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2021-11-21Zeitschriftenartikel

Re-emergence of enterovirus D68 in Europe after easing the COVID-19 lockdown, September 2021

Benschop, Kimberley SM; Albert, Jan; Anton, Andres; Andrés, Cristina; Aranzamendi, Maitane; Armannsdóttir, Brynja; Bailly, Jean-Luc; Baldanti, Fausto; Baldvinsdóttir, Guðrún Erna; Beard, Stuart; Berginc, Natasa; Böttcher, Sindy; Blomqvist, Soile; Bubba, Laura; Calvo, Cristina; Cabrerizo, Maria; Cavallero, Annalisa; Celma, Cristina; Ceriotti, Ferruccio; Costa, Inês; Cottrell, Simon; Cuerpo, Margarita del; Dean, Jonathan; Dembinski, Jennifer L; Diedrich, Sabine; Diez-Domingo, Javier; Dorenberg, Dagny Haug; Duizer, Erwin; Dyrdak, Robert; Fanti, Diana; Farkas, Agnes; Feeney, Susan; Flipse, Jacky; Gascun, Cillian De; Galli, Cristina; Georgieva, Irina; Gifford, Laura; Guiomar, Raquel; Hönemann, Mario; Ikonen, Niina; Jeannoël, Marion; Josset, Laurence; Keeren, Kathrin; López-Labrador, F Xavier; Maier, Melanie; McKenna, James; Meijer, Adam; Mengual-Chuliá, Beatriz; Midgley, Sofie E; Mirand, Audrey; Montes, Milagrosa; Moore, Catherine; Morley, Ursula; Murk, Jean-Luc; Nikolaeva-Glomb, Lubomira; Numanovic, Sanela; Oggioni, Massimo; Palminha, Paula; Pariani, Elena; Pellegrinelli, Laura; Piralla, Antonio; Pietsch, Corinna; Piñeiro, Luis; Rabella, Núria; Rainetova, Petra; Uceda Renteria, Sara Colonia; Romero, María P; Reynders, Marijke; Roorda, Lieuwe; Savolainen-Kopra, Carita; Schuffenecker, Isabelle; Soynova, Aysa; Swanink, Caroline MA; Ursic, Tina; Verweij, Jaco J; Vila, Jorgina; Vuorinen, Tytti; Simmonds, Peter; Fischer, Thea K; Harvala, Heli

We report a rapid increase in enterovirus D68 (EV-D68) infections, with 139 cases reported from eight European countries between 31 July and 14 October 2021. This upsurge is in line with the seasonality of EV-D68 and was ...

2021-10-14Zeitschriftenartikel

Heatwave-associated Vibrio infections in Germany, 2018 and 2019

Brehm, Thomas Theo; Berneking, Laura; Martins, Meike Sena; Dupke, Susann; Jacob, Daniela; Drechsel, Oliver; Bohnert, Jürgen; Becker, Karsten; Kramer, Axel; Christner, Martin; Aepfelbacher, Martin; Schmiedel, Stefan; Rohde, Holger; the German Vibrio Study Group

Background: Vibrio spp. are aquatic bacteria that prefer warm seawater with moderate salinity. In humans, they can cause gastroenteritis, wound infections, and ear infections. During the summers of 2018 and 2019, unprecedented ...

2021-11-11Zeitschriftenartikel

Viral Myocarditis—From Pathophysiology to Treatment

Schultheiss, Heinz-Peter; Baumeier, Christian; Aleshcheva, Ganna; Bock, Claus-Thomas; Escher, Felicitas

The diagnosis of acute and chronic myocarditis remains a challenge for clinicians. Characterization of this disease has been hampered by its diverse etiologies and heterogeneous clinical presentations. Most cases of ...

2021-11-02Zeitschriftenartikel

Machine Learning for Health: Algorithm Auditing & Quality Control

Oala, Luis; Murchison, Andrew G.; Balachandran, Pradeep; Choudhary, Shruti; Fehr, Jana; Leite, Alixandro Werneck; Goldschmidt, Peter G.; Johner, Christian; Schörverth, Elora D. M.; Nakasi, Rose; Meyer, Martin; Cabitza, Federico; Baird, Pat; Prabhu, Carolin; Weicken, Eva; Liu, Xiaoxuan; Wenzel, Markus; Vogler, Steffen; Akogo, Darlington; Alsalamah, Shada; Kazim, Emre; Koshiyama, Adriano; Piechottka, Sven; Macpherson, Sheena; Shadforth, Ian; Geierhofer, Regina; Matek, Christian; Krois, Joachim; Sanguinetti, Bruno; Arentz, Matthew; Bielik, Pavol; Calderon‑Ramirez, Saul; Abbood, Auss; Langer, Nicolas; Haufe, Stefan; Kherif, Ferath; Pujari, Sameer; Samek, Wojciech; Wiegand, Thomas

Developers proposing new machine learning for health (ML4H) tools often pledge to match or even surpass the performance of existing tools, yet the reality is usually more complicated. Reliable deployment of ML4H to the ...

