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Now showing items 1731-1740 of 3394

2003-01-01Zeitschriftenartikel

Expression of ICOS In Vivo Defines CD4+ Effector T Cells with High Inflammatory Potential and a Strong Bias for Secretion of Interleukin 10

Löhning, Max; Hutloff, Andreas; Kallinich, Tilmann; Mages, Hans Werner; Bonhagen, Kerstin; Radbruch, Andreas; Hamelmann, Eckard; Kroczek, Richard

The studies performed to date analyzed the overall participation of the inducible costimulator (ICOS) in model diseases, but did not yield information on the nature and function of ICOS-expressing T cells in vivo. We ...

2014-02-04Zeitschriftenartikel

Phylogenetic Analysis of Staphylococcus aureus CC398 Reveals a Sub-Lineage Epidemiologically Associated with Infections in Horses

Abdelbary, Mohamed M. H.; Wittenberg, Anne; Cuny, Christiane; Layer, Franziska; Kurt, Kevin; Wieler, Lothar H.; Walther, Birgit; Skov, Robert; Larsen, Jesper; Hasman, Henrik; Fitzgerald, J. Ross; Smith, Tara C.; Wagenaar, J. A.; Pantosti, Annalisa; Hallin, Marie; Struelens, Marc J.; Edwards, Giles; Böse, R.; Nübel, Ulrich; Witte, Wolfgang

In the early 2000s, a particular MRSA clonal complex (CC398) was found mainly in pigs and pig farmers in Europe. Since then, CC398 has been detected among a wide variety of animal species worldwide. We investigated the ...

2014-02-11Zeitschriftenartikel

High prevalence and diversity of species D adenoviruses (HAdV-D) in human populations of four Sub-Saharan countries

Pauly, Maude; Hoppe, Eileen; Mugisha, Lawrence; Petrzelkova, Klara; Akoua-Koffi, Chantal; Couacy-Hymann, Emmanuel; Anoh, Augustin Etile; Mossoun, Arsène; Schubert, Grit; Wiersma, Lidewij; Pascale, Sabwe; Muyembe, Jean-Jacques; Karhemere, Stomy; Weiss, Sabrina; Leendertz, Siv Aina; Calvignac-Spencer, Sébastien; Leendertz, Fabian; Ehlers, Bernhard

Background: Human adenoviruses of species D (HAdV-D) can be associated with acute respiratory illness, epidemic keratoconjunctivitis, and gastroenteritis, but subclinical HAdV-D infections with prolonged shedding have ...

2014-02-19Zeitschriftenartikel

Human Papillomavirus prevalence and probable first effects of vaccination in 20 to 25 year-old women in Germany: a population-based cross-sectional study via home-based self-sampling

Deleré, Yvonne; Remschmidt, Cornelius; Leuschner, Josefine; Schuster, Melanie; Fesenfeld, Michaela; Schneider, Achim; Wichmann, Ole; Kaufmann, Andreas M.

Background: Estimates of Human Papillomavirus (HPV) prevalence in a population prior to and after HPV vaccine introduction are essential to evaluate the short-term impact of vaccination. Methods: Between 2010 and ...

2014-01-30Zeitschriftenartikel

Internet-based syndromic monitoring of acute respiratory illness in the general population of Germany, weeks 35/2011 to 34/2012

Bayer, Christophe; Remschmidt, Cornelius; Heiden, Matthias an der; Tolksdorf, Kristin; Herzhoff, Michael; Kärsten, Sebastian; Buda, Silke; Haas, Walter; Buchholz, Udo

In March 2011, the German sentinel surveillance system for influenza (Arbeitsgemeinschaft Influenza (AGI)) was complemented by an Internet-based syndromic monitoring system (GrippeWeb) for acute respiratory infections (ARI) ...

2014-02-01Zeitschriftenartikel

Vaccination coverage among children in Germany estimated by analysis of health insurance claims data

Rieck, Thorsten; Feig, Marcel; Eckmanns, Tim; Benzler, Justus; Siedler, Anette; Wichmann, Ole

In Germany, the national routine childhood immunization schedule comprises 12 vaccinations. Primary immunizations should be completed by 24 mo of age. However, nationwide monitoring of vaccination coverage (VC) is performed ...

2013-09-26Zeitschriftenartikel

Health economic evaluation of vaccination strategies for the prevention of herpes zoster and postherpetic neuralgia in Germany

Ultsch, Bernhard; Weidemann, Felix; Reinhold, Thomas; Siedler, Anette; Krause, Gérard; Wichmann, Ole

Background: Herpes zoster (HZ) is a self-limiting painful skin rash affecting mostly individuals from 50 years of age. The main complication is postherpetic neuralgia (PHN), a long-lasting pain after rash has resolved. ...

2013-09-25Zeitschriftenartikel

Diagnosis of West Nile Virus Human Infections: Overview and Proposal of Diagnostic Protocols Considering the Results of External Quality Assessment Studies

Sambri, Vittorio; Capobianchi, Maria R.; Cavrini, Francesca; Charrel, Rémi; Mantke, Oliver Donoso; Escadafal, Camille; Franco, Leticia; Gaibani, Paolo; Gould, Ernest A.; Niedrig, Matthias; Papa, Anna; Pierro, Anna; Rossini, Giada; Sanchini, Andrea; Tenorio, Antonio; Varani, Stefania; Vázquez, Ana; Vocale, Caterina; Zeller, Hervé

West Nile virus, genus Flavivirus, is transmitted between birds and occasionally other animals by ornithophilic mosquitoes. This virus also infects humans causing asymptomatic infections in about 85% of cases and

2013-09-06Zeitschriftenartikel

Enterohemorrhagic Escherichia coli as Causes of Hemolytic Uremic Syndrome in the Czech Republic

Marejková, Monika; Bláhová, Květa; Janda, Jan; Fruth, Angelika; Petráš, Petr

Background: Enterohemorrhagic Escherichia coli (EHEC) cause diarrhea-associated hemolytic uremic syndrome (D+ HUS) worldwide, but no systematic study of EHEC as the causative agents of HUS was performed in the Czech ...

2013-04-15Zeitschriftenartikel

Giardia duodenalis arginine deiminase modulates the phenotype and cytokine secretion of human dendritic cells by depletion of arginine and formation of ammonia

Banik, Stefanie; Viveros, Pablo Renner; Seeber, Frank; Klotz, Christian; Ignatius, Ralf; Aebischer, Toni

Depletion of arginine is a recognized strategy that pathogens use to evade immune effector mechanisms. Depletion depends on microbial enzymes such as arginases, which are considered virulence factors. The effect is mostly ...

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