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2015-06-24Zeitschriftenartikel DOI: 10.1371/journal.pone.0129333
Ebola Virus Disease Outbreak in Isiro, Democratic Republic of the Congo, 2012: Signs and Symptoms, Management and Outcomes
dc.contributor.authorKratz, Thomas
dc.contributor.authorRoddy, Paul
dc.contributor.authorOloma, Antoine Tshomba
dc.contributor.authorJeffs, Benjamin
dc.contributor.authorCiruelo, Diana Pou
dc.contributor.authorRosa, Olimpia de la
dc.contributor.authorBorchert, Matthias
dc.date.accessioned2018-05-07T20:12:24Z
dc.date.available2018-05-07T20:12:24Z
dc.date.created2017-07-12
dc.date.issued2015-06-24none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/reLFT4NBz1hAA/PDF/29rkBkGxYcbeU.pdf
dc.identifier.urihttp://edoc.rki.de/176904/2700
dc.description.abstractData collected during the 2012 Ebola virus disease (EVD) epidemic in the Democratic Republic of the Congo were analysed for clinical signs, symptoms and case fatality of EVD caused by Bundibugyo virus (BDBV), establishment of differential diagnoses, description of medical treatment and evaluation of the quality of clinical documentation. In a quantitative observational prospective study, global epidemiological data from 52 patients (34 patients within the community, 18 patients treated in the Ebola Treatment Centre) were entered anonymously into a database, subsequently matched and analysed. Relevant findings include an over-representation of females among community EVD cases (85.3%) and of community EVD cases in the age group of 15-54 years (82.4%). All ETC patients had fever (55.6% of all 18 ETC patients during their hospital stay) or self-reported fever (88.2% upon admission) at some point of time during their illness. Major symptoms of ETC patients during hospital stay included asthenia (82.4%), anorexia (82.4%), myalgia (70.6%), sore throat/difficulty swallowing (70.6%), arthralgia (76.5%) and nausea (70.6%). Gastrointestinal signs and symptoms (nausea, diarrhoea, vomiting) (76.4%) as well as general pain (94.1%) were frequent in ETC patients. The median duration of EVD was 18 days, while the mean incubation period was 11.3 days. Differential diagnosis of EVD included malaria (28.3%), intestinal parasitosis (10.9%), and infectious syndrome (10.9%). There was also an important variation in clinical evolvement. Quality of documentation was adversely affected by the way patient file contents were transferred from inside to outside the high-risk zone, entailing a mean mismatch value of 27.3% between patient file contents inside vs. outside the high-risk zone. This study adds further description of EVD (frequently non-specific signs and symptoms, non frequent bleeding, a long incubation period, long duration of disease) and emphasizes the need for improving clinical monitoring and documentation in EVD outbreak settings.eng
dc.language.isoeng
dc.publisherRobert Koch-Institut, Biologische Sicherheit
dc.subjectHumanseng
dc.subjectFemaleeng
dc.subjectMaleeng
dc.subjectAdolescenteng
dc.subjectAdulteng
dc.subjectMiddle Agedeng
dc.subjectYoung Adulteng
dc.subjectTime Factorseng
dc.subjectProspective Studieseng
dc.subjectEpidemicseng
dc.subjectDisease Outbreakseng
dc.subjectDiarrhea/epidemiologyeng
dc.subjectMortalityeng
dc.subjectGeographyeng
dc.subjectPregnancyeng
dc.subjectHemorrhagic Fever Ebola/epidemiologyeng
dc.subjectBody Temperatureeng
dc.subjectDemocratic Republic of the Congo/epidemiologyeng
dc.subjectDiagnosis Differentialeng
dc.subjectEbolaviruseng
dc.subjectFever/epidemiologyeng
dc.subjectHemorrhagic Fever Ebola/mortalityeng
dc.subjectMalaria/complicationseng
dc.subjectNausea/epidemiologyeng
dc.subjectVomiting/epidemiologyeng
dc.subject.ddc610 Medizin
dc.titleEbola Virus Disease Outbreak in Isiro, Democratic Republic of the Congo, 2012: Signs and Symptoms, Management and Outcomes
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-10053336
dc.identifier.doi10.1371/journal.pone.0129333
dc.identifier.doihttp://dx.doi.org/10.25646/2625
local.edoc.container-titlePLoS ONE
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://journals.plos.org/plosone/article/authors?id=10.1371/journal.pone.0129333
local.edoc.container-publisher-namePublic Library of Science
local.edoc.container-volume10
local.edoc.container-issue6
local.edoc.container-year2015

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