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2018-07-12Zeitschriftenartikel
Need for additional capacity and improved capability for molecular detection of yellow fever virus in European Expert Laboratories: External Quality Assessment, March 2018 
Domingo, Cristina; Ellerbrok, Heinz; Koopmans, Marion; Nitsche, Andreas; Leitmeyer, Katrin; Charrel, Rémi N.; Reusken, Chantal B.
An external quality assessment of yellow fever virus (YFV) molecular detection in European laboratories was organised in rapid response to an increase in human cases in Brazil in 2018 with risk of import to Europe. Detection ...
2018-07-05Zeitschriftenartikel
Two concurrent outbreaks of hepatitis A highlight the risk of infection for non-immune travellers to Morocco, January to June 2018 
Gassowski, Martyna; Michaelis, Kai; Wenzel, Jürgen J.; Faber, Mirko; Figoni, Julie; Mouna, Lina; Friesema, Ingrid H. M.; Vennema, Harry; Avellon, Ana; Varela, Carmen; Sundqvist, Lena; Lundberg Ederth, Josefine; Plunkett, James; Balogun, Koye; Ngui, Siew Lin; Midgley, Sofie Elisabeth; Gillesberg Lassen, Sofie; Müller, Luise
From January to June 2018, two ongoing hepatitis A outbreaks affected travellers returning from Morocco and cases in Europe without travel history, resulting in 163 patients in eight European countries. Most interviewed ...
2018-11-02Zeitschriftenartikel
Update on prevalence and mechanisms of resistance to linezolid, tigecycline and daptomycin in enterococci in Europe: Towards a common nomenclature 
Bender, Jennifer K.; Cattoir, Vincent; Hegstad, Kristin; Sadowy, Ewa; Coque, Teresa M.; Westh, Henrik; Hammerum, Anette M.; Schaffer, Kirsten; Burns, Karen; Murchan, Stephen; Novais, Carla; Freitas, Ana R.; Peixe, Luísa; Del Grosso, Maria; Pantosti, Annalisa; Werner, Guido
Vancomycin-resistant enterococci (VRE) are important nosocomial pathogens. Invasive VRE infections are difficult to treat since common therapeutic options including ampicillin and glycopeptides often fail. In vitro, most ...
2019-03-08Zeitschriftenartikel
Global monitoring of antimicrobial resistance based on metagenomics analyses of urban sewage 
Hendriksen, Rene S.; Munk, Patrick; Njage, Patrick; van Bunnik, Bram; McNally, Luke; Lukjancenko, Oksana; Röder, Timo; Nieuwenhuijse, David; Karlsmose Pedersen, Susanne; Kjeldgaard, Jette; Kaas, Rolf S.; Lanken Conradsen Clausen, Philip Thomas; Vogt, Josef Korbinian; Leekitcharoenphon, Pimlapas; van de Schans, Milou G. M.; Zuidema, Tina; de Roda Husman, Ana Maria; Rasmussen, Simon; Petersen, Bent; The Global Sewage Surveillance project consortium; Amid, Clara; Cochrane, Guy; Sicheritz-Ponten, Thomas; Schmitt, Heike; Alvarez, Jorge Raul Matheu; Aidara-Kane, Awa; Pamp, Sünje J.; Lund, Ole; Hald, Tine; Woolhouse, Mark; Koopmans, Marion P.; Vigre, Håkan; Nordahl Petersen, Thomas; Aarestrup, Frank M.
Antimicrobial resistance (AMR) is a serious threat to global public health, but obtaining representative data on AMR for healthy human populations is difficult. Here, we use metagenomic analysis of untreated sewage to ...
