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2021-11-16Zeitschriftenartikel
Infektionsrisiko mit SARS-CoV-2 von Beschäftigten in Gesundheitsberufen während der Pandemie 
Ergebnisse einer bundesweiten seroepidemiologischen Studie
Wachtler, Benjamin; Neuhauser, Hannelore; Haller, Sebastian; Grabka, Markus M.; Zinn, Sabine; Schaade, Lars; Hövener, Claudia; Hoebel, Jens
Berufliche Tätigkeiten im Gesundheitswesen erfordern häufig physische Nähe zu anderen Menschen und den direkten Kontakt zu infektiösen Patientinnen und Patienten. Dies kann zu einem höheren Risiko für eine Infektion mit ...
2017-06-15Zeitschriftenartikel
Alcohol consumption among adults in Germany: risky drinking levels 
Lange, Cornelia; Manz, Kristin; Kuntz, Benjamin
Consuming harmful amounts of alcohol is considered a contributing factor in over 200 diseases. Women who drink over 10 g and men who drink more than 20 g of pure alcohol daily are already consuming risky amounts. According ...
2021-11-15Zeitschriftenartikel
Fusaricidins, Polymyxins and Volatiles Produced by Paenibacillus polymyxa Strains DSM 32871 and M1 
Mülner, Pascal; Schwarz, Elisa; Dietel, Kristin; Herfort, Stefanie; Jähne, Jennifer; Lasch, Peter; Cernava, Tomislav; Berg, Gabriele; Vater, Joachim
Paenibacilli are efficient producers of potent agents against bacterial and fungal pathogens, which are of great interest both for therapeutic applications in medicine as well as in agrobiotechnology. Lipopeptides produced ...
2021-05-25Zeitschriftenartikel
Nipah Virus Efficiently Replicates in Human Smooth Muscle Cells without Cytopathic Effect 
DeBuysscher, Blair L.; Scott, Dana P.; Rosenke, Rebecca; Wahl, Victoria; Feldmann, Heinz; Prescott, Joseph
Nipah virus (NiV) is a highly pathogenic zoonotic virus with a broad species tropism, originating in pteropid bats. Human outbreaks of NiV disease occur almost annually, often with high case-fatality rates. The specific ...
2020-09-08Zeitschriftenartikel
Silence as a way of niche adaptation: mecC-MRSA with variations in the accessory gene regulator (agr) functionality express kaleidoscopic phenotypes 
Huber, Charlotte; Stamm, Ivonne; Ziebuhr, Wilma; Marincola, Gabriella; Bischoff, Markus; Strommenger, Birgit; Jaschkowitz, Greta; Marciniak, Tessa; Cuny, Christiane; Witte, Wolfgang; Doellinger, Joerg; Schaudinn, Christoph; Thürmer, Andrea; Epping, Lennard; Semmler, Torsten; Lübke-Becker, Antina; Wieler, Lothar H.; Walther, Birgit
Functionality of the accessory gene regulator (agr) quorum sensing system is an important factor promoting either acute or chronic infections by the notorious opportunistic human and veterinary pathogen Staphylococcus ...
2020-11-12Zeitschriftenartikel
Simplified Bioprinting-Based 3D Cell Culture Infection Models for Virus Detection 
Koban, Robert; Lam, Tobias; Schwarz, Franziska; Kloke, Lutz; Bürge, Silvio; Ellerbrok, Heinz; Neumann, Markus
Studies of virus–host interactions in vitro may be hindered by biological characteristics of conventional monolayer cell cultures that differ from in vivo infection. Three-dimensional (3D) cell cultures show more in vivo-like ...
2021-02-01Zeitschriftenartikel
Interpretable detection of novel human viruses from genome sequencing data 
Bartoszewicz, Jakub M.; Seidel, Anja; Renard, Bernhard Y.
Viruses evolve extremely quickly, so reliable meth- ods for viral host prediction are necessary to safe- guard biosecurity and biosafety alike. Novel human- infecting viruses are difficult to detect with stan- dard ...
2021-02-15Zeitschriftenartikel
Genome-Wide Association Studies for the Detection of Genetic Variants Associated With Daptomycin and Ceftaroline Resistance in Staphylococcus aureus 
Weber, Robert E.; Fuchs, Stephan; Layer, Franziska; Sommer, Anna; Bender, Jennifer K.; Thürmer, Andrea; Werner, Guido; Strommenger, Birgit
Background: As next generation sequencing (NGS) technologies have experienced a rapid development over the last decade, the investigation of the bacterial genetic architecture reveals a high potential to dissect causal ...
2021-01-19Zeitschriftenartikel
Genome-Based Analyses of Fitness Effects and Compensatory Changes Associated with Acquisition of blaCMY-, blaCTX-M-, and blaOXA-48/VIM-1-Containing Plasmids in Escherichia coli 
Pietsch, Michael; Pfeifer, Yvonne; Fuchs, Stephan; Werner, Guido
Background: Resistance plasmids are under selective conditions beneficial for the bacterial host, but in the absence of selective pressure, this carriage may cause fitness costs. Compensation of this fitness burden is ...
2020-10-06Zeitschriftenartikel
Expression of in vivo biotinylated recombinant antigens SAG1 and SAG2A from Toxoplasma gondii for improved seroepidemiological bead-based multiplex assays 
Klein, Sandra; Stern, Daniel; Seeber, Frank
Background Few bead-based multiplex assays have been described that detect antibodies against the protozoan parasite Toxoplasma gondii in large-scale seroepidemiological surveys. Moreover, each multiplex assay has ...
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