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2022-04-16ZeitschriftenartikelMulticentric Evaluation of SeeGene Allplex Real-Time PCR Assays Targeting 28 Bacterial, Microsporidal and Parasitic Nucleic Acid Sequences in Human Stool Samples Prior to the implementation of new diagnostic techniques, a thorough evaluation is mandatory in order to ensure diagnostic reliability. If positive samples are scarcely available, however, such evaluations can be difficult ...
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2022-04-29ZeitschriftenartikelTreatment trends for muscle-invasive bladder cancer in Germany from 2006 to 2019 Purpose: To examine national treatment trends of muscle-invasive bladder cancer (MIBC) in Germany with a special focus on radical cystectomy (RC). Patients and methods: Population-based data were derived from the ...
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2022-05-03ZeitschriftenartikelBaseline study for improving diagnostic stewardship at secondary health care facilities in Nigeria Background: Blood culture diagnostics are critical tools for sepsis management and antimicrobial resistance (AMR) surveillance. A baseline study was conducted to assess reported sepsis case finding, blood culture diagnostics, ...
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2022-05-07ZeitschriftenartikelBehavioral Health Risk Factors and Motivation to Change among Cardiovascular General Hospital Patients Aged 50 to 79 Years Little is known about the (co-)occurrence of smoking, alcohol at-risk drinking, physical inactivity and overweight, and the motivation to change these behavioral health risk factors (HRFs) in older general hospital patients ...
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2022-04-30ZeitschriftenartikelA dominant clonal lineage of Streptococcus uberis in cattle in Germany Bovine mastitis causes enormous economic losses in the dairy industry with Streptococcus uberis as one of the most common bacterial pathogens causing clinical and subclinical variations. In most cases mastitis can be cured ...
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2022-04-07ZeitschriftenartikelHIV pre-exposure prophylaxis was associated with no impact on sexually transmitted infection prevalence in a high-prevalence population of predominantly men who have sex with men, Germany, 2018 to 2019 Introduction: Despite increased use of pre-exposure prophylaxis (PrEP) in Germany, HIV infection rates are not declining and little is known about how this prevention method affects the prevalence of sexually transmitted ...
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2022-04-24ZeitschriftenartikelImported Pet Reptiles and Their “Blind Passengers”—In-Depth Characterization of 80 Acinetobacter Species Isolates Reptiles are popular pet animals and important food sources, but the trade of this vertebrate class is—besides welfare and conservation—under debate due to zoonotic microbiota. Ninety-two shipments of live reptiles were ...
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2022-06-16ZeitschriftenartikelRKI-Ratgeber HIV/ AIDS Die durch das Humane Immundefizienz-Virus (HIV) ausgelöste AIDS-Erkrankung wurde 1981 anhand klinischer und immunolo¬gischer Charakteristika als neu auftretendes Krankheitsbild unbekannter Ätiologie beschrieben. Seit seiner ...
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2022-03-16ZeitschriftenartikelExclusion of Mucorales Co-Infection in a Patient with Aspergillus flavus Sinusitis by Fluorescence In Situ Hybridization (FISH) Invasive fungal infections are associated with increased mortality in hematological patients. Despite considerable advances in antifungal therapy, the evaluation of suspected treatment failure is a common clinical challenge ...
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2022-04-05ZeitschriftenartikelThe Evolution of Complex Muscle Cell In Vitro Models to Study Pathomechanisms and Drug Development of Neuromuscular Disease Many neuromuscular disease entities possess a significant disease burden and therapeutic options remain limited. Innovative human preclinical models may help to uncover relevant disease mechanisms and enhance the translation ...
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2022-04-02ZeitschriftenartikelParamyxovirus Diversity within One Population of Miniopterus fuliginosus Bats in Sri Lanka Bats are known as typical reservoirs for a number of viruses, including viruses of the family Paramyxoviridae. Representatives of the subfamily Orthoparamyxovirinae are distributed worldwide and can cause mild to fatal ...
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2022-04-07ZeitschriftenartikelHIV, STI and renal function testing frequency and STI history among current users of self-funded HIV pre-exposure prophylaxis, a cross-sectional study, Germany, 2018 and 2019 Introduction: Users of pre-exposure prophylaxis (PrEP) require periodic testing for HIV, sexually transmitted infections (STI) and renal function. Before PrEP was made free of charge through statutory health insurance in ...
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2022-06-09ZeitschriftenartikelIn(tra)-Action Review (IAR): COVID-19-Management an IGV-benannten Flughäfen in Deutschland, September 2020 bis Mai 2021 Die Maßnahmen zur Eindämmung der COVID-19-Pandemie haben auch den Luftfahrtsektor stark beeinflusst und die zuständigen Gesundheitsbehörden vor neue Herausforderungen gestellt. Unter Federführung des RKI wurde am 20.05.2021 ...
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2022-06-08ZeitschriftenartikelSocial, health-related, and environmental factors influencing sleep problems of children, adolescents and young adults Sleep is a relevant factor for functioning and well-being of young people. The paper provides a differentiated description of sleep difficulties in this population group including social, health-related, and environmental ...
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2022-06-08ZeitschriftenartikelSoziale, gesundheitliche und umweltbedingte Einflussfaktoren auf Schlafprobleme von Jugendlichen und jungen Erwachsenen Schlaf ist ein relevanter Faktor für Leistungsfähigkeit und Wohlbefinden junger Menschen. Der Beitrag liefert eine differenzierte Beschreibung von Schlafschwierigkeiten in dieser Bevölkerungsgruppe unter Einbezug von ...
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2022-03-28ZeitschriftenartikelShort- and long-range interactions in the HIV-1 5′ UTR regulate genome dimerization and packaging RNA dimerization is the noncovalent association of two human immunodeficiency virus-1 (HIV-1) genomes. It is a conserved step in the HIV-1 life cycle and assumed to be a prerequisite for binding to the viral structural ...
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2022-04-26ZeitschriftenartikelPotential of prevention strategies for the modifiable risk factor type 2 diabetes with relation to the future number of dementia patients in Germany– a multi-state projection through 2040 Background: We assess the impact of prevention strategies regarding type 2 diabetes as a modifiable risk factor for dementia and its consequences for the future number of dementia patients in Germany. Methods: We used ...
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2022-06-02ZeitschriftenartikelSynopse virologischer Analysen im Nationalen Referenzzentrum für Influenzaviren während der COVID-19-Pandemie Das Nationale Referenzzentrum für Influenzaviren gewinnt durch die fortlaufende Untersuchung von Proben aus den Sentinelpraxen der Arbeitsgemeinschaft Influenza einen umfassenden Überblick über die zirkulierenden ...
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2022-03-16ZeitschriftenartikelPhylogenetic estimation of the viral fitness landscape of HIV-1 set-point viral load Set-point viral load (SPVL), a common measure of human immunodeficiency virus (HIV)-1 virulence, is partially determined by viral genotype. Epidemiological evidence suggests that this viral property has been under stabilising ...
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2022-03-31ZeitschriftenartikelRadiation exposure by medical X-ray applications Background: Radioactive material and ionising radiation play a central role in medical diagnostics and therapy. The benefit of ionising radiation is opposed by the risk of irreparable damage of the human organism. This ...