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2011-11-30Zeitschriftenartikel
Genome analysis of bat adenovirus 2: Indications of interspecies transmission 
Kohl, Claudia; Vidovszky, Márton Z.; Mühldorfer, Kristin; Dabrowski, Piotr Wojtek; Radonić, Aleksandar; Nitsche, Andreas; Wibbelt, Gudrun; Kurth, Andreas; Harrach, Balázs
The genome of bat adenovirus 2 was sequenced and analyzed. It is similar in size (31,616 bp) to the genomes of bat adenovirus 3 and canine adenoviruses 1 and 2. These four viruses are monophyletic and share an identical ...
2012-01-18Zeitschriftenartikel
Evaluation of adding a second marker to overcome Staphylococcus aureus spa-typing homoplasies 
Basset, P.; Nübel, Ulrich; Witte, Wolfgang; Blanc, D. S.
The utility of sequencing a second highly variable locus in addition to the spa gene (e.g., double-locus sequence typing [DLST]) was investigated to overcome limitations of a Staphylococcus aureus single-locus typing method. ...
2011-12-09Zeitschriftenartikel
Absence of Livestock-Associated Methicillin-Resistant Staphylococcus aureus Clonal Complex CC398 as a Nasal Colonizer of Pigs Raised in an Alternative System 
Cuny, Christiane; Friedrich, Alexander W.; Witte, Wolfgang
Livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) ST398 isolated from pigs raised in conventional farms was previously reported. Here we report a study on 25 farms adhering to an alternative system. ...
2010-11-10Zeitschriftenartikel
The Presence of a vpu Gene and the Lack of Nef-Mediated Downmodulation of T Cell Receptor-CD3 Are Not Always Linked in Primate Lentiviruses 
Schmökel, Jan; Sauter, Daniel; Schindler, Michael; Leendertz, Fabian; Bailes, Elizabeth; Dazza, Marie-Christine; Saragosti, Sentob; Bibollet-Ruche, Frederic; Peeters, Martine; Hahn, Beatrice H.; Kirchhoff, Frank
Nef is an accessory protein critical for the ability of human and simian immunodeficiency viruses (HIV and SIV) to replicate efficiently in their respective hosts. Previous analyses of members of 15 different primate ...
2010-05-04Zeitschriftenartikel
Isotopologue Profiling of Legionella pneumophila 
Role of Serine and Glucose as Carbon Substrates
Eylert, Eva; Herrmann, Vroni; Jules, Matthieu; Gillmaier, Nadine; Lautner, Monika; Buchrieser, Carmen; Eisenreich, Wolfgang; Heuner, Klaus
Legionella pneumophila (Lp) is commonly found in freshwater habitats but is also the causative agent of Legionnaires' disease when infecting humans. Although various virulence factors have been reported, little is known ...
2010-09-24Zeitschriftenartikel
Characterization of Yersinia using MALDI-TOF mass spectrometry and chemometrics. 
Lasch, Peter; Drevinek, Michal; Nattermann, Herbert; Grunow, Roland; Stämmler, Maren; Dieckmann, Ralf; Schwecke, Torsten; Naumann, Dieter
Yersinia are Gram-negative, rod-shaped facultative anaerobes, and some of them, Yersinia enterocolitica, Yersinia pseudotuberculosis, and Yersinia pestis, are pathogenic in humans. Rapid and accurate identification of ...
2010-05-04Zeitschriftenartikel
Bestimmung von Impfquoten und Inzidenzen von Erkrankungen anhand von Daten der Kassenärztlichen Vereinigungen 
Determination of Vaccination Coverage and Disease Incidence using Statutory Health Insurance Data
Reuss, Annicka; Feig, Marcel; Kappelmayer, Lutz; Eckmanns, Tim; Poggensee, Gabriele
Hintergrund: Im Rahmen des KV-Sentinels, einem gemeinsamen Projekt des Robert Koch-Instituts und der 17 Kassenärztlichen Vereinigungen, werden seit 2004 pseudonymisierte Abrechnungsdaten von den Kassenärztlichen Vereinigungen ...
2010-05-24Zeitschriftenartikel
Inducible costimulator (ICOS) blockade inhibits accumulation of polyfunctional T helper 1/T helper 17 cells and mitigates autoimmune arthritis 
Frey, Oliver; Meisel, Juliane; Hutloff, Andreas; Bonhagen, Kerstin; Bruns, Lisa; Kroczek, Richard; Morawietz, Lars; Kamradt, Thomas
Objectives: Inducible costimulator (ICOS) and its ligand (ICOSL) regulate T and B cell responses. Glucose-6-phosphate isomerase (G6PI)-induced arthritis requires T and B lymphocytes. It was hypothesised that blocking ...
2011-01-01Zeitschriftenartikel
Towards an AIDS vaccine: The transmembrane envelope protein as target for broadly neutralizing antibodies 
Denner, Joachim
Although the development of an effective vaccine is the main goal in the fight against AIDS, all attempts by numerous laboratories to develop a vaccine have failed so far. In addition, it is still unclear whether cytotoxic ...
2011-09-14Zeitschriftenartikel
Influenza B Virus With Modified Hemagglutinin Cleavage Site as a Novel Attenuated Live Vaccine 
Stech, Jürgen; Garn, Holger; Herwig, Astrid; Stech, Olga; Dauber, Bianca; Wolff, Thorsten; Mettenleiter, Thomas C.; Klenk, Hans-Dieter
Background: Both pandemic and interpandemic influenza is associated with high morbidity and mortality worldwide. Seasonal epidemics are caused by both influenza A and B virus strains that cocirculate with varying predominance ...
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