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2018-05-17Zeitschriftenartikel

Negligible import of enteric pathogens by newly arrived asylum seekers and no impact on incidence of notified Salmonella and Shigella infections and outbreaks in Rhineland-Palatinate, Germany, January 2015 to May 2016

Ehlkes, Lutz; George, Maja; Knautz, Donald; Burckhardt, Florian; Jahn, Klaus; Vogt, Manfred; Zanger, Philipp

Introduction The 2015 refugee crisis raised concerns about an import of infectious diseases affecting the German population. Aims: To evaluate public and individual health benefits of stool screening, and explore whether ...

2018-07-19Zeitschriftenartikel

Retrospective clinical case series study in 2017 identifies Plasmodium knowlesi as most frequent Plasmodium species in returning travellers from Thailand to Germany

Froeschl, Guenter; Nothdurft, Hans Dieter; von Sonnenburg, Frank; Bretzel, Gisela; Polanetz, Roman; Kroidl, Inge; Seilmaier, Michael; Orth, Hans Martin; Jordan, Sabine; Kremsner, Peter; Vygen-Bonnet, Sabine; Pritsch, Michael; Hoelscher, Michael; Rothe, Camilla

Febrile illnesses are common in travellers returning from south-east Asia. However, malaria is a rare diagnosis in this population. A series of Plasmodium knowlesi infections was noted in German travellers returning from ...

2018-03-22Zeitschriftenartikel

Field investigation with real-time virus genetic characterisation support of a cluster of Ebola virus disease cases in Dubréka, Guinea, April to June 2015

Pini, Alessandro; Zomahoun, Delayo; Duraffour, Sophie; Derrough, Tarik; Charles, Myrna; Quick, Joshua; Loman, Nick; Cowley, Lauren; Leno, Mamadou; Ouedraogo, Nobila; Thiam, Oumou; Hernández-Romieu, Alfonso; Iko, Annie; Keita, Halimatou; Konate, Djiba; Soumah, Aboubacar Aboubak; Bouchouar, Etran; Ileka-Priouzeau, Samuel; Keita, Sakoba; Diallo, Boubacar; Cisse, Fode; Jansa, Josep; Carroll, Miles; Günther, Stephan; Severi, Ettore; Formenty, Pierre

On 11 May 2015, the Dubréka prefecture, Guinea, reported nine laboratory-confirmed cases of Ebola virus disease (EVD). None could be epidemiologically linked to cases previously reported in the prefecture. We describe the ...

2019-03-04Zeitschriftenartikel

Characterization of a hepatitis C virus genotype 1 divergent isolate from an HIV-1 coinfected individual in Germany assigned to a new subtype 1o

Wang, Bo; Krüger, Luise; Machnowska, Patrycja; Eshetu, Amare; Gunsenheimer-Bartmeyer, Barbara; Bremer, Viviane; Hauser, Andrea; Bannert, Norbert; Bock, C. Thomas

Background HCV exhibits a high genetic diversity and is classified into 7 genotypes which are further divided into 86 confirmed subtypes. However, there are multiple isolates with unassigned subtypes. We aimed to amplify ...

2018-07-12Zeitschriftenartikel

Need for additional capacity and improved capability for molecular detection of yellow fever virus in European Expert Laboratories: External Quality Assessment, March 2018

Domingo, Cristina; Ellerbrok, Heinz; Koopmans, Marion; Nitsche, Andreas; Leitmeyer, Katrin; Charrel, Rémi N.; Reusken, Chantal B.

An external quality assessment of yellow fever virus (YFV) molecular detection in European laboratories was organised in rapid response to an increase in human cases in Brazil in 2018 with risk of import to Europe. Detection ...

2018-07-05Zeitschriftenartikel

Two concurrent outbreaks of hepatitis A highlight the risk of infection for non-immune travellers to Morocco, January to June 2018

Gassowski, Martyna; Michaelis, Kai; Wenzel, Jürgen J.; Faber, Mirko; Figoni, Julie; Mouna, Lina; Friesema, Ingrid H. M.; Vennema, Harry; Avellon, Ana; Varela, Carmen; Sundqvist, Lena; Lundberg Ederth, Josefine; Plunkett, James; Balogun, Koye; Ngui, Siew Lin; Midgley, Sofie Elisabeth; Gillesberg Lassen, Sofie; Müller, Luise

From January to June 2018, two ongoing hepatitis A outbreaks affected travellers returning from Morocco and cases in Europe without travel history, resulting in 163 patients in eight European countries. Most interviewed ...

