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2013-06-20Zeitschriftenartikel

Novel Polyomaviruses of Nonhuman Primates: Genetic and Serological Predictors for the Existence of Multiple Unknown Polyomaviruses within the Human Population

Scuda, Nelly; Madinda, Nadege Freda; Akoua-Koffi, Chantal; Adjogoua, Edgard Valerie; Wevers, Diana; Hofmann, Jörg; Cameron, Kenneth N.; Leendertz, Siv Aina J.; Couacy-Hymann, Emmanuel; Robbins, Martha; Boesch, Christophe; Jarvis, Michael A.; Moens, Ugo; Mugisha, Lawrence; Calvignac-Spencer, Sébastien; Leendertz, Fabian; Ehlers, Bernhard

Polyomaviruses are a family of small non-enveloped DNA viruses that encode oncogenes and have been associated, to greater or lesser extent, with human disease and cancer. Currently, twelve polyomaviruses are known to ...

2013-04-04Zeitschriftenartikel

Indirect Immunofluorescence Assay for the Simultaneous Detection of Antibodies against Clinically Important Old and New World Hantaviruses

Lederer, Sabine; Lattwein, Erik; Hanke, Merle; Sonnenberg, Karen; Stoecker, Winfried; Lundkvist, Åke; Vaheri, Antti; Vapalahti, Olli; Chan, Paul K. S.; Feldmann, Heinz; Dick, Daryl; Schmidt-Chanasit, Jonas; Padula, Paula; Vial, Pablo A.; Panculescu-Gatej, Raluca; Ceianu, Cornelia; Heyman, Paul; Avšič-Županc, Tatjana; Niedrig, Matthias

In order to detect serum antibodies against clinically important Old and New World hantaviruses simultaneously, multiparametric indirect immunofluorescence assays (IFAs) based on biochip mosaics were developed. Each of the ...

2013-06-21Zeitschriftenartikel

The Attenuated Brucella abortus Strain 19 Invades, Persists in, and Activates Human Dendritic Cells, and Induces the Secretion of IL-12p70 but Not IL-23

Weinhold, Mario; Eisenblätter, Martin; Jasny, Edith; Fehlings, Michael; Finke, Antje; Gayum, Hermine; Rüschendorf, Ursula; Viveros, Pablo Renner; Moos, Verena; Allers, Kristina; Schneider, Thomas; Schaible, Ulrich E.; Schumann, Ralf R.; Mielke, Martin; Ignatius, Ralf

Background: Bacterial vectors have been proposed as novel vaccine strategies to induce strong cellular immunity. Attenuated strains of Brucella abortus comprise promising vector candidates since they have the potential ...

2012-07-23Zeitschriftenartikel

Influenzaimpfquoten in hessischen Krankenhäusern

Wicker, Sabine; Gottschalk, René; Wolff, U.; Krause, Gérard; Rabenau, Holger F.

Influenzainfektionen können sich in Krankenhäusern schnell ausbreiten, nosokomiale Influenzaübertragungen sind wiederholt beschrieben worden. Die Influenzaimpfung des medizinischen Personals ist eine wichtige Maßnahme, um ...

2013-06-12Zeitschriftenartikel

Antibody Responses in Humans Infected with Newly Emerging Strains of West Nile Virus in Europe

Chabierski, Stefan; Makert, Gustavo R.; Kerzhner, Alexandra; Barzon, Luisa; Fiebig, Petra; Liebert, Uwe G.; Papa, Anna; Richner, Justin M.; Niedrig, Matthias; Diamond, Michael S.; Palu, Giorgio; Ulbert, Sebastian

Infection with West Nile Virus (WNV) affects an increasing number of countries worldwide. Although most human infections result in no or mild flu-like symptoms, the elderly and those with a weakened immune system are at ...

2013-06-01Zeitschriftenartikel

Novel Mycobacterium tuberculosis Complex Isolate from a Wild Chimpanzee

Coscolla, Mireia; Lewin, Astrid; Metzger, Sonja; Mätz-Rennsing, Kerstin; Calvignac-Spencer, Sébastien; Nitsche, Andreas; Dabrowski, Piotr Wojtek; Radonić, Aleksandar; Niemann, Stefan; Parkhill, Julian; Couacy-Hymann, Emmanuel; Feldman, Julia; Comas, Iñaki; Boesch, Christophe; Gagneux, Sebastien; Leendertz, Fabian

Tuberculosis (TB) is caused by gram-positive bacteria known as the Mycobacterium tuberculosis complex (MTBC). MTBC include several human-associated lineages and several variants adapted to domestic and, more rarely, wild ...

2013-05-23Zeitschriftenartikel

International External Quality Assessment of Molecular Detection of Rift Valley Fever Virus

Escadafal, Camille; Paweska, Janusz T.; Grobbelaar, Antoinette; Roux, Chantel le; Bouloy, Michèle; Patel, Pranav; Teichmann, Anette; Mantke, Oliver Donoso; Niedrig, Matthias

Rift Valley fever (RVF) is a viral zoonosis that primarily affects animals resulting in considerable economic losses due to death and abortions among infected livestock. RVF also affects humans with clinical symptoms ranging ...

2013-06-01Zeitschriftenartikel

BSE-associated Prion-Amyloid Cardiomyopathy in Primates

Krasemann, Susanne; Mearini, Giulia; Krämer, Elisabeth; Wagenführ, Katja; Schulz-Schaeffer, Walter; Neumann, Melanie; Bodemer, Walter; Kaup, Franz-Josef; Beekes, Michael; Carrier, Lucie; Aguzzi, Adriano; Glatzel, Markus

Prion amyloidosis occurred in the heart of 1 of 3 macaques intraperitoneally inoculated with bovine spongiform encephalopathy prions. This macaque had a remarkably long duration of disease and signs of cardiac distress. ...

2012-07-23Zeitschriftenartikel

Blut – aber sicher!

Offergeld, Ruth

2012-11-14Zeitschriftenartikel

Desinfektion von Persönlicher Schutzausrüstung

Methodenentwicklung zur standardisierten Untersuchung der Wirksamkeit von Desinfektionsmitteln auf Oberflächen der Persönlichen Schutzausrüstunggegen Sporen, Viren und Toxine unter praxisnahen Bedingungenund Anwendung der Untersuchungsmethoden am Beispiel von Peressigsäure

Lemmer, Karin; Roder, Anja; Nattermann, Herbert; Schwebke, Ingeborg; Mielke, Martin; Dorner, Brigitte; Pauli, Georg; Grunow, Roland

Die Dekontamination von Persönlicher Schutzausrüstung (PSA) in biologischer Gefahrenlage mit Verdacht auf Kontamination der PSA durch ein hochpathogenes biologisches Agens sollte effektiv, in kurzer Zeit durchführbar ...

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