XCL1 is the ligand for XCR1, a chemokine receptor uniquely expressed on crosspresenting dendritic cells (DC) in mouse and man. We are interested in establishing therapeutic vaccines based on XCL1-mediated targeting of ...

Hepatitis E virus genotype 1 (HEV-1) is associated with large epidemics. Notably, HEV subtype 1e (HEV-1e) has caused HEV outbreaks in sub-Saharan Africa. We report here the second full-length genome sequence of an HEV-1e ...

Hintergrund Bereits im Kindes- und Jugendalter sind gesundheitliche Ungleichheiten zuungunsten sozial benachteiligter Bevölkerungsgruppen festzustellen. Der Beitrag untersucht, inwiefern sich Unterschiede in der subjektiven ...

Introduction The HIV epidemic represents an important public health issue in Europe particularly among men who have sex with men (MSM). Global AIDS Monitoring indicators (GAM) have been widely and jointly promoted as a ...

Paratuberculosis is a major disease in cattle that severely affects animal welfare and causes huge economic losses worldwide. Development of alternative diagnostic methods is of urgent need to control the disease. Recent ...

Virus ecology and evolution play a central role in disease emergence. However, their relative roles will vary depending on the viruses and ecosystems involved. We combined field studies, phylogenetics and experimental ...

Hintergrund Im September 2014 beauftragte die Bundesregierung das Deutsche Rote Kreuz (DRK) und die Bundeswehr, die Eindämmung der Ebolafieberepidemie in Westafrika zu unterstützen. Das DRK fragte Ausbildung für Einsatzkräfte ...

Demografische Alterung und Rückgang oder Schrumpfung der Bevölkerungszahl in vielen Gebieten der Bundesrepublik Deutschland sind Kernelemente des demografischen Wandels. Für die betroffenen Regionen ergibt sich eine sinkende ...

There are a huge number of pathogens with multi-component transmission cycles, involving amplifier hosts, vectors or complex pathogen life cycles. These complex systems present challenges in terms of modeling and policy ...

Background Pre-exposure prophylaxis (PrEP) is a highly effective HIV prevention strategy for men-who-have-sex-with-men (MSM). The high cost of PrEP has until recently been a primary barrier to its use. In 2017, generic ...