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2019-12-29Zeitschriftenartikel
A Comprehensive Strategy for Screening for Xenotransplantation-Relevant Viruses in a Second Isolated Population of Göttingen Minipigs 
Krüger, Luise; Kristiansen, Yannick; Reuber, Emelie; Möller, Lars; Laue, Michael; Reimer, Christian; Denner, Joachim
Xenotransplantation using pig tissues and organs is under development in order to alleviate the increasing shortage of human transplants. Since xenotransplantation may be associated with the transmission of porcine ...
2020-01-24Zeitschriftenartikel
Molecular Epidemiology of Methicillin-Susceptible and Methicillin-Resistant Staphylococcus aureus in Wild, Captive and Laboratory Rats: Effect of Habitat on the Nasal S. aureus Population 
Raafat, Dina; Mrochen, Daniel M.; Al'Sholui, Fawaz; Heuser, Elisa; Ryll, René; Pritchett-Corning, Kathleen R.; Jacob, Jens; Walther, Bernd; Matuschka, Franz-Rainer; Richter, Dania; Westerhüs, Uta; Pikula, Jiri; van den Brandt, Jens; Nicklas, Werner; Monecke, Stefan; Strommenger, Birgit; van Alen, Sarah; Becker, Karsten; Ulrich, Rainer G.; Holtfreter, Silva
Rats are a reservoir of human- and livestock-associated methicillin-resistant Staphylococcus aureus (MRSA). However, the composition of the natural S. aureus population in wild and laboratory rats is largely unknown. Here, ...
2019-10-12Zeitschriftenartikel
Evaluation of Drug Delivery and Efficacy of Ciprofloxacin-Loaded Povidone Foils and Nanofiber Mats in a Wound-Infection Model Based on Ex Vivo Human Skin 
Rancan, Fiorenza; Contardi, Marco; Jurisch, Jana; Blume-Peytavi, Ulrike; Vogt, Annika; Bayer, Ilker S.; Schaudinn, Christoph
Topical treatment of wound infections is often a challenge due to limited drug availability at the site of infection. Topical drug delivery is an attractive option for reducing systemic side effects, provided that a more ...
2019-10-11Zeitschriftenartikel
Optimization of SNAP-25 and VAMP-2 Cleavage by Botulinum Neurotoxin Serotypes A–F Employing Taguchi Design-of-Experiments 
von Berg, Laura; Stern, Daniel; Weisemann, Jasmin; Rummel, Andreas; Dorner, Martin Bernhard; Dorner, Brigitte Gertrud
The detection of catalytically active botulinum neurotoxins (BoNTs) can be achieved by monitoring the enzymatic cleavage of soluble NSF (N-ethylmaleimide-sensitive-factor) attachment protein receptor (SNARE) proteins by ...
2019-09-13Zeitschriftenartikel
Molecular Characterization of Equine Staphylococcus aureus Isolates Exhibiting Reduced Oxacillin Susceptibility 
Scholtzek, Anissa D.; Hanke, Dennis; Walther, Birgit; Eichhorn, Inga; Stöckle, Sabita D.; Klein, Katja-Sophia; Gehlen, Heidrun; Lübke-Becker, Antina; Schwarz, Stefan; Feßler, Andrea T.
The detection of borderline oxacillin-resistant Staphylococcus aureus (BORSA) represents a challenge to both, veterinary and human laboratories. Between 2015 and 2017, 19 equine S. aureus with elevated minimal inhibitory ...
2020-01-16Zeitschriftenartikel
Individual and interpersonal correlates of cardiorespiratory fitness in adults – Findings from the German Health Interview and Examination Survey 
Zeiher, Johannes; Manz, Kristin; Kuntz, Benjamin; Perumal, Nita; Keil, Thomas; Mensink, Gert B. M.; Finger, Jonas D.
Cardiorespiratory fitness (CRF) is an established predictor of adverse health outcomes. The aim of this study is to investigate potential behavioral, interpersonal and socioeconomic correlates of CRF among men and women ...
2019-12-17Zeitschriftenartikel
IS26-Mediated Transfer of blaNDM–1 as the Main Route of Resistance Transmission During a Polyclonal, Multispecies Outbreak in a German Hospital 
Weber, Robert E.; Pietsch, Michael; Frühauf, Andre; Pfeifer, Yvonne; Martin, Maria; Luft, Dirk; Gatermann, Sören; Pfennigwerth, Niels; Kaase, Martin; Werner, Guido; Fuchs, Stephan
One of the most demanding challenges in infection control is the worldwide dissemination of multidrug-resistant (MDR) bacteria in clinical settings. Especially the increasing prevalence of carbapenemase producing Gram-negative ...
2019-08-26Zeitschriftenartikel
Metaproteomics analysis of microbial diversity of human saliva and tongue dorsum in young healthy individuals 
Rabe, Alexander; Salazar, Manuela Gesell; Michalik, Stephan; Fuchs, Stephan; Welk, Alexander; Kocher, Thomas; Völker, Uwe
Background: The human oral microbiome influences initiation or progression of diseases like caries or periodontitis. Metaproteomics approaches enable the simultaneous investigation of microbial and host proteins and their ...
2019-10-16Zeitschriftenartikel
Geographical Variability Affects CCHFV Detection by RT–PCR: A Tool for In-Silico Evaluation of Molecular Assays 
Gruber, Cesare E. M.; Bartolini, Barbara; Castilletti, Concetta; Mirazimi, Ali; Hewson, Roger; Christova, Iva; Avšič, Tatjana; Grunow, Roland; Papa, Anna; Sánchez-Seco, Maria P.; Koopmans, Marion; Ippolito, Giuseppe; Capobianchi, Maria R.; Reusken, Chantal B. E. M.; Antonino, Di Caro
The Crimean–Congo hemorrhagic fever virus (CCHFV) is considered to be a major emerging infectious threat, according to the WHO R&D blueprint. A wide range of CCHFV molecular assays have been developed, employing varied ...
2019-08-30Zeitschriftenartikel
Trends in socioeconomic inequalities in self-rated health in Germany: a time-trend analysis of repeated cross-sectional health surveys between 2003 and 2012 
Wachtler, Benjamin; Hoebel, Jens; Lampert, Thomas
Objectives This study assessed the extent of educational and income inequalities in self-rated health (SRH) in the German adult population between 2003 and 2012 and how these inequalities changed over time. Design ...
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