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2018-07-30Zeitschriftenartikel
Intracellular membranes of bacterial endospores are reservoirs for spore core membrane expansion during spore germination 
Laue, Michael; Han, Hong-Mei; Dittmann, Christin; Setlow, Peter
Bacterial endospores are formed by certain bacteria, such as Bacillus subtilis or the pathogenic Bacillus anthracis and Clostridioides difficile, to allow survival in environmental conditions which are lethal to vegetative ...
2018-08-06Zeitschriftenartikel
The usefulness of C-reactive protein in predicting malaria parasitemia in a sub-Saharan African region 
Sarfo, Bismark Osei; Hahn, Andreas; Schwarz, Norbert Georg; Jaeger, Anna; Sarpong, Nimako; Marks, Florian; Adu-Sarkodie, Yaw; Tamminga, Thalea; May, Juergen
Background: Malaria remains a leading cause of childhood mortality in sub-Saharan Africa. Identifying patients who are at risk for severe manifestations at presentation still remains challenging. This study examines ...
2018-03-17Zeitschriftenartikel
Screening of migrants for tuberculosis identifies patients with multidrug-resistant tuberculosis but is not sufficient 
Helbling, P.; Kröger, Stefan; Haas, Walter; Brusin, S.; Cirillo, D. M.; Groenheit, R.; Guthmann, J. P.; Soini, Hanna; Hendrickx, D.; van der Werf, M. J.
2018-05-02Zeitschriftenartikel
A lipid-binding loop of botulinum neurotoxin serotypes B, DC and G is an essential feature to confer their exquisite potency 
Stern, Daniel; Weisemann, Jasmin; Le Blanc, Alexander; von Berg, Laura; Mahrhold, Stefan; Piesker, Janett; Laue, Michael; Luppa, Peter B.; Dorner, Martin B.; Dorner, Brigitte G.; Rummel, Andreas
The exceptional toxicity of botulinum neurotoxins (BoNTs) is mediated by high avidity binding to complex polysialogangliosides and intraluminal segments of synaptic vesicle proteins embedded in the presynaptic membrane. ...
2018-05-09Zeitschriftenartikel
Is there a duty to participate in digital epidemiology? 
Mittelstadt, Brent; Benzler, Justus; Engelmann, Lukas; Prainsack, Barbara; Vayena, Effy
This paper poses the question of whether people have a duty to participate in digital epidemiology. While an implied duty to participate has been argued for in relation to biomedical research in general, digital epidemiology ...
2018-07-10Zeitschriftenartikel
Do adolescents understand the items of the European Health Literacy Survey Questionnaire (HLS-EU-Q47) – German version? Findings from cognitive interviews of the project “Measurement of Health Literacy Among Adolescents” (MOHLAA) in Germany 
Domanska, Olga; Firnges, Christiane; Bollweg, Torsten Michael; Sørensen, Kristine; Holmberg, Christine; Jordan, Susanne
Background: In Germany, there are no measurement tools to assess the general health literacy of adolescents. The aim of the study “Measurement of Health Literacy Among Adolescents” (MOHLAA) is to develop such a tool for ...
2017-11-24Zeitschriftenartikel
AureoWiki ̵ The repository of the Staphylococcus aureus research and annotation community 
Fuchs, Stephan; Mehlan, Henry; Bernhardt, Jörg; Hennig, André; Michalik, Stephan; Surmann, Kristin; Pané-Farré, Jan; Giese, Anne; Weiss, Stefan; Backert, Linus; Herbig, Alexander; Nieselt, Kay; Hecker, Michael; Völker, Uwe; Mäder, Ulrike
In light of continuously accumulating data and knowledge on major human pathogens, comprehensive and up-to-date sources of easily accessible information are urgently required. The AureoWiki database (http://aureowiki.med ...
2018-05-02Zeitschriftenartikel
Genome-based analysis of Carbapenemase-producing Klebsiella pneumoniae isolates from German hospital patients, 2008-2014 
Becker, Laura; Kaase, Martin; Pfeifer, Yvonne; Fuchs, Stephan; Reuss, Annicka; von Laer, Anja; Abu Sin, Muna; Korte-Berwanger, Miriam; Gatermann, Sören; Werner, Guido
Background By using whole genome sequence data we aimed at describing a population snapshot of carbapenemase-producing K. pneumoniae isolated from hospitalized patients in Germany between 2008 and 2014. Methods We ...
2018-07-12Zeitschriftenartikel
Absence of IL-10 production by human PBMCs co-cultivated with human cells expressing or secreting retroviral immunosuppressive domains 
Ivanusic, Daniel; Pietsch, Heiko; König, Jasper; Denner, Joachim
Immunosuppression by retroviruses including the human immunodeficiency virus—1 (HIV-1) is well known, however the mechanisms how retroviruses induce this immunosuppression is not fully investigated. It was shown that ...
2018-06-05Zeitschriftenartikel
Carbapenem non-susceptibility of Klebsiella pneumoniae isolates in hospitals from 2011 to 2016, data from the German Antimicrobial Resistance Surveillance (ARS) 
Koppe, Uwe; von Laer, Anja; Kroll, Lars E.; Noll, Ines; Feig, Marcel; Schneider, Marc; Claus, Hermann; Eckmanns, Tim; Abu Sin, Muna
Background: Carbapenem resistance in Klebsiella pneumoniae is of significant public health concern and recently spread across several countries. We investigated the extent of carbapenem non-susceptibility in K. pneumoniae ...
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