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2017-05-22Zeitschriftenartikel DOI: 10.1371/journal.pone.0176311
Parvovirus B19-induced vascular damage in the heart is associated with elevated circulating endothelial microparticles
dc.contributor.authorBachelier, Katrin
dc.contributor.authorBiehl, Susanne
dc.contributor.authorSchwarz, Viktoria
dc.contributor.authorKindermann, Ingrid
dc.contributor.authorKandolf, Reinhard
dc.contributor.authorSauter, Martina
dc.contributor.authorUkena, Christian
dc.contributor.authorYilmaz, Ali
dc.contributor.authorSliwa, Karen
dc.contributor.authorBock, Thomas
dc.contributor.authorKlingel, Karin
dc.contributor.authorBöhm, Michael
dc.date.accessioned2018-05-07T20:09:03Z
dc.date.available2018-05-07T20:09:03Z
dc.date.created2017-06-27
dc.date.issued2017-05-22none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/redxbNpDzwHgs/PDF/2304gKdxE5Tv2.pdf
dc.identifier.urihttp://edoc.rki.de/176904/2682
dc.description.abstractBackground: Diagnosis of viral myocarditis is difficult by clinical criteria but facilitated by detection of inflammation and viral genomes in endomyocardial biopsies. Parvovirus B19 (B19V) targets endothelial cells where viral nucleic acid is exclusively detected in the heart. Microparticles (MPs) are released after cell damage or activation of specific cells. We aimed to investigate whether circulating endothelial MPs (EMPs) in human and experimental models of myocarditis are associated with B19V myocarditis. Methods: MPs were investigated in patients with myocarditis (n = 54), divided into two groups: B19V+ (n = 23) and B19V- (n = 31) and compared with healthy controls (HCTR, n = 25). MPs were also investigated in B19V transgenic mice (B19V-NS1+) and mice infected with coxsackievirus B3 (CVB3). MPs were analyzed with fluorescent activated cell sorting (FACS). Results: In human samples, EMP subpopulation patterns were significantly different in B19V+ compared to B19V- and HCTR (peng
dc.language.isoeng
dc.publisherRobert Koch-Institut, Infektionskrankheiten / Erreger
dc.subject.ddc610 Medizin
dc.titleParvovirus B19-induced vascular damage in the heart is associated with elevated circulating endothelial microparticles
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-10053103
dc.identifier.doi10.1371/journal.pone.0176311
dc.identifier.doihttp://dx.doi.org/10.25646/2607
local.edoc.container-titlePLoS ONE
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://journals.plos.org/plosone/article?id=10.1371/journal.pone.0176311
local.edoc.container-publisher-namePublic Library of Science
local.edoc.container-volume12
local.edoc.container-issue5
local.edoc.container-year2017

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