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2012-12-07Zeitschriftenartikel

Injektionsmilzbrand – neu aufgetretene Fälle bei Heroinabhängigen

Injection Anthrax—a New Outbreak in Heroin Users

Grunow, Roland; Verbeek, Luzie; Jacob, Daniela; Holzmann, Thomas; Birkenfeld, Gabriele; Wiens, Daniel; Eichel-Streiber, Leonie von; Grass, Gregor; Reischl, Udo

Hintergrund: Injektionsmilzbrand ist eine seltene Erkrankung bei Heroinkonsumierenden und wird durch Bacillus anthracis verursacht. Im Jahr 2012 sind vier Fälle in Deutschland aufgetreten, wovon ein Fall tödlich verlief, ...

2013-03-13Zeitschriftenartikel

Identification of a Novel Human Polyomavirus in Organs of the Gastrointestinal Tract

Korup, Sarah; Rietscher, Janita; Calvignac-Spencer, Sébastien; Trusch, Franziska; Hofmann, Jörg; Moens, Ugo; Sauer, Igor; Voigt, Sebastian; Schmuck, Rosa; Ehlers, Bernhard

Polyomaviruses are small, non-enveloped viruses with a circular double-stranded DNA genome. Using a generic polyomavirus PCR targeting the VP1 major structural protein gene, a novel polyomavirus was initially identified ...

2012-12-14Zeitschriftenartikel

Survey zur ärztlichen Verschreibung von Antibiotika: Ergebnisse zur akuten Zystitis in der ambulanten Versorgung

A Survey of Outpatient Antibiotic Prescribing for Cystitis

Velasco, Edward; Noll, Ines; Espelage, Werner; Ziegelmann, Antina; Krause, Gérard; Eckmanns, Tim

Hintergrund: Vor dem Hintergrund steigender Resistenzraten werden Einflussfaktoren auf die Verschreibung spezifischer Antibiotika bei unkomplizierter Zystitis in der ambulanten Versorgung untersucht. Methoden: Nationale ...

2013-01-24Zeitschriftenartikel

From theory to practice: molecular strain typing for the clinical and public health setting

Goering, Richard V.; Köck, Robin; Grundmann, Hajo; Werner, Guido; Friedrich, Alexander W.

The persistence and transmission of infectious disease is one of the most enduring and daunting concerns in healthcare. Over the years, epidemiological analysis especially of bacterial etiological agents has undergone a ...

2009-02-25Zeitschriftenartikel

Cross-talk between type three secretion system and metabolism in Yersinia.

Schmid, Annika; Neumayer, Wibke; Trülzsch, Konrad; Israel, Lars; Imhof, Axel; Roessle, Manfred; Sauer, Guido; Richter, Susanna; Lauw, Susan; Eylert, Eva; Eisenreich, Wolfgang; Heesemann, Jürgen; Wilharm, Gottfried

Pathogenic yersiniae utilize a type three secretion system (T3SS) to inject Yop proteins into host cells in order to undermine their immune response. YscM1 and YscM2 proteins have been reported to be functionally equivalent ...

2011-12-05Zeitschriftenartikel

Characterization of a monoclonal anti-capsid antibody that cross-reacts with three major primate lentivirus lineages

Sanders-Beer, Brigitte E.; Eschricht, Magdalena; Seifried, Janna; Hirsch, Vanessa M.; Allan, Jonathan S.; Norley, Stephen

Mouse monoclonal antibodies with varying specificities against the Gag capsid of simian and human immunodeficiency virus (SIV/HIV) were generated by immunizing mice with whole inactivated SIVagmTYO-1. Monoclonal antibody ...

2012-11-06Zeitschriftenartikel

Heterogeneity of the Stearoyl-CoA desaturase-1 (SCD1) Gene and Metabolic Risk Factors in the EPIC-Potsdam Study

Arregui, Maria; Buijsse, Brian; Stefan, Norbert; Corella, Dolores; Fisher, Eva; Giuseppe, Romina di; Coltell, Oscar; Knüppel, Sven; Aleksandrova, Krasimira; Joost, Hans-Georg; Boeing, Heiner; Weikert, Cornelia

Background: Stearoyl-CoA desaturase-1 (SCD1) is an enzyme involved in lipid metabolism. In mice and humans its activity has been associated with traits of the metabolic syndrome, but also with the prevention of saturated ...

2012-11-23Zeitschriftenartikel

Prevalence, determinants and spectrum of attention-deficit hyperactivity disorder (ADHD) medication of children and adolescents in Germany: results of the German Health Interview and Examination Survey (KiGGS)

Knopf, Hildtraud; Hölling, Heike; Huss, Michael; Schlack, Robert

Objective: To investigate the prevalence, determinants and spectrum of attention-deficit hyperactivity disorder (ADHD) medication and its associations with socioeconomic status (SES), health-related behaviour and living ...

2012-11-09Zeitschriftenartikel

Serum-free freezing media support high cell quality and excellent ELISPOT assay performance across a wide variety of different assay protocols

Filbert, Helene; Attig, Sebastian; Bidmon, Nicole; Renard, Bernhard Y.; Janetzki, Sylvia; Sahin, Ugur; Welters, Marij J. P.; Ottensmeier, Christian; Burg, Sjoerd H. van der; Gouttefangeas, Cécile; Britten, Cedrik M.

Robust and sensitive ELISPOT protocols are commonly applied concomitant with the development of new immunotherapeutics. Despite the knowledge that individual serum batches differ in their composition and may change properties ...

2012-11-06Zeitschriftenartikel

Impaired pten expression in human malignant peripheral nerve sheath tumours.

Bradtmöller, Maren; Hartmann, Christian; Zietsch, Jan; Jäschke, Sebastian; Mautner, Victor-F.; Kurtz, Andreas; Park, Su-Jin; Baier, Michael; Harder, Anja; Reuss, David; Deimling, Andreas von; Heppner, Frank L.; Holtkamp, Nikola

Malignant peripheral nerve sheath tumours (MPNST) are aggressive sarcomas that develop in about 10% of patients with the genetic disease neurofibromatosis type 1 (NF1). Molecular alterations contributing to MPNST formation ...

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