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2023-11-27ZeitschriftenartikelWhy are different estimates of the effective reproductive number so different? A case study on COVID-19 in Germany The effective reproductive number Rt has taken a central role in the scientific, political, and public discussion during the COVID-19 pandemic, with numerous real-time estimates of this quantity routinely published. ...
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2023-01-18ZeitschriftenartikelProtective effectiveness of previous SARS-CoV-2 infection and hybrid immunity against the omicron variant and severe disease: a systematic review and meta-regression Background: The global surge in the omicron (B.1.1.529) variant has resulted in many individuals with hybrid immunity (immunity developed through a combination of SARS-CoV-2 infection and vaccination). We aimed to ...
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2023-06-26ZeitschriftenartikelGenomic Evidence of mcr-1.26 IncX4 Plasmid Transmission between Poultry and Humans Colistin is still commonly used and misused in animal husbandry driving the evolution and dissemination of transmissible plasmid-mediated colistin resistance (mcr). mcr-1.26 is a rare variant and, so far, has only been ...
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2023-05-04ZeitschriftenartikelLessons from COVID-19 for rescalable data collection Novel data and analyses have had an important role in informing the public health response to the COVID-19 pandemic. Existing surveillance systems were scaled up, and in some instances new systems were developed to meet ...
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2023-07-31ZeitschriftenartikelAdvancing Precision Medicine in Myocarditis: Current Status and Future Perspectives in Endomyocardial Biopsy-Based Diagnostics and Therapeutic Approaches The diagnosis and specific and causal treatment of myocarditis and inflammatory cardiomyopathy remain a major clinical challenge. Despite the rapid development of new imaging techniques, endomyocardial biopsies remain the ...
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2023-10-14ZeitschriftenartikelCryptic susceptibility to penicillin/β-lactamase inhibitor combinations in emerging multidrug-resistant, hospital-adapted Staphylococcus epidermidis lineages Global spread of multidrug-resistant, hospital-adapted Staphylococcus epidermidis lineages underscores the need for new therapeutic strategies. Here we show that many S. epidermidis isolates belonging to these lineages ...
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2023-02-21ZeitschriftenartikelLate Embryogenesis Abundant Proteins Contribute to the Resistance of Toxoplasma gondii Oocysts against Environmental Stresses Toxoplasma gondii oocysts, which are shed in large quantities in the feces from infected felines, are very stable in the environment, resistant to most inactivation procedures, and highly infectious. The oocyst wall provides ...
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2023-01-24ZeitschriftenartikelFactsheet Epidemiologie metastasierter Tumoren in Deutschland, 2015–2019: Inzidenz und 5‑Jahres-Überleben
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2023-04-04ZeitschriftenartikelHeterozygosity for cervid S138N polymorphism results in subclinical CWD in gene-targeted mice and progressive inhibition of prion conversion Prions are proteinaceous infectious particles that replicate by structural conversion of the host-encoded cellular prion protein (PrPC), causing fatal neurodegenerative diseases in mammals. Species-specific amino acid ...
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2023-10-06ZeitschriftenartikelInteractive polar diagrams for model comparison Objective: Evaluating the performance of multiple complex models, such as those found in biology, medicine, climatology, and machine learning, using conventional approaches is often challenging when using various evaluation ...
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2023-07-28ZeitschriftenartikelInequalities in the burden of non-communicable diseases across European countries: a systematic analysis of the Global Burden of Disease 2019 study Background: Although overall health status in the last decades improved, health inequalities due to non-communicable diseases (NCDs) persist between and within European countries. There is a lack of studies giving ...
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2023-05-30ZeitschriftenartikelDetection of bornavirus-reactive antibodies and BoDV-1 RNA only in encephalitis patients from virus endemic areas: a comparative serological and molecular sensitivity, specificity, predictive value, and disease duration correlation study Purpose: Human Borna disease virus (BoDV-1) encephalitis is an emerging disease in Germany. This study investigates the spectrum of human BoDV-1 infection, characterizes anti-BoDV-1-antibodies and kinetics, and compares ...
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2023-09-07ZeitschriftenartikelMicroRNAs As Novel Biomarkers and Potential Therapeutic Options for Inflammatory Cardiomyopathy Aims: Inflammation of the heart is a complex biological and pathophysiological response of the immune system to a variety of injuries leading to tissue damage and heart failure. MicroRNAs (miRNAs) emerge as pivotal ...
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2026-01-22ZeitschriftenartikelEmpfehlungen der Ständigen Impfkommission (STIKO) beim Robert Koch-Institut 2026
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2023-01-07ZeitschriftenartikelSuccessful Treatment of Complicated Influenza A(H3N2) Virus Infection and Rhabdomyolysis with Compassionate Use of IV Zanamivir In 2019, EMA licensed intravenous (IV) zanamivir for severe influenza virus infection in children over 6 months as well as adults. Prior to that, it was possible via a compassionate use program. We present successful ...
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2023-04-19ZeitschriftenartikelNorovirus acute gastroenteritis amongst US and European travellers to areas of moderate to high risk of travellers’ diarrhoea: a prospective cohort study Background: Acute gastroenteritis (AGE) is a major medical condition for travellers worldwide, particularly travellers to low- and middle-income countries. Norovirus (NoV) is the most common cause of viral AGE in older ...
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2023-12-10ZeitschriftenartikelAreas with high HIV prevalence: A spatial analysis of nationwide claims data in Germany Objective: We aimed to identify spatial clusters of high HIV prevalence in Germany. Methods: Using nationwide outpatient claims data comprising information of about 88% of the total German population (N = 72 041 683), ...
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2023-11-09ZeitschriftenartikelLysinibacillus irui sp. nov., isolated from Iru, fermented African locust beans A Gram-positive, motile, aerobic, rod-shaped, endospore-forming strain designated IRB4-01T was isolated from fermented African locust beans (Iru) obtained from Bodija market in the city of Ibadan, southwestern Nigeria, ...
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2023-07-19ZeitschriftenartikelEnterovirus A71-associated acute flaccid paralysis in a pediatric patient: a case report Background: Enterovirus A71 is one of the causative agents of hand, foot, and mouth disease, which is usually a self-limiting disease. Complications of enterovirus infection are also very rare. However, when such ...
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2023-09-19ZeitschriftenartikelInternational harm reduction indicators are still not reached: results from a repeated cross-sectional study on drug paraphernalia distribution in Germany, 2021 Background: To prevent the transmission of blood-borne infections and reach the elimination of viral hepatitis by 2030, the World Health Organization (WHO) has set the goal to distribute 300 sterile needles and syringes ...