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2022-01-20Zeitschriftenartikel
RNA reference materials with defined viral RNA loads of SARS-CoV-2—A useful tool towards a better PCR assay harmonization 
Vierbaum, Laura; Wojtalewicz, Nathalie; Grunert, Hans-Peter; Lindig, Vanessa; Duehring, Ulf; Drosten, Christian; Corman, Victor; Niemeyer, Daniela; Ciesek, Sandra; Rabenau, Holger F.; Berger, Annemarie; Obermeier, Martin; Nitsche, Andreas; Michel, Janine; Mielke, Martin; Huggett, Jim; O’Sullivan, Denise; Busby, Eloise; Cowen, Simon; Vallone, Peter M.; Cleveland, Megan H.; Falak, Samreen; Kummrow, Andreas; Keller, Thomas; Schellenberg, Ingo; Zeichhardt, Heinz; Kammel, Martin
SARS-CoV-2, the cause of COVID-19, requires reliable diagnostic methods to track the circulation of this virus. Following the development of RT-qPCR methods to meet this diagnostic need in January 2020, it became clear ...
2022-02-02Zeitschriftenartikel
Construction and validation of safe Clostridium botulinum Group II surrogate strain producing inactive botulinum neurotoxin type E toxoid 
Nowakowska, Maria B.; Selby, Katja; Przykopanski, Adina; Krüger, Maren; Krez, Nadja; Dorner, Brigitte G.; Dorner, Martin B.; Jin, Rongsheng; Minton, Nigel P.; Rummel, Andreas; Lindström, Miia
Botulinum neurotoxins (BoNTs), produced by the spore-forming bacterium Clostridium botulinum, cause botulism, a rare but fatal illness affecting humans and animals. Despite causing a life-threatening disease, BoNT is a ...
2022-02-02Zeitschriftenartikel
Advanced sequencing approaches detected insertions of viral and human origin in the viral genome of chronic hepatitis E virus patients 
Papp, C.‑Patrick; Biedermann, Paula; Harms, Dominik; Wang, Bo; Kebelmann, Marianne; Choi, Mira; Helmuth, Johannes; Corman, Victor M.; Thürmer, Andrea; Altmann, Britta; Klink, Patrycja; Hofmann, Jörg; Bock, C.‑Thomas
The awareness of hepatitis E virus (HEV) increased significantly in the last decade due to its unexpectedly high prevalence in high-income countries. There, infections with HEV-genotype 3 (HEV-3) are predominant which can ...
2022-01-29Zeitschriftenartikel
Phenotypic Diversity of Cryptococcus neoformans var. neoformans Clinical Isolates from Localized and Disseminated Infections 
Birkenfeld, Zena M.; Dittel, Nikita; Harrer, Thomas; Stephan, Christoph; Kiderlen, Albrecht F.; Rickerts, Volker
Cryptococcus neoformans var. neoformans is the second most prevalent agent of cryptococcosis in central Europe. Infections mostly present with localized skin and disseminated infections. Previous studies did not find these ...
2022-01-22Zeitschriftenartikel
The role of personality traits and social support in relations of health-related behaviours and depressive symptoms 
Edler, Johanna‑Sophie; Manz, Kristin; Rojas‑Perilla, Natalia; Baumeister, Harald; Cohrdes, Caroline
Background: Previous evidence has suggested that physically inactive individuals and extensive media users are at high risk for experiencing depressive symptoms. We examined personality traits and perceived social support ...
2022-01-13Zeitschriftenartikel
Dengue virus infections among European travellers, 2015 to 2019 
Gossner, Céline M.; Fournet, Nelly; Frank, Christina; Fernández-Martínez, Beatriz; Manso, Martina Del; Dias, Joana Gomes; de Valk, Henriette
Background: Dengue is a disease with major impacts on public health in tropical and subtropical countries. In Europe, in the past decade, few autochthonous outbreaks were described. Aim: We aimed to identify factors ...
2021-12-25Zeitschriftenartikel
Glycopeptide resistance in Enterococcus spp. and coagulase-negative staphylococci from hospitalised patients in Germany: occurrence, characteristics and dalbavancin susceptibility 
Kresken, Michael; Klare, Ingo; Wichelhaus, Thomas A.; Wohlfarth, Esther; Layer-Nicolaou, Franziska; Neumann, Bernd; Werner, Guido; Study Group ‘Antimicrobial Resistance’ of the Paul-Ehrlich-Society for Chemotherapy
Objectives: The aim of this study was to evaluate the occurrence of glycopeptide resistance in enterococci and coagulase-negative staphylococci (CoNS) and to determine the susceptibilities of the identified glycopeptide-resistant ...
2021-01-17Zeitschriftenartikel
SARS-CoV-2 prevalence and immunity: a hospital-based study from Malawi 
Meinus, C.; Singer, R.; Nandi, B.; Jagot, O.; Becker-Ziaja, B.; Karo, B.; Mvula, B.; Jansen, A.; Baumann, J.; Schultz, A.
Background: COVID-19 transmission and disease dynamics in sub-Saharan Africa are not well understood. Our study aims to provide insight into COVID-19 epidemiology in Malawi by estimating SARS-CoV-2 prevalence and immunity ...
2022-01-18Zeitschriftenartikel
The interplay between community and hospital Enterococcus faecium clones within health-care settings: a genomic analysis 
van Hal, Sebastiaan J.; Willem, Rob J. L.; Gouliour, Theodore; Ballard, Susan A.; Coqu, Teresa M.; Hammerum, Anette M.; Hegstad, Kristin; Pinholt, Mette; Howden, Benjamin P.; Malhotra-Kumar, Surbhi; Werner, Guido; Yanagihara, Katsunori; Earl, Ashlee M.; Raven, Katherine E.; Corander, Jukka; Bowden, Rory; the Enterococcal Study Group
Background: The genomic relationships among Enterococcus faecium isolates are the subject of ongoing research that seeks to clarify the origins of observed lineages and the extent of horizontal gene transfer between them, ...
2022-01-24Zeitschriftenartikel
SxsA, a novel surface protein mediating cell aggregation and adhesive biofilm formation of Staphylococcus xylosus 
Schiffer, Carolin J.; Schaudinn, Christoph; Ehrmann, Matthias A.; Vogel, Rudi F.
Biofilm formation of staphylococci has been an emerging field of research for many years. However, the underlying molecular mechanisms are still not fully understood and vary widely between species and strains. The aim of ...
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