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2017-09-06Zeitschriftenartikel DOI: 10.1186/s12985-017-0836-z
The porcine virome and xenotransplantation
dc.contributor.authorDenner, Joachim
dc.date.accessioned2018-05-07T20:36:35Z
dc.date.available2018-05-07T20:36:35Z
dc.date.created2017-09-29
dc.date.issued2017-09-06none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/rehAjV9JWtOSY/PDF/264mjxoyIJJUE.pdf
dc.identifier.urihttp://edoc.rki.de/176904/2830
dc.description.abstractThe composition of the porcine virome includes viruses that infect pig cells, ancient virus-derived elements including endogenous retroviruses inserted in the pig chromosomes, and bacteriophages that infect a broad array of bacteria that inhabit pigs. Viruses infecting pigs, among them viruses also infecting human cells, as well as porcine endogenous retroviruses (PERVs) are of importance when evaluating the virus safety of xenotransplantation. Bacteriophages associated with bacteria mainly in the gut are not relevant in this context. Xenotransplantation using pig cells, tissues or organs is under development in order to alleviate the shortage of human transplants. Here for the first time published data describing the viromes in different pigs and their relevance for the virus safety of xenotransplantation is analysed. In conclusion, the analysis of the porcine virome has resulted in numerous new viruses being described, although their impact on xenotransplantation is unclear. Most importantly, viruses with known or suspected zoonotic potential were often not detected by next generation sequencing, but were revealed by more sensitive methods.eng
dc.language.isoeng
dc.publisherRobert Koch-Institut, Infektionskrankheiten / Erreger
dc.subjectHepatitis E viruseng
dc.subjectXenotransplantationeng
dc.subjectPorcine viruseseng
dc.subjectViromeeng
dc.subjectPorcine endogenous retroviruseseng
dc.subjectPorcine cytomegaloviruseng
dc.subjectPorcine circoviruseseng
dc.subject.ddc610 Medizin
dc.titleThe porcine virome and xenotransplantation
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-10055155
dc.identifier.doi10.1186/s12985-017-0836-z
dc.identifier.doihttp://dx.doi.org/10.25646/2755
local.edoc.container-titleVirology Journal
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://virologyj.biomedcentral.com/articles/10.1186/s12985-017-0836-z
local.edoc.container-publisher-nameBioMedCentral
local.edoc.container-volume14
local.edoc.container-issue171
local.edoc.container-year2017

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