2018-11-02Zeitschriftenartikel

Update on prevalence and mechanisms of resistance to linezolid, tigecycline and daptomycin in enterococci in Europe: Towards a common nomenclature

Bender, Jennifer K.; Cattoir, Vincent; Hegstad, Kristin; Sadowy, Ewa; Coque, Teresa M.; Westh, Henrik; Hammerum, Anette M.; Schaffer, Kirsten; Burns, Karen; Murchan, Stephen; Novais, Carla; Freitas, Ana R.; Peixe, Luísa; Del Grosso, Maria; Pantosti, Annalisa; Werner, Guido

Vancomycin-resistant enterococci (VRE) are important nosocomial pathogens. Invasive VRE infections are difficult to treat since common therapeutic options including ampicillin and glycopeptides often fail. In vitro, most ...

2019-03-08Zeitschriftenartikel

Global monitoring of antimicrobial resistance based on metagenomics analyses of urban sewage

Hendriksen, Rene S.; Munk, Patrick; Njage, Patrick; van Bunnik, Bram; McNally, Luke; Lukjancenko, Oksana; Röder, Timo; Nieuwenhuijse, David; Karlsmose Pedersen, Susanne; Kjeldgaard, Jette; Kaas, Rolf S.; Lanken Conradsen Clausen, Philip Thomas; Vogt, Josef Korbinian; Leekitcharoenphon, Pimlapas; van de Schans, Milou G. M.; Zuidema, Tina; de Roda Husman, Ana Maria; Rasmussen, Simon; Petersen, Bent; The Global Sewage Surveillance project consortium; Amid, Clara; Cochrane, Guy; Sicheritz-Ponten, Thomas; Schmitt, Heike; Alvarez, Jorge Raul Matheu; Aidara-Kane, Awa; Pamp, Sünje J.; Lund, Ole; Hald, Tine; Woolhouse, Mark; Koopmans, Marion P.; Vigre, Håkan; Nordahl Petersen, Thomas; Aarestrup, Frank M.

Antimicrobial resistance (AMR) is a serious threat to global public health, but obtaining representative data on AMR for healthy human populations is difficult. Here, we use metagenomic analysis of untreated sewage to ...

2018-02-02Zeitschriftenartikel

Mendelian adult-onset leukodystrophy genes in Alzheimer's disease: critical influence of CSF1R and NOTCH3

Sassi, Celeste; Nalls, Michael A.; Ridge, Perry G.; Gibbs, Jesse R.; Lupton, Michelle K.; Troakes, Claire; Lunnon, Katie; Al-Sarraj, Safa; Brown, Kristelle S.; Medway, Christopher; Lord, Jenny; Turton, James; Bras, Jose; Passmore, Peter; Craig, David; Johnston, Janet; McGuinness, Bernadette; Todd, Stephen; Heun, Reinhard; Kölsch, Heike; Kehoe, Patrick G.; Vardy, Emma R. L. C.; Hooper, Nigel M.; Smith, A. David; Wilcock, Gordon; Warden, Donald; Holmes, Clive; Blumenau, Sonja; Thielke, Mareike; Josties, Christa; Freyer, Dorette; Dietrich, Annette; Hammer, Monia; Baier, Michael; Dirnagl, Ulrich; Morgan, Kevin; Powell, John F.; Kauwe, John S.; Cruchaga, Carlos; Goate, Alison M.; Singleton, Andrew B.; Guerreiro, Rita; Hodges, Angela; Hardy, John

Mendelian adult-onset leukodystrophies are a spectrum of rare inherited progressive neurodegenerative disorders affecting the white matter of the central nervous system. Among these, cerebral autosomal dominant and recessive ...

2018-10-22Zeitschriftenartikel

Bringing together what belongs together: Optimizing murine infection models by using mouse-adapted Staphylococcus aureus strains

Trübe, Patricia; Hertlein, Tobias; Mrochen, Daniel M.; Schulz, Daniel; Jorde, Ilka; Krause, Bettina; Zeun, Julia; Fischer, Stefan; Wolf, Silver A.; Walther, Birgit; Semmler, Torsten; Bröker, Barbara M.; Ulrich, Rainer G.; Ohlsen, Knut; Holtfreter, Silva

Staphylococcus (S.) aureus is a leading cause of bacterial infection world-wide, and currently no vaccine is available for humans. Vaccine development relies heavily on clinically relevant infection models. However, the ...

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