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2017-06-23Zeitschriftenartikel DOI: 10.1016/j.ijpddr.2017.06.001
Reduced efficacy of albendazole against Ascaris lumbricoides in Rwandan schoolchildren
dc.contributor.authorKrücken, Jürgen
dc.contributor.authorFraundorfer, Kira
dc.contributor.authorMugisha, Jean Claude
dc.contributor.authorRamünke, Sabrina
dc.contributor.authorSifft, Kevin C.
dc.contributor.authorGeus, Dominik
dc.contributor.authorHabarugira, Felix
dc.contributor.authorNdoli, Jules
dc.contributor.authorSendegeya, Augustin
dc.contributor.authorMukampunga, Caritas
dc.contributor.authorBayingana, Claude
dc.contributor.authorAebischer, Toni
dc.contributor.authorDemeler, Janina
dc.contributor.authorGahutu, Jean Bosco
dc.contributor.authorMockenhaupt, Frank P.
dc.contributor.authorSamson-Himmelstjerna, Georg von
dc.date.accessioned2018-05-07T20:17:27Z
dc.date.available2018-05-07T20:17:27Z
dc.date.created2017-07-19
dc.date.issued2017-06-23none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/reeZcEnu6s6P2/PDF/23bSWXEWfzqEk.pdf
dc.identifier.urihttp://edoc.rki.de/176904/2727
dc.description.abstractControl of human soil-transmitted helminths (STHs) relies on preventive chemotherapy of schoolchildren applying the benzimidazoles (BZ) albendazole or mebendazole. Anthelmintic resistance (AR) is a common problem in nematodes of veterinary importance but for human STHs, information on drug efficacy is limited and routine monitoring is rarely implemented. Herein, the efficacy of single dose albendazole (400 mg) was evaluated in 12 schools in the Huye district of Rwanda where Ascaris is the predominant STH. Ascaris eggs were detected by wet mount microscopy and the Mini-FLOTAC method to assess cure rate (CR) and faecal egg count reduction (FECR). Blood and faecal samples were analysed for co-infections with Plasmodium sp. and Giardia duodenalis, respectively. Ascaris positive samples collected before and after treatment were analysed for putatively BZ-resistance associated β-tubulin gene single nucleotide polymorphisms. The overall CR was 69.9% by Mini-FLOTAC and 88.6% by wet mount microscopy. The FECR was 75.4% and the 95% calculated confidence intervals were 50.4–87.8% using sample variance, 55.4–88.8% by bootstrapping, and 75.0–75.7% applying a Markov Chain Monte Carlo Bayesian approach. FECR varied widely between 0 and 96.8% for individual schools. No putative BZ-resistance associated polymorphisms were found in the four Ascaris β-tubulin isotype genes examined. Since FECRseng
dc.language.isoeng
dc.publisherRobert Koch-Institut, Infektionskrankheiten / Erreger
dc.subjectResistanceeng
dc.subjectSoil-transmitted helmintheng
dc.subjectBenzimidazoleeng
dc.subjectAlbendazoleeng
dc.subjectAscariseng
dc.subjectDewormingeng
dc.subjectTubulineng
dc.subject.ddc610 Medizin
dc.titleReduced efficacy of albendazole against Ascaris lumbricoides in Rwandan schoolchildren
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-10053813
dc.identifier.doi10.1016/j.ijpddr.2017.06.001
dc.identifier.doihttp://dx.doi.org/10.25646/2652
local.edoc.container-titleInternational Journal for Parasitology: Drugs and Drug Resistance
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://www.sciencedirect.com/science/article/pii/S2211320717300337?via%3Dihub
local.edoc.container-publisher-nameElsevier
local.edoc.container-volume7
local.edoc.container-issue3
local.edoc.container-year2017

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