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2009-10-29Zeitschriftenartikel

Sociodemographic differences in return to work after stroke: the South London Stroke Register (SLSR)

Busch, Markus; Coshall, C.; Heuschmann, P. U.; McKevitt, C.; Wolfe, C. D.A.

Background: Loss of employment contributes significantly to the burden of stroke on individuals and society. There is limited information on factors influencing return to work after stroke. Objectives: To investigate the ...

2009-04-20Zeitschriftenartikel

Invasive Haemophilus influenzae infections in Germany: impact of non-type b serotypes in the post-vaccine era

Kalies, Helen; Siedler, Anette; Gröndahl, Britta; Grote, Veit; Milde-Busch, Astrid; Kries, Rüdiger von

Background: Haemophilus influenzae type b (Hib) vaccination led to a significant decrease in invasive bacterial infections in children. The aim of this study was to assess a potential shift to more non-type b invasive ...

2009-02-09Zeitschriftenartikel

Characterisation of porin genes from Mycobacterium fortuitum and their impact on growth

Sharbati, Soroush; Schramm, Kira; Rempel, Sonja; Wang, Hwa; Andrich, Ronny; Tykiel, Verena; Kunisch, Ralph; Lewin, Astrid

Background: Highly pathogenic mycobacteria like Mycobacterium tuberculosis are characterised by their slow growth and their ability to reside and multiply in the very hostile phagosomal environment and a correlation ...

2008-06-10Zeitschriftenartikel

The mycobacterial DNA-binding protein 1 (MDP1) from Mycobacterium bovis BCG influences various growth characteristics

Lewin, Astrid; Baus, Daniela; Kamal, Elisabeth; Bon, Fabienne; Kunisch, Ralph; Maurischat, Sven; Adonopoulou, Michaela; Eich, Katharina

Background: Pathogenic mycobacteria such as M. tuberculosis, M. bovis or M. leprae are characterised by their extremely slow growth rate which plays an important role in mycobacterial virulence and eradication of the ...

2007-09-07Zeitschriftenartikel

Prioritization strategies for pandemic influenza vaccine in 27 countries of the European Union and the Global Health Security Action Group: a review

Straetemans, Masja; Buchholz, Udo; Reiter, Sabine; Haas, Walter; Krause, Gérard

Background: Although there is rapid progress in vaccine research regarding influenza pandemic vaccines it is expected that pandemic influenza vaccine production can only start once the pandemic virus has been recognized. ...

2008-06-04Zeitschriftenartikel

The challenge of comprehensively mapping children's health in a nation-wide health survey: Design of the German KiGGS-Study

Kurth, Bärbel-Maria; Kamtsiuris, Panagiotis; Hölling, Heike; Schlaud, Martin; Dölle, Rüdiger; Ellert, Ute; Kahl, Heidrun; Knopf, Hildtraud; Lange, Michael; Mensink, Gert; Neuhauser, Hannelore; Rosario, Angelika Schaffrath; Scheidt-Nave, Christa; Schenk, Liane; Schlack, Robert; Stolzenberg, Heribert; Thamm, Michael; Thierfelder, Wulf; Wolf, Ute

Background: From May 2003 to May 2006, the Robert Koch Institute conducted the German Health Interview and Examination Survey for Children and Adolescents (KiGGS). Aim of this first nationwide interview and examination ...

2006-05-10Zeitschriftenartikel

Reliability of case definitions for public health surveillance assessed by Round-Robin test methodology

Krause, Gérard; Brodhun, Bonita; Altmann, Doris; Claus, Hermann; Benzler, Justus

Background: Case definitions have been recognized to be important elements of public health surveillance systems. They are to assure comparability and consistency of surveillance data and have crucial impact on the ...

2005-06-20Zeitschriftenartikel

Viral promoters can initiate expression of toxin genes introduced into Escherichia coli

Lewin, Astrid; Mayer, Martin; Chusainow, Janet; Jacob, Daniela; Appel, Bernd

Background: The expression of recombinant proteins in eukaryotic cells requires the fusion of the coding region to a promoter functional in the eukaryotic cell line. Viral promoters are very often used for this purpose. ...

2008-10-22Zeitschriftenartikel

Aetiology of community-acquired, acute gastroenteritis in hospitalised adults: a prospective cohort study

Jansen, Andreas; Stark, Klaus; Kunkel, Jan; Schreier, Eckart; Ignatius, Ralf; Liesenfeld, Oliver; Werber, Dirk; Göbel, Ulf B; Zeitz, Martin; Schneider, Thomas

Background: The aetiology of severe gastroenteritis leading to hospitalisation in adults frequently remains unclear. Our objective was to study the causes and characteristics of community-acquired, acute gastroenteritis ...

2007-09-25Zeitschriftenartikel

Relevance of the regional lymph node in scrapie pathogenesis after peripheral infection of hamsters

Kratzel, Christine; Krüger, Dominique; Beekes, Michael

Background: The exact role of the lymphoreticular system in the spread of peripheral prion infections to the central nervous system still needs further elucidation. Against this background, the influence of the regional ...

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