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2015-12-09Zeitschriftenartikel
Cytomegalovirus Seroprevalence Among Children and Adolescents in Germany: Data From the German Health Interview and Examination Survey for Children and Adolescents (KiGGS), 2003–2006 
Voigt, Sebastian; Rosario, Angelika Schaffrath; Mankertz, Annette
Background. Congenital cytomegalovirus (CMV) infection can cause severe birth defects. The majority of children with congenital CMV are born to CMV-seropositive women; however, transmission from mother to fetus and resulting ...
2016-01-12Zeitschriftenartikel
Enabling Precision Medicine With Digital Case Classification at the Point-of-Care 
Obermeier, Patrick; Muehlhans, Susann; Hoppe, Christian; Karsch, Katharina; Tief, Franziska; Chen, Xi; Conrad, Tim; Böttcher, Sindy; Diedrich, Sabine; Rath, Barbara
Infectious and inflammatory diseases of the central nervous system are difficult to identify early. Case definitions for aseptic meningitis, encephalitis, myelitis, and acute disseminated encephalomyelitis (ADEM) are ...
2016-03-01Zeitschriftenartikel
Assessment of Recombination in the S-segment Genome of Crimean-Congo Hemorrhagic Fever Virus in Iran 
Chinikar, Sadegh; Shah-Hosseini, Nariman; Bouzari, Saeid; Shokrgozar, Mohammad Ali; Mostafavi, Ehsan; Jalali, Tahmineh; Khakifirouz, Sahar; Groschup, Martin H.; Niedrig, Matthias
Background: Crimean-Congo Hemorrhagic Fever Virus (CCHFV) belongs to genus Nairovirus and family Bunyaviridae. The main aim of this study was to investigate the extent of recombination in S-segment genome of CCHFV in Iran. ...
2016-08-04Zeitschriftenartikel
Brucellosis in a refugee who migrated from Syria to Germany and lessons learnt, 2016 
Grunow, Roland; Jacob, Daniela; Klee, Silke; Schlembach, D.; Jackowski-Dohrmann, S.; Loenning-Baucke, V.; Eberspächer, B.; Swidsinski, S.
A teenage woman migrating from Syria arrived in May 2015 in Germany. She gave birth to a healthy child in early 2016, but became febrile shortly after delivery. Blood cultures revealed Brucella melitensis. In retrospect, ...
2016-08-08Zeitschriftenartikel
Epidemiological Data Management during an Outbreak of Ebola Virus Disease: Key Issues and Observations from Sierra Leone 
Owada, Kei; Eckmanns, Tim; Kamara, Kande-Bure O’Bai; Olu, Olushayo Oluseun
Sierra Leone experienced intense transmission of Ebola virus disease (EVD) from May 2014 to November 2015 during which a total of 8,704 confirmed cases and over 3,589 confirmed deaths were reported. Our field observation ...
2016-08-15Zeitschriftenartikel
Außergewöhnlicher Fall einer neonatalen Herpes-simplex-Virus-Infektion 
Robert Koch-Institut
2016-07-28Zeitschriftenartikel
Complete Genome Sequences of Two Methicillin-Sensitive Staphylococcus aureus Isolates Representing a Population Subset Highly Prevalent in Human Colonization 
Weber, Robert E.; Layer, Franziska; Fuchs, Stephan; Bender, Jennifer K.; Fiedler, Stefan; Werner, Guido; Strommenger, Birgit
Here, we report the high-quality draft genome sequences of two methicillin-susceptible Staphylococcus aureus isolates, 08-02119 and 08-02300. Belonging to sequence type 582 (ST582) and ST7, both isolates are representatives ...
2016-03-02Zeitschriftenartikel
Intestinal Cell Tight Junctions Limit Invasion of Candida albicans through Active Penetration and Endocytosis in the Early Stages of the Interaction of the Fungus with the Intestinal Barrier 
Goyer, Marianne; Loiselet, Alicia; Bon, Fabienne; L’Ollivier, Coralie; Laue, Michael; Holland, Gudrun; Bonnin, Alain; Dalle, Frederic
C. albicans is a commensal yeast of the mucous membranes in healthy humans that can also cause disseminated candidiasis, mainly originating from the digestive tract, in vulnerable patients. It is necessary to understand ...
2016-01-12Zeitschriftenartikel
A Follow-Up of the Multicenter Collaborative Study on HIV-1 Drug Resistance and Tropism Testing Using 454 Ultra Deep Pyrosequencing 
John, Elizabeth P. St.; Simen, Birgitte B.; Turenchalk, Gregory S.; Braverman, Michael S.; Abbate, Isabella; Aerssens, Jeroen; Bouchez, Olivier; Gabriel, Christian; Izopet, Jacques; Meixenberger, Karolin; Giallonardo, Francesca Di; Schlapbach, Ralph; Paredes, Roger; Sakwa, James; Schmitz-Agheguian, Gudrun G.; Thielen, Alexander; Victor, Martin; Metzner, Karin J.; Däumer, Martin P.
Background: Ultra deep sequencing is of increasing use not only in research but also in diagnostics. For implementation of ultra deep sequencing assays in clinical laboratories for routine diagnostics, intra- and ...
2016-03-17Zeitschriftenartikel
Carriage of Extended-Spectrum Beta-Lactamase-Plasmids Does Not Reduce Fitness but Enhances Virulence in Some Strains of Pandemic E. coli Lineages 
Schaufler, Katharina; Semmler, Torsten; Pickard, Derek J.; Toro, María de; Cruz, Fernando de la; Wieler, Lothar H.; Ewers, Christa; Guenther, Sebastian
Pathogenic ESBL-producing E. coli lineages occur frequently worldwide, not only in a human health context but in animals and the environment, also in settings with low antimicrobial pressures. This study investigated the ...
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