2021-11-12Zeitschriftenartikel

The Effect of Socioeconomic Factors and Indoor Residual Spraying on Malaria in Mangaluru, India: A Case-Control Study

Siegert, Konrad; van Loon, Welmoed; Gai, Prabhanjan P.; Rohmann, Jessica L.; Piccininni, Marco; Näher, Anatol-Fiete; Boloor, Archith; Shenoy, Damodara; Mahabala, Chakrapani; Kulkarni, Suyamindra S.; Kumar, Arun; Wedam, Jacob; Gai, Pramod; Devi, Rajeshwari; Jain, Animesh; Kurth, Tobias; Mockenhaupt, Frank P.

India faces 0.5 million malaria cases annually, including half of all Plasmodium vivax malaria cases worldwide. This case–control study assessed socioeconomic determinants of urban malaria in coastal Mangaluru, Karnataka, ...

2021-12-21Zeitschriftenartikel

Human Borna disease virus 1 (BoDV-1) encephalitis cases in the north and east of Germany

Frank, Christina; Wickel, Jonathan; Brämer, Dirk; Matschke, Jakob; Ibe, Richard; Gazivoda, Caroline; Günther, Albrecht; Hartmann, Christian; Rehn, Kordt; Cadar, Daniel; Mayer, Thomas E.; Pörtner, Kirsten; Wilking, Hendrik; Schmidt-Chanasit, Jonas; Tappe, Dennis

In 2021, three encephalitis cases due to the Borna disease virus 1 (BoDV-1) were diagnosed in the north and east of Germany. The patients were from the states of Thuringia, Saxony-Anhalt, and Lower Saxony. All were residents ...

2022-03-16Zeitschriftenartikel

Non-utilisation of health care services during the COVID-19 pandemic: Results of the CoMoLo study

Heidemann, Christin; Reitzle, Lukas; Schmidt, Christian; Fuchs, Judith; Prütz, Franziska; Scheidt-Nave, Christa

Based on data from the CORONA-MONITORING lokal (CoMoLo) study conducted in four municipalities particularly affected by the COVID-19 pandemic, this article investigates the non-utilisation of health care services in the ...

2022-01-20Zeitschriftenartikel

RNA reference materials with defined viral RNA loads of SARS-CoV-2—A useful tool towards a better PCR assay harmonization

Vierbaum, Laura; Wojtalewicz, Nathalie; Grunert, Hans-Peter; Lindig, Vanessa; Duehring, Ulf; Drosten, Christian; Corman, Victor; Niemeyer, Daniela; Ciesek, Sandra; Rabenau, Holger F.; Berger, Annemarie; Obermeier, Martin; Nitsche, Andreas; Michel, Janine; Mielke, Martin; Huggett, Jim; O’Sullivan, Denise; Busby, Eloise; Cowen, Simon; Vallone, Peter M.; Cleveland, Megan H.; Falak, Samreen; Kummrow, Andreas; Keller, Thomas; Schellenberg, Ingo; Zeichhardt, Heinz; Kammel, Martin

SARS-CoV-2, the cause of COVID-19, requires reliable diagnostic methods to track the circulation of this virus. Following the development of RT-qPCR methods to meet this diagnostic need in January 2020, it became clear ...

2022-02-02Zeitschriftenartikel

Construction and validation of safe Clostridium botulinum Group II surrogate strain producing inactive botulinum neurotoxin type E toxoid

Nowakowska, Maria B.; Selby, Katja; Przykopanski, Adina; Krüger, Maren; Krez, Nadja; Dorner, Brigitte G.; Dorner, Martin B.; Jin, Rongsheng; Minton, Nigel P.; Rummel, Andreas; Lindström, Miia

Botulinum neurotoxins (BoNTs), produced by the spore-forming bacterium Clostridium botulinum, cause botulism, a rare but fatal illness affecting humans and animals. Despite causing a life-threatening disease, BoNT is a ...

2022-02-02Zeitschriftenartikel

Advanced sequencing approaches detected insertions of viral and human origin in the viral genome of chronic hepatitis E virus patients

Papp, C.‑Patrick; Biedermann, Paula; Harms, Dominik; Wang, Bo; Kebelmann, Marianne; Choi, Mira; Helmuth, Johannes; Corman, Victor M.; Thürmer, Andrea; Altmann, Britta; Klink, Patrycja; Hofmann, Jörg; Bock, C.‑Thomas

The awareness of hepatitis E virus (HEV) increased significantly in the last decade due to its unexpectedly high prevalence in high-income countries. There, infections with HEV-genotype 3 (HEV-3) are predominant which can ...

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