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2011-05-27Zeitschriftenartikel

Quantitative detection and biological propagation of scrapie seeding activity in vitro facilitate use of prions as model pathogens for disinfection.

Pritzkow, Sandra; Wagenführ, Katja; Daus, Martin L.; Boerner, Susann; Lemmer, Karin; Thomzig, Achim; Mielke, Martin; Beekes, Michael

Prions are pathogens with an unusually high tolerance to inactivation and constitute a complex challenge to the re-processing of surgical instruments. On the other hand, however, they provide an informative paradigm which ...

2011-05-09Zeitschriftenartikel

Identification of the protease cleavage sites in a reconstituted Gag polyprotein of an HERV-K(HML-2) element

George, Maja; Schwecke, Torsten; Beimforde, Nadine; Hohn, Oliver; Chudak, Claudia; Zimmermann, Anja; Kurth, Reinhard; Naumann, Dieter; Bannert, Norbert

Background: The human genome harbors several largely preserved HERV-K(HML-2) elements. Although this retroviral family comes closest of all known HERVs to producing replication competent virions, mutations acquired during ...

2011-05-05Zeitschriftenartikel

Antibiotic resistance and molecular epidemiology of Staphylococcus aureus in Nigeria

Shittu, Adebayo; Okon, Kenneth; Adesida, Solayide; Oyedara, Omotayo; Witte, Wolfgang; Strommenger, Birgit; Layer, Franziska; Nübel, Ulrich

Background: Staphylococcus aureus is an important pathogen causing a wide range of infections in the hospital and community setting. In order to have adequate information for treatment of S. aureus infections, it is crucial ...

2011-05-31Zeitschriftenartikel

Emergence and Persistence of Minor Drug-Resistant HIV-1 Variants in Ugandan Women after Nevirapine Single-Dose Prophylaxis.

Hauser, Andrea; Mugenyi, Kizito; Kabasinguzi, Rose; Kücherer, Claudia; Harms, Gundel; Kunz, Andrea

Background: Nevirapine (NVP) single-dose is still a widely used antiretroviral prophylaxis for the prevention of vertical HIV-1 transmission in resource-limited settings. However, the main disadvantage of the Non-nucleoside ...

2011-06-16Zeitschriftenartikel

Enhanced surveillance during a large outbreak of bloody diarrhoea and haemolytic uraemic syndrome caused by Shiga toxin/verotoxin-producing Escherichia coli in Germany, May to June 2011

Wadl, Maria; Rieck, Thorsten; Nachtnebel, Matthias; Greutélaers, Benedikt; Heiden, Matthias an der; Altmann, Doris; Hellenbrand, Wiebke; Faber, Mirko; Frank, Christina; Schweickert, Birgitta; Krause, Gérard; Benzler, Justus; Eckmanns, Tim

Germany has a well established broad statutory surveillance system for infectious diseases. In the context of the current outbreak of bloody diarrhoea and haemolytic uraemic syndrome caused by Shiga toxin/verotoxin-producing ...

2011-05-26Zeitschriftenartikel

Large and ongoing outbreak of haemolytic uraemic syndrome, Germany, May 2011

Frank, Christina; Faber, Mirko; Askar, Mona; Bernard, Helen; Fruth, Angelika; Gilsdorf, Andreas; Höhle, Michael; Karch, Helge; Krause, Gérard; Prager, Rita; Spode, Anke; Stark, Klaus; Werber, Dirk

Since early May 2011, an increased incidence of haemolytic uraemic syndrome (HUS) and bloody diarrhoea related to infections with Shiga toxin-producing Escherichia coli (STEC) has been observed in Germany, with most cases ...

2011-05-12Zeitschriftenartikel

An outbreak of Salmonella Typhimurium traced back to salami, Denmark, April to June 2010

Kuhn, K. G.; Torpdahl, M.; Frank, Christina; Sigsgaard, K.; Ethelberg, Steen

Between April and June 2010, a small national outbreak of Salmonella Typhimurium with a particular multilocus variable-number tandem repeat analysis (MLVA) type was identified in Denmark through laboratory-based surveillance. ...

2011-06-02Zeitschriftenartikel

Update on the ongoing outbreak of haemolytic uraemic syndrome due to Shiga toxin-producing Escherichia coli (STEC) serotype O104, Germany, May 2011

Askar, Mona; Faber, Mirko; Frank, Christina; Bernard, Helen; Gilsdorf, Andreas; Fruth, Angelika; Prager, Rita; Höhle, Michael; Süß, Thorsten; Wadl, Maria; Krause, Gérard; Stark, Klaus; Werber, Dirk

Since early May 2011, a large outbreak of haemolytic uraemic syndrome (HUS) and bloody diarrhoea related to infections with Shiga toxin-producing Escherichia coli (STEC) has been observed in Germany. The outbreak is focused ...

2011-05-02Zeitschriftenartikel

Klimawandel und Gesundheit - ein Sachstandsbericht

Eis, Dieter; Helm, Dieter; Laußmann, Detlef; Stark, Klaus

2011-06-17Zeitschriftenartikel

The IFN-γ-Inducible GTPase, Irga6, Protects Mice against Toxoplasma gondii but Not against Plasmodium berghei and Some Other Intracellular Pathogens.

Liesenfeld, Oliver; Parvanova, Iana; Zerrahn, Jens; Han, Seong-Ji; Muñoz, Melba; Kaiser, Frank; Aebischer, Toni; Buch, Thorsten; Waisman, Ari; Reichmann, Gaby; Utermöhlen, Olaf; Stebut, Esther von; Loewenich, Friederike D. von; Bogdan, Christian; Specht, Sabine; Saeftel, Michael; Hoerauf, Achim; Mota, Maria M.; Könen-Waisman, Stephanie; Kaufmann, Stefan H. E.; Howard, Jonathan C.

Clearance of infection with intracellular pathogens in mice involves interferon-regulated GTPases of the IRG protein family. Experiments with mice genetically deficient in members of this family such as Irgm1(LRG-47), ...

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