2018-02-02Zeitschriftenartikel
Mendelian adult-onset leukodystrophy genes in Alzheimer's disease: critical influence of CSF1R and NOTCH3 
Sassi, Celeste; Nalls, Michael A.; Ridge, Perry G.; Gibbs, Jesse R.; Lupton, Michelle K.; Troakes, Claire; Lunnon, Katie; Al-Sarraj, Safa; Brown, Kristelle S.; Medway, Christopher; Lord, Jenny; Turton, James; Bras, Jose; Passmore, Peter; Craig, David; Johnston, Janet; McGuinness, Bernadette; Todd, Stephen; Heun, Reinhard; Kölsch, Heike; Kehoe, Patrick G.; Vardy, Emma R. L. C.; Hooper, Nigel M.; Smith, A. David; Wilcock, Gordon; Warden, Donald; Holmes, Clive; Blumenau, Sonja; Thielke, Mareike; Josties, Christa; Freyer, Dorette; Dietrich, Annette; Hammer, Monia; Baier, Michael; Dirnagl, Ulrich; Morgan, Kevin; Powell, John F.; Kauwe, John S.; Cruchaga, Carlos; Goate, Alison M.; Singleton, Andrew B.; Guerreiro, Rita; Hodges, Angela; Hardy, John
Mendelian adult-onset leukodystrophies are a spectrum of rare inherited progressive neurodegenerative disorders affecting the white matter of the central nervous system. Among these, cerebral autosomal dominant and recessive ...
2018-10-22Zeitschriftenartikel
Bringing together what belongs together: Optimizing murine infection models by using mouse-adapted Staphylococcus aureus strains 
Trübe, Patricia; Hertlein, Tobias; Mrochen, Daniel M.; Schulz, Daniel; Jorde, Ilka; Krause, Bettina; Zeun, Julia; Fischer, Stefan; Wolf, Silver A.; Walther, Birgit; Semmler, Torsten; Bröker, Barbara M.; Ulrich, Rainer G.; Ohlsen, Knut; Holtfreter, Silva
Staphylococcus (S.) aureus is a leading cause of bacterial infection world-wide, and currently no vaccine is available for humans. Vaccine development relies heavily on clinically relevant infection models. However, the ...
2018-07-12Zeitschriftenartikel
Yellow fever in the diagnostics laboratory 
Domingo, Christina; Charrel, Rémi N.; Schmidt-Chanasit, Jonas; Zeller, Hervé; Reusken, Chantal
Yellow fever (YF) remains a public health issue in endemic areas despite the availability of a safe and effective vaccine. In 2015–2016, urban outbreaks of YF were declared in Angola and the Democratic Republic of Congo, ...
2019-02-26Zeitschriftenartikel
Intergenerational Educational Pathways and Self-Rated Health in Adolescence and Young Adulthood: Results of the German KiGGS Cohort 
Waldhauer, Julia; Kuntz, Benjamin; Mauz, Elvira; Lampert, Thomas
Health differences in social mobility are often analysed by income differences or different occupational positions. However, in early adulthood many young people still have very diffuse income situations and are not always ...
2018-07-29Zeitschriftenartikel
The European Virus Archive goes global: A growing resource for research 
Romette, J. L.; Prat, C. M.; Gould, E. A.; de Lamballerie, X.; Charrel, R.; Coutard, B.; Fooks, A. R.; Bardsley, M.; Carroll, M.; Drosten, C.; Drexler, J.F.; Günther, S.; Klempa, B.; Pinschewer, D.; Klimkait, T.; Avsic-Zupanc, T.; Capobianchi, M. R.; Dicaro, A.; Ippolito, G.; Nitsche, A.; Koopmans, M.; Reusken, C.; Gorbalenya, A.; Raoul, H.; Bourhy, H.; Mettenleiter, T.; Reiche, S.; Batten, C.; Sabeta, C.; Paweska, J. T.; Eropkin, M.; Zverev, V.; Hu, Z.; Mac Cullough, S.; Mirazimi, A.; Pradel, F.; Lieutaud, P.
The European Virus Archive (EVA) was created in 2008 with funding from the FP7-EU Infrastructure Programme, in response to the need for a coordinated and readily accessible collection of viruses that could be made available ...
2018-07-19Zeitschriftenartikel
A novel European H5N8 influenza A virus has increased virulence in ducks but low zoonotic potential 
Grund, Christian; Hoffmann, Donata; Ulrich, Reiner; Naguib, Mahmoud; Schinköthe, Jan; Hoffmann, Bernd; Harder, Timm; Saenger, Sandra; Zscheppang, Katja; Tönnies, Mario; Hippenstiel, Stefan; Hocke, Andreas; Wolff, Thorsten; Beer, Martin
We investigated in a unique setup of animal models and a human lung explant culture biological properties, including zoonotic potential, of a representative 2016 highly pathogenic avian influenza virus (HPAIV) H5N8, clade ...
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