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2012-09-01Zeitschriftenartikel

Effectiveness and Timing of Vaccination during School Measles Outbreak

Marinović, Axel Antonio Bonačić; Swaan, Corien; Wichmann, Ole; Steenbergen, Jim van; Kretzschmar, Mirjam

Despite high vaccination coverage in most European countries, large community outbreaks of measles do occur, normally clustered around schools and resulting from suboptimal vaccination coverage. To determine whether or ...

2011-02-10Zeitschriftenartikel

Immunological properties of the transmembrane envelope protein of the feline foamy virus and its use for serological screening

Mühle, Michael; Bleiholder, Anne; Kolb, Susanne; Hübner, Janine; Löchelt, Martin; Denner, Joachim

The transmembrane envelope (TM) proteins of retroviruses are used as antigen in diagnostic immunoassays and they represent a conserved target for neutralizing antibodies. To analyze the situation in infections with the ...

2011-09-24Zeitschriftenartikel

Optimisation of expression and purification of the feline and primate foamy virus transmembrane envelope proteins using a 96 deep well screen

Mühle, Michael; Löchelt, Martin; Denner, Joachim

The production of recombinant transmembrane proteins is due to their biochemical properties often troublesome and time consuming. Here the prokaryotic expression and purification of the transmembrane envelope proteins of ...

2010-12-02Zeitschriftenartikel

Resistente Tuberkulose

Zunehmende Probleme und Lösungsansätze

Hauer, Barbara; Castell, S.; Loddenkemper, Robert

Die Medikamentenresistenz stellt bei der Tuberkulose (TB) ein zunehmendes Problem dar. Eine multiresistente (MDR-)TB wird bereits bei 440.000 Fällen, eine extensiv resistente (XDR-)TB bei 25.000 Fällen der weltweit über 9 ...

2012-09-01Zeitschriftenartikel

EHEC O104:H4 in Germany 2011: Large outbreak of bloody diarrhea and haemolytic uraemic syndrome by shiga toxin-producing E. coli via contaminated food

Burger, Reinhard

In the summer of 2011 Germany experienced one of the largest outbreaks of a food-borne infection caused by enterohaemorrhagic Escherichia coli (EHEC) with the serotype O104:H4. A large number of cases with bloody diarrhea ...

2012-05-04Zeitschriftenartikel

Assessment of the human medical significance of the rabies zoonosis in Germany – analysis of available data and desiderata

Abschätzung der humanmedizinischen Bedeutung der Zoonose Tollwut in Deutschland – Analyse der verfügbaren Daten und Desiderate

Ross, R. Stefan; Freuling, Conrad M.; Deleré, Yvonne; Müller, Thomas

Um die humanmedizinische Bedeutung der Zoonose Tollwut in Deutschland abzuschätzen, wurden für die Jahre 2006–2010 Daten der einschlägigen „Surveillance“ und des Meldewesens sowie die in der gesetzlichen Krankenversicherung ...

2012-10-01Zeitschriftenartikel

Autochthonous and Dormant Cryptococcus gattii Infections in Europe

Hagen, Ferry; Colom, M. Francisca; Swinne, Daniëlle; Tintelnot, Kathrin; Iatta, Roberta; Montagna, Maria Teresa; Torres-Rodriguez, Josep M.; Cogliati, Massimo; Velegraki, Aristea; Burggraaf, Arjan; Kamermans, Alwin; Sweere, Johanna M.; Meis, Jacques F.; Klaassen, Corné H.W.; Boekhout, Teun

Until recently, Cryptococcus gattii infections occurred mainly in tropical and subtropical climate zones. However, during the past decade, C. gattii infections in humans and animals in Europe have increased. To determine ...

2010-05-31Zeitschriftenartikel

Langfristig wirksame Zweit-Therapie der HIV-Infektion bei Klassenwechsel nach virologischem Versagen unter Protease-Inhibitoren

Long-term efficacy of second-line treatment of HIV infection after class change following virological failure on protease inhibitor-based therapy

Brunner, J.; Seybold, U.; Gunsenheimer-Bartmeyer, Barbara; Hamouda, Osamah; Bogner, Johannes

Hintergrund: Während für die Initialtherapie der HIV-Infektion evidenzbasierte Empfehlungen für die Auswahl der antiretroviralen Kombinationstherapie (cART) bestehen, existieren zur Zweit-Therapie nach erstem virologischem ...

2007-12-01Zeitschriftenartikel

Prion propagation in a nerve conduit model containing segments devoid of axons

Kratzel, Christine; Krüger, Dominique; Beekes, Michael

Prions, the putative causative agents of transmissible spongiform encephalopathies, are neurotropic pathogens that spread to the central nervous system via synaptically linked neural conduits upon peripheral infection. ...

2011-09-15Zeitschriftenartikel

Emergence of bla CTX-M-15, qnrB1 and aac(6′)-ib-cr resistance genes in Pantoea agglomerans and enterobacter cloacae from Nigeria (sub-Saharan Africa)

Aibinu, Ibukun; Pfeifer, Yvonne; Peters, Folake; Ogunsola, Folasade; Adenipekun, Eyitayo; Odugbemi, Tolu; König, Wolfgang

Besides hyper-production of chromosomal AmpC β-lactamases, the expression of plasmid-encoded extended-spectrum β-lactamases (ESBL) in Enterobacter spp has increased in recent years. In this study, we characterized 10 ...

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