor.authorTintelnot, Kathrin
dc.date.accessioned2018-05-07T19:46:57Z
dc.date.available2018-05-07T19:46:57Z
dc.date.created2017-02-23
dc.date.issued2017-02-08none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/reF6ewg1GQPBE/PDF/213oyqtx41q2.pdf
dc.identifier.urihttp://edoc.rki.de/176904/2562
dc.description.abstractBackground: An increasing rate of respiratory colonization and infection in cystic fibrosis (CF) is caused by fungi of the Scedosporium apiospermum species complex or Lomentospora prolificans (Sac-Lp). These fungi rank second among the filamentous fungi colonizing the CF airways, after Aspergillus fumigatus. However, the epidemiology, clinical relevance and risk of pulmonary colonization with Sac-Lp are rarely understood in CF. The objective of the present prospective multicenter study was to study pathogen distribution and determine association factors of pulmonary Sac-Lp colonization in patients with CF. Material and methods: Clinical, microbiological and laboratory data of 161 patients aged 6–59 years with CF in Germany were analyzed for Sac-Lp distribution and association factors. The free statistical software R was utilized to investigate adjusted logistic regression models for association factors. Results: Of the 161 patients included in the study, 74 (56%) were male. The median age of the study cohort was 23 years (interquartile range 13–32 years). 58 patients of the total cohort (36%) were < 18 years old. Adjusted multivariate regression analysis revealed that Sac-Lp colonization was associated with younger age (OR 0.8684, 95%CI: 0.7955–0.9480, peng
dc.language.isoeng
dc.publisherRobert Koch-Institut, Infektionskrankheiten / Erreger
dc.subject.ddc610 Medizin
dc.titleProspective multicenter German study on pulmonary colonization with Scedosporium /Lomentospora species in cystic fibrosis: Epidemiology and new association factors
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-10051345
dc.identifier.doi10.1371/journal. pone.0171485
dc.identifier.doihttp://dx.doi.org/10.25646/2487
local.edoc.container-titlePLoS ONE
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://journals.plos.org/plosone/article?id=10.1371/journal.pone.0171485
local.edoc.container-publisher-namePublic Library of Science
local.edoc.container-volume12
local.edoc.container-issue2
local.edoc.container-year2017

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