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2021-05-21Zeitschriftenartikel
Increasing Number of Individuals Receiving Hepatitis B nucleos(t)ide Analogs Therapy in Germany, 2008–2019 
Maisa, Anna; Kollan, Christian; an der Heiden, Matthias; van Bömmel, Florian; Cornberg, Markus; Mauss, Stefan; Wedemeyer, Heiner; Schmidt, Daniel; Dudareva, Sandra
Background: Germany is a low prevalence country for hepatitis B virus (HBV) infection with higher prevalence in vulnerable groups. The number of treated chronic hepatitis B (CHB) patients is unknown. We aimed to determine ...
2021-05-06Zeitschriftenartikel
Complete Genome Sequences of Three Clinical Listeria monocytogenes Sequence Type 8 Strains from Recent German Listeriosis Outbreaks 
Fischer, Martin A.; Thürmer, Andrea; Flieger, Antje; Halbedel, Sven
We report here the closed genome sequences of three clinical Listeria monocytogenes strains of multilocus sequence typing (MLST) sequence type 8 (ST8). These strains are representatives of three separate listeriosis outbreak ...
2021-05-27Zeitschriftenartikel
Draft Genome Sequence of Environmental Isolate Acinetobacter nosocomialis U20-HoPe-S34-3 from Germany 
Wilharm, Gottfried
The draft genome sequence of Acinetobacter nosocomialis U20-HoPe-S34-3, isolated from soil sampled from the banks of the river Holtemme in Germany, is provided. The strain has an average nucleotide identity of 98.3% to the ...
2021-07-14Zeitschriftenartikel
Virological Surveillance and Molecular Characterization of Human Parainfluenzavirus Infection in Children with Acute Respiratory Illness: Germany, 2015–2019 
Oh, Djin-Ye; Biere, Barbara; Grenz, Markus; Wolff, Thorsten; Schweiger, Brunhilde; Dürrwald, Ralf; Reiche, Janine
Human parainfluenza viruses (HPIVs) are important causes of respiratory illness, especially in young children. However, surveillance for HPIV is rarely performed continuously, and national-level epidemiologic and genetic ...
2021-07-13Zeitschriftenartikel
Mathematical Modelling of the Molecular Mechanisms of Interaction of Tenofovir with Emtricitabine against HIV 
Iannuzzi, Sara; von Kleist, Max
The combination of the two nucleoside reverse transcriptase inhibitors (NRTI) tenofovir disoproxil fumarate (TDF) and emtricitabine (FTC) is used in most highly active antiretroviral therapies for treatment of HIV-1 ...
2021-06-18Zeitschriftenartikel
First Serological Evidence of Crimean-Congo Hemorrhagic Fever Virus and Rift Valley Fever Virus in Ruminants in Tunisia 
Zouaghi, Khaoula; Bouattour, Ali; Aounallah, Hajer; Surtees, Rebecca; Krause, Eva; Michel, Janine; Mamlouk, Aymen; Nitsche, Andreas; M’ghirbi, Youmna
Crimean-Congo hemorrhagic fever virus (CCHFV, Nairoviridae family) and Rift Valley fever virus (RVFV, Phenuiviridae family) are zoonotic vector-borne pathogens with clinical relevance worldwide. Our study aimed to determine ...
2021-03-01Zeitschriftenartikel
The epidemiology of carbapenem resistance in Acinetobacter baumannii complex in Germany (2014–2018): an analysis of data from the national Antimicrobial Resistance Surveillance system 
Said, Dunja; Willrich, Niklas; Ayobami, Olaniyi; Noll, Ines; Eckmanns, Tim; Markwart, Robby
Background Carbapenem-resistant Acinetobacter baumannii complex (CRABC) has globally emerged as a serious public health challenge. This study aimed to describe epidemiological trends and risk factors of carbapenem resistance ...
2021-03-15Zeitschriftenartikel
Redistributing ill-defined causes of death – a case study from the BURDEN 2020-project in Germany 
Wengler, Annelene; Gruhl, Heike; Plaß, Dietrich; Leddin, Janko; Rommel, Alexander; von der Lippe, Elena; the BURDEN 2020 study group
Background The cause of death statistics in Germany include a relatively high share (26% in 2017) of ill-defined deaths (IDD). To make use of the cause of death statistics for Burden of Disease calculations we redistribute ...
2021-08-27Zeitschriftenartikel
Pre-existing health conditions and severe COVID-19 outcomes: an umbrella review approach and meta-analysis of global evidence 
Treskova-Schwarzbach, Marina; Haas, Laura; Reda, Sarah; Pilic, Antonia; Borodova, Anna; Karimi, Kasra; Koch, Judith; Nygren, Teresa; Scholz, Stefan; Schönfeld, Viktoria; Vygen-Bonnet, Sabine; Wichmann, Ole; Harder, Thomas
Background This study applies an umbrella review approach to summarise the global evidence on the risk of severe COVID-19 outcomes in patients with pre-existing health conditions. Methods Systematic reviews (SRs) were ...
2021-08-20Zeitschriftenartikel
Propagation of CJD Prions in Primary Murine Glia Cells Expressing Human PrPc 
Wälzlein, Joo-Hee; Schwenke, Karla A.; Beekes, Michael
There are various existing cell models for the propagation of animal prions. However, in vitro propagation of human prions has been a long-standing challenge. This study presents the establishment of a long-term primary ...
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