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Now showing items 2921-2930 of 3394

2020-12-11Zeitschriftenartikel

Population change and the burden of hospitalization in Germany 2000–2040: Decomposition analysis and projection

Nowossadeck, Enno; Prütz, Franziska; Teti, Andrea

Demographic factors, such as population aging and shrinkage, and non-demographic factors, such as hospitalization rate and length of hospital stay, generate challenges for inpatient care. This paper used decomposition ...

2021-01-19Zeitschriftenartikel

Assessment of the Effects of Active Immunisation against Respiratory Syncytial Virus (RSV) using Decision-Analytic Models: A Systematic Review with a Focus on Vaccination Strategies, Modelling Methods and Input Data

Treskova, Marina; Pozo‑Martin, Francisco; Scholz, Stefan; Schönfeld, Viktoria; Wichmann, Ole

Background: Several vaccine and antibody candidates are currently in development for the prevention of lower respiratory tract infections caused by the respiratory syncytial virus (RSV). Methods: We searched MEDLINE, ...

2020-12-16Zeitschriftenartikel

Wie lässt sich die Eliminierung von Hepatitis B, C und D in Deutschland messen? Ergebnisse eines interdisziplinären Arbeitstreffens

Zimmermann, Ruth; Külper-Schiek, Wiebe; Steffen, Gyde; Gillesberg Lassen, Sofie; Bremer, Viviane; Dudareva, Sandra; Hepatitis-Monitoring- Arbeitsgruppe

Hintergrund: Die Weltgesundheitsorganisation (WHO) hat 2016 eine Strategie zur Eliminierung von Hepatitis-B-, -C- und -D-Virusinfektionen verfasst und Indikatoren zum Monitoring des Fortschritts definiert. Das Robert ...

2020-12-31Zeitschriftenartikel

Reflections on key methodological decisions in national burden of disease assessments

von der Lippe, Elena; Devleesschauwer, Brecht; Gourley, Michelle; Haagsma, Juanita; Hilderink, Henk; Porst, Michael; Wengler, Annelene; Wyper, Grant; Grant, Ian

Background: Summary measures of population health are increasingly used in different public health reporting systems for setting priorities for health care and social service delivery and planning. Disability-adjusted ...

2020-12-18Zeitschriftenartikel

Genetic Diversity of the Flavohemoprotein Gene of Giardia lamblia: Evidence for High Allelic Heterozygosity and Copy Number Variation

Saghaug, C. S.; Klotz, Christian; Kallio, J. P.; Aebischer, Toni; Langeland, N.; Hanevik, K.

Purpose: The flavohemoprotein (gFlHb) in Giardia plays an important role in managing nitrosative and oxidative stress, and potentially also in virulence and nitroimidazole drug tolerance. The aim of this study was to analyze ...

2020-12-22Zeitschriftenartikel

Surgical hand preparation in an equine hospital: Comparison of general practice with a standardised protocol and characterisation of the methicillin-resistant Staphylococcus aureus recovered

Rocktäschel, Tina; Renner-Martin, Katharina; Cuny, Christiane; Brehm, Walter; Truyen, Uwe; Speck, Stephanie

Presurgical hand asepsis is part of the daily routine in veterinary medicine. Nevertheless, basic knowledge seems to be low, even among specialised veterinary surgeons. The major objectives of our study were to assess ...

2020-10-09Zeitschriftenartikel

Monoklonale Antikörper zur antiinfektiven Therapie

Klug, Bettina; Schnierle, Barbara; Trebesch, Isabel

Ein Jahrhundert lang wurde die Serumtherapie von Seren tierischen Ursprungs und Hyperimmunglobulinen dominiert. Obwohl seit Ende der Achtzigerjahre des letzten Jahrhunderts zahlreiche monoklonale Antikörper (MAB) insbesondere ...

2021-01-01Zeitschriftenartikel

Heteromultivalent topology-matched nanostructures as potent and broad-spectrum influenza A virus inhibitors

Nie, Chuanxiong; Stadtmüller, Marlena; Parshad, Badri; Wallert, Matthias; Ahmadi, Vahid; Kerkhoff, Yannic; Bhatia, Sumati; Block, Stephan; Cheng, Chong; Wolff, Thorsten; Haag, Rainer

Here, we report the topology-matched design of heteromultivalent nanostructures as potent and broad-spectrum virus entry inhibitors based on the host cell membrane. Initially, we investigate the virus binding dynamics to ...

2021-01-06Zeitschriftenartikel

Excess mortality in adults with documented diabetes in Germany: routine data analysis of all insurance claims in Germany 2013–2014

Schmidt, Christian; Reitzle, Lukas; Heidemann, Christin; Paprott, Rebecca; Ziese, Thomas; Scheidt-Nave, Christa; Baumert, Jens

Objectives: Little is known about the age-specific excess mortality pattern of people with diagnosed diabetes in Germany. Thus, our goal was to determine the excess mortality in diagnosed diabetes overall and stratified ...

2020-12-29Zeitschriftenartikel

Excellent performance of CHROMagarTM LIN-R to selectively screen for linezolid-resistant enterococci and staphylococci

Layer, Franziska; Weber, Robert E.; Fleige, Carola; Strommenger, Birgit; Cuny, Christiane; Werner, Guido

The increasing number of nosocomial pathogens with resistances against last resort antibiotics like linezolid leads to a pressing need for the reliable detection of these drug-resistant bacteria. National guidelines ...

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