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2017-10-09Zeitschriftenartikel DOI: 10.1111/1462-2920.13931
Relatedness of wildlife and livestock avian isolates of the nosocomial pathogen Acinetobacter baumannii to lineages spread in hospitals worldwide
dc.contributor.authorWilharm, Gottfried
dc.contributor.authorSkiebe, Evelyn
dc.contributor.authorHiggins, Paul G.
dc.contributor.authorPoppel, Marie T.
dc.contributor.authorBlaschke, Ulrike
dc.contributor.authorLeser, Sarah
dc.contributor.authorHeider, Christine
dc.contributor.authorHeindorf, Magdalena
dc.contributor.authorBrauner, Paul
dc.contributor.authorJäckel, Udo
dc.contributor.authorBöhland, Karin
dc.contributor.authorCuny, Christiane
dc.contributor.authorLopinska, Andzelina
dc.contributor.authorKaminski, Piotr
dc.contributor.authorKasprzak, Mariusz
dc.contributor.authorBochenski, Marcin
dc.contributor.authorCiebiera, Olaf
dc.contributor.authorTobolka, Marcin
dc.contributor.authorLayer, Franziska
dc.contributor.authorBender, Jennifer K.
dc.contributor.authorFuchs, Stephan
dc.contributor.authorSemmler, Torsten
dc.contributor.authorPfeifer, Yvonne
dc.contributor.authorJerzak, Leszek
dc.date.accessioned2018-05-07T20:42:59Z
dc.date.available2018-05-07T20:42:59Z
dc.date.created2017-10-23
dc.date.issued2017-10-09none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/rePumwJ65Qck6/PDF/29tBKCQdP9XEU.pdf
dc.identifier.urihttp://edoc.rki.de/176904/2864
dc.description.abstractThe natural habitats and potential reservoirs of the nosocomial pathogen Acinetobacter baumannii are poorly defined. Here, we put forth and tested the hypothesis of avian reservoirs of A. baumannii. We screened tracheal and rectal swab samples from livestock (chicken, geese) and wild birds (white stork nestlings) and isolated A. baumannii from 3% of sampled chicken (n = 220), 8% of geese (n = 40) and 25% of white stork nestlings (n = 661). Virulence of selected avian A. baumannii isolates was comparable to that of clinical isolates in the Galleria mellonella infection model. Whole genome sequencing revealed the close relationship of an antibiotic-susceptible chicken isolate from Germany with a multidrug-resistant human clinical isolate from China and additional linkages between livestock isolates and human clinical isolates related to international clonal lineages. Moreover, we identified stork isolates related to human clinical isolates from the United States. Multilocus sequence typing disclosed further kinship between avian and human isolates. Avian isolates do not form a distinct clade within the phylogeny of A. baumannii, instead they diverge into different lineages. Further, we provide evidence that A. baumannii is constantly present in the habitats occupied by storks. Collectively, our study suggests A. baumannii could be a zoonotic organism that may disseminate into livestock.eng
dc.language.isoeng
dc.publisherRobert Koch-Institut
dc.subject.ddc610 Medizin
dc.titleRelatedness of wildlife and livestock avian isolates of the nosocomial pathogen Acinetobacter baumannii to lineages spread in hospitals worldwide
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-10055521
dc.identifier.doi10.1111/1462-2920.13931
dc.identifier.doihttp://dx.doi.org/10.25646/2789
local.edoc.container-titleEnvironmental Microbiology
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://onlinelibrary.wiley.com/doi/10.1111/1462-2920.13931/abstract
local.edoc.container-publisher-nameWiley
local.edoc.container-volume19
local.edoc.container-issue10
local.edoc.container-year2017

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