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2022-01-08Zeitschriftenartikel
Changes in healthcare seeking and lifestyle in old aged individuals during COVID-19 lockdown in Germany: the population-based AugUR study 
Brandl, Caroline; Zimmermann, Martina E.; Günther, Felix; Dietl, Alexander; Küchenhoff, Helmut; Loss, Julika; Stark, Klaus J.; Heid, Iris M.
Background: Containment measures in the COVID-19 pandemic protected individuals at high risk, particularly individuals at old age, but little is known about how these measures affected health-related behavior of old ...
2021-12-23Zeitschriftenartikel
Numerical approaches for the rapid analysis of prophylactic efficacy against HIV with arbitrary drug-dosing schemes 
Zhang, Lanxin; Wang, Junyu; von Kleist, Max
Pre-exposure prophylaxis (PrEP) is an important pillar to prevent HIV transmission. Because of experimental and clinical shortcomings, mathematical models that integrate pharmacological, viral- and host factors are ...
2023-01-18Zeitschriftenartikel
Crystal structures of OrfX1, OrfX2 and the OrfX1–OrfX3 complex from the orfX gene cluster of botulinum neurotoxin E1 
Gao, Linfeng; Lam, Kwok-ho; Liu, Shun; Przykopanski, Adina; Lübke, Johanna; Qi, Ruifeng; Krüger, Maren; Nowakowska, Maria B.; Selby, Katja; Douillard, François P.; Dorner, Martin B.; Perry, Kay; Linström, Miia; Dorner, Brigitte G.; Rummel, Andreas; Jin, Rongsheng
Botulinum neurotoxins (BoNTs) are among the most lethal toxins known to humans, comprising seven established serotypes termed BoNT/A–G encoded in two types of gene clusters (ha and orfX) in BoNT-producing clostridia. The ...
2022-01-11Zeitschriftenartikel
Prioritizing health information for national health reporting - a Delphi study of the Joint Action on Health Information (InfAct) 
Fehr, Angela; Seeling, Stefanie; Hornbacher, Anselm; Thißen, Martin; Bogaert, Petronille; Delnord, Marie; Lyons, Ronan A.; Tijhuis, Mariken J.; Achterberg, Peter; Ziese, Thomas
Background Health information (HI) strategies exist in several EU Member States, however, they mainly focus on technical issues and improving governance rather than on content-related priority setting. There is also ...
2022-01-14Zeitschriftenartikel
SARS-CoV-2 outbreaks in hospitals and long-term care facilities in Germany: a national observational study 
Suwono, Beneditta; Steffen, Annika; Schweickert, Birgitta; Schönfeld, Viktoria; Brandl, Michael; Sandfort, Mirco; Willrich, Niklas; Eckmanns, Tim; Haller, Sebastian
Background Outbreaks of coronavirus disease (COVID-19) in hospitals and long-term care facilities (LTCFs) pose serious public health threats. We analysed how frequency and size of SARS-CoV-2 outbreaks in hospitals and ...
2023-02-10Zeitschriftenartikel
Situational pathogen avoidance mediates the impact of social connectedness on preventive measures during the COVID-19 pandemic 
Taubert, Frederike; Sprengholz, Philipp; Korn, Lars; Eitze, Sarah; Wiedermann, Marc; Betsch, Cornelia
During the COVID-19 pandemic, physical distancing was one of the more important behaviours for reducing the spread of the virus. The present study investigated the influence on pathogen avoidance of familiarity with other ...
2023-02-06Zeitschriftenartikel
Visualization of SARS-CoV-2 particles in naso/oropharyngeal swabs by thin section electron microscopy 
Laue, Michael; Hoffmann, Tobias; Michel, Janine; Nitsche, Andreas
Background SARS-CoV-2 replicates efficiently in the upper airways of humans and produces high loads of virus RNA and, at least in the initial phase after infection, many infectious virus particles. Studying virus ...
2022-01-13Zeitschriftenartikel
Cost-savings and potential cost-savings through the distribution of generic antiretroviral drugs within the statutory health insurance market of Germany between January 2017 and June 2019 
Lottes, Matthäus; Bremer, Viviane; Prugger, Christof; Christian, Kollan; Schmidt, Daniel
Background: Recent patent losses for antiretroviral drugs (ARV) have led to the debate of cost-saving through the replacement of patented drugs with generic drugs. The split of recommended single-tablet regimens (STR) ...
2023-11-23Zeitschriftenartikel
Auf dem Weg zum Ende von AIDS? Die HIV-Epidemie in Deutschland 
Ulrich, Marcus; Schmidt, Daniel; Gunsenheimer-Bartmeyer, Barbara; Bremer, Viviane
Vor 40 Jahren wurde das Humane Immundefizienz-Virus (HIV) erstmals als das Virus identifiziert und beschrieben, welches das erworbene Immunschwächesyndrom AIDS (Acquired Immunodeficiency Syndrome) verursacht. Vor diesem ...
2023-11-23Zeitschriftenartikel
Einfluss des Kriegs in der Ukraine auf gemeldete HIV-Neudiagnosen in Deutschland 
Koppe, Uwe; Hanke, Kirsten; Meixenberger, Karolin; Bremer, Viviane; Gunsenheimer- Bartmeyer, Barbara
Die HIV-Prävalenz in der Ukraine wurde im Jahr 2019 bezogen auf die Gesamtbevölkerung auf 0,9 – 1,0 % geschätzt, wobei die Prävalenz in bestimmten vulnerablen Gruppen deutlich höher liegen dürfte. Durch den Angriffskrieg ...
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