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2017-02-23Zeitschriftenartikel DOI: 10.1371/journal.pone.0170791
Vitamin D and mortality: Individual participant data meta-analysis of standardized 25-hydroxyvitamin D in 26916 individuals from a European consortium
dc.contributor.authorGaksch, Martin
dc.contributor.authorJorde, Rolf
dc.contributor.authorGrimnes, Guri
dc.contributor.authorJoakimsen, Ragnar
dc.contributor.authorSchirmer, Henrik
dc.contributor.authorWilsgaard, Tom
dc.contributor.authorMathiesen, Ellisiv B.
dc.contributor.authorNjølstad, Inger
dc.contributor.authorLøchen, Maja-Lisa
dc.contributor.authorMärz, Winfried
dc.contributor.authorKleber, Marcus E.
dc.contributor.authorTomaschitz, Andreas
dc.contributor.authorGrübler, Martin
dc.contributor.authorEiriksdottir, Gudny
dc.contributor.authorGudmundsson, Elias F.
dc.contributor.authorHarris, Tamara B.
dc.contributor.authorCotch, Mary F.
dc.contributor.authorAspelund, Thor
dc.contributor.authorGudnason, Vilmundur
dc.contributor.authorRutters, Femke
dc.contributor.authorBusch, Markus A.
dc.contributor.authorMensink, Gert
dc.contributor.authorScheidt-Nave, Christa
dc.contributor.authorThamm, Michael
dc.contributor.authorPilz, Stefan
dc.date.accessioned2018-05-07T19:47:20Z
dc.date.available2018-05-07T19:47:20Z
dc.date.created2017-02-23
dc.date.issued2017-02-23none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/rew8WbGpP6o/PDF/240CFOzMl4YUw.pdf
dc.identifier.urihttp://edoc.rki.de/176904/2564
dc.description.abstractBackground: Vitamin D deficiency may be a risk factor for mortality but previous meta-analyses lacked standardization of laboratory methods for 25-hydroxyvitamin D (25[OH]D) concentrations and used aggregate data instead of individual participant data (IPD). We therefore performed an IPD meta-analysis on the association between standardized serum 25(OH)D and mortality. Methods: In a European consortium of eight prospective studies, including seven general population cohorts, we used the Vitamin D Standardization Program (VDSP) protocols to standardize 25(OH)D data. Meta-analyses using a one step procedure on IPD were performed to study associations of 25(OH)D with all-cause mortality as the primary outcome, and with cardiovascular and cancer mortality as secondary outcomes. This meta-analysis is registered at ClinicalTrials.gov, number NCT02438488. Findings: We analysed 26916 study participants (median age 61.6 years, 58% females) with a median 25(OH)D concentration of 53.8 nmol/L. During a median follow-up time of 10.5 years, 6802 persons died. Compared to participants with 25(OH)D concentrations of 75 to 99.99 nmol/L, the adjusted hazard ratios (with 95% confidence interval) for mortality in the 25(OH)D groups with 40 to 49.99, 30 to 39.99, andeng
dc.language.isoeng
dc.publisherRobert Koch-Institut, Epidemiologie und Gesundheitsberichterstattung
dc.subject.ddc610 Medizin
dc.titleVitamin D and mortality: Individual participant data meta-analysis of standardized 25-hydroxyvitamin D in 26916 individuals from a European consortium
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-10051365
dc.identifier.doi10.1371/journal.pone.0170791
dc.identifier.doihttp://dx.doi.org/10.25646/2489
local.edoc.container-titlePLoS ONE
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://journals.plos.org/plosone/article?id=10.1371/journal.pone.0170791
local.edoc.container-publisher-namePublic Library of Science
local.edoc.container-volume12
local.edoc.container-issue2
local.edoc.container-year2017

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