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2016-12-02Zeitschriftenartikel

Drivers of airborne human-to-human pathogen transmission

Herfst, Sander; Böhringer, Michael; Karo, Basel; Lawrence, Philip; Lewis, Nicola S.; Mina, Michael J.; Russell, Charles J.; Steel, John; Swart, Rik L. de; Menge, Christian

Airborne pathogens - either transmitted via aerosol or droplets - include a wide variety of highly infectious and dangerous microbes such as variola virus, measles virus, influenza A viruses, Mycobacterium tuberculosis, ...

2016-12-09Zeitschriftenartikel

Rapid and sensitive point-of-care detection of Orthopoxviruses by ABICAP immunofiltration

Stern, Daniel; Olson, Victoria A.; Smith, Scott K.; Pietraszczyk, Marko; Miller, Lilija; Miethe, Peter; Dorner, Brigitte; Nitsche, Andreas

Background: The rapid and reliable detection of infectious agents is one of the most challenging tasks in scenarios lacking well-equipped laboratory infrastructure, like diagnostics in rural areas of developing countries. ...

2016-12-08Zeitschriftenartikel

Highly pathogenic avian