Browsing Artikel in Fachzeitschriften by Title
Now showing items 3428-3447 of 3770
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2021-02-10ZeitschriftenartikelToward an Integrated Genome-Based Surveillance of Salmonella enterica in Germany Despite extensive monitoring programs and preventative measures, Salmonella spp. continue to cause tens of thousands human infections per year, as well as many regional and international food-borne outbreaks, that are of ...
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2015-03-23ZeitschriftenartikelTowards a framework for evaluating and grading evidence in public health The Project on a Framework for Rating Evidence in Public Health (PRECEPT) is an international collaboration of public health institutes and universities which has been funded by the European Centre for Disease Prevention ...
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2011-01-01ZeitschriftenartikelTowards an AIDS vaccine: The transmembrane envelope protein as target for broadly neutralizing antibodies Although the development of an effective vaccine is the main goal in the fight against AIDS, all attempts by numerous laboratories to develop a vaccine have failed so far. In addition, it is still unclear whether cytotoxic ...
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2013-03-11ZeitschriftenartikelTowards further reduction and replacement of animal bioassays in prion research by cell and protein misfolding cyclic amplification assays Laboratory animals have long since been used extensively in bioassays for prions in order to quantify, usually in terms of median infective doses [ID50], how infectious these pathogens are in vivo. The identification of ...
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2021-06-01ZeitschriftenartikelTowards the characterization of the hidden world of small proteins in Staphylococcus aureus, a proteogenomics approach Small proteins play essential roles in bacterial physiology and virulence, however, automated algorithms for genome annotation are often not yet able to accurately predict the corresponding genes. The accuracy and reliability ...
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2021-12-21ZeitschriftenartikelToxoplasma gondii apicoplast-resident ferredoxin is an essential electron transfer protein for the MEP isoprenoid-biosynthetic pathway Apicomplexan parasites, such as Toxoplasma gondii, are unusual in that each cell contains a single apicoplast, a plastid- like organelle that compartmentalizes enzymes involved in the essential 2C-methyl-D-erythritol ...
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2019-05-23ZeitschriftenartikelToxoplasmosis in Germany: Epidemiology, Diagnosis, Risk Factors, and Treatment Background: With approximately 30% of the world population infected, Toxoplasma gondii is one of the most widespread pathogenic parasites in both humans and animals and a major problem for health economics in many ...
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2009-05-20ZeitschriftenartikelTracing the HIV-1 subtype B mobility in Europe: a phylogeographic approach Background: The prevalence and the origin of HIV-1 subtype B, the most prevalent circulating clade among the long-term residents in Europe, have been studied extensively. However the spatial diffusion of the epidemic ...
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2015-10-07ZeitschriftenartikelTracing the Spread of Clostridium difficile Ribotype 027 in Germany Based on Bacterial Genome Sequences We applied whole-genome sequencing to reconstruct the spatial and temporal dynamics underpinning the expansion of Clostridium difficile ribotype 027 in Germany. Based on re-sequencing of genomes from 57 clinical C. difficile ...
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2018-09-26ZeitschriftenartikelTracking of Blood Pressure in Children and Adolescents in Germany in the Context of Risk Factors for Hypertension Blood pressure (BP) tracking from childhood to adulthood has two aspects: the ranking stability relative to others over time and the prediction of future values. This study investigates BP tracking in children and adolescents ...
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2021-05-19ZeitschriftenartikelTracking the international spread of SARS-CoV-2 lineages B.1.1.7 and B.1.351/501Y-V2 Late in 2020, two genetically-distinct clusters of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with mutations of biological concern were reported, one in the United Kingdom and one in South Africa. Using ...
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2021-09-17ZeitschriftenartikelTracking the international spread of SARS-CoV-2 lineages B.1.1.7 and B.1.351/501Y-V2 with grinch (updated) Late in 2020, two genetically-distinct clusters of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with mutations of biological concern were reported, one in the United Kingdom and one in South Africa. Using ...
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2009-08-06ZeitschriftenartikelTranscription of the phage-encoded Panton–Valentine leukocidin of Staphylococcus aureus is dependent on the phage life-cycle and on the host background Panton-Valentine leukocidin (PVL) is a pore-forming, bi-component toxin secreted by Staphylococcus aureus strains epidemiologically associated with diseases such as necrotizing pneumonia and skin and soft-tissue infections. ...
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2021-12-14ZeitschriftenartikelTranscriptional Active Parvovirus B19 Infection Predicts Adverse Long-Term Outcome in Patients with Non-Ischemic Cardiomyopathy Parvovirus B19 (B19V) is the predominant cardiotropic virus currently found in endomyocardial biopsies (EMBs). However, direct evidence showing a causal relationship between B19V and progression of inflammatory cardiomyopathy ...
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2021-05-18ZeitschriftenartikelTransformation of microbiology data into a standardised data representation using OpenEHR The spread of multidrug resistant organisms (MDRO) is a global healthcare challenge. Nosocomial outbreaks caused by MDRO are an important contributor to this threat. Computer-based applications facilitating outbreak detection ...
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2017-06-07ZeitschriftenartikelTranslational Rodent Models for Research on Parasitic Protozoa—A Review of Confounders and Possibilities Rodents, in particular Mus musculus, have a long and invaluable history as models for human diseases in biomedical research, although their translational value has been challenged in a number of cases. We provide some ...
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2021-04-24ZeitschriftenartikelTransmissible α-synuclein seeding activity in brain and stomach of patients with Parkinson’s disease Cerebral deposition of abnormally aggregated α-synuclein (αSyn) is a neuropathological hallmark of Parkinson’s disease (PD). PD-associated αSyn (αSynPD) aggregates can act as proteinaceous nuclei (“seeds”) able of ...
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2013-12-12ZeitschriftenartikelTransmission and molecular characterisation of wild measles virus in Romania, 2008 to 2012 Molecular characterisation of measles virus is a powerful tool for tracing transmission. Genotyping may prove the absence of endemic circulation of measles virus, i.e. transmission for more than 12 months, which is one of ...
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2009-12-04ZeitschriftenartikelTransmission dynamics of pulmonary tuberculosis between autochthonous and immigrant sub-populations Background: The overall incidence of tuberculosis (TB) in Western Europe has been declining since the 19th Century. However, immigrant sub-groups from high-prevalence countries are slowing down this trend. The aim of this ...
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2009-11-15ZeitschriftenartikelTransmission of Drug‐Resistant HIV‐1 is Stabilizing in Europe The SPREAD Programme investigated prospectively the time trend from September 2002 through December 2005 of transmitted drug resistance (TDR) among 2793 patients in 20 European countries and in Israel with newly diagnosed ...