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2017-09-23Zeitschriftenartikel DOI: 10.1016/j.ijmm.2017.09.015
Phospholipases during membrane dynamics in malaria parasites
dc.contributor.authorFlammersfeld, Ansgar
dc.contributor.authorLang, Christina
dc.contributor.authorFlieger, Antje
dc.contributor.authorPradel, Gabriele
dc.date.accessioned2018-05-07T21:06:27Z
dc.date.available2018-05-07T21:06:27Z
dc.date.created2018-02-16
dc.date.issued2017-09-23none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/reaVPouK2iI82/PDF/25fh1eAKkpmqw.pdf
dc.identifier.urihttp://edoc.rki.de/176904/2989
dc.description.abstractPlasmodium parasites, the causative agents of malaria, display a well-regulated lipid metabolism required to ensure their survival in the human host as well as in the mosquito vector. The fine-tuning of lipid metabolic pathways is particularly important for the parasites during the rapid erythrocytic infection cycles, and thus enzymes involved in lipid metabolic processes represent prime targets for malaria chemotherapeutics. While plasmodial enzymes involved in lipid synthesis and acquisition have been studied in the past, to date not much is known about the roles of phospholipases for proliferation and transmission of the malaria parasite. These phospholipid-hydrolyzing esterases are crucial for membrane dynamics during host cell infection and egress by the parasite as well as for replication and cell signaling, and thus they are considered important virulence factors. In this review, we provide a comprehensive bioinformatic analysis of plasmodial phospholipases identified to date. We further summarize previous findings on the lipid metabolism of Plasmodium, highlight the roles of phospholipases during parasite life-cycle progression, and discuss the plasmodial phospholipases as potential targets for malaria therapy.eng
dc.language.isoeng
dc.publisherRobert Koch-Institut, Infektionskrankheiten / Erreger
dc.subjectMalariaeng
dc.subjectPlasmodiumeng
dc.subjectPhospholipaseeng
dc.subjectLipid metabolismeng
dc.subjectRed blood celleng
dc.subjectMembraneeng
dc.subject.ddc610 Medizin
dc.titlePhospholipases during membrane dynamics in malaria parasites
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-10057570
dc.identifier.doi10.1016/j.ijmm.2017.09.015
dc.identifier.doihttp://dx.doi.org/10.25646/2914
local.edoc.container-titleInternational Journal of Medical Microbiology
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://www.sciencedirect.com/science/article/pii/S1438422117302849
local.edoc.container-publisher-nameElsevier
local.edoc.container-volume308
local.edoc.container-issue1
local.edoc.container-year2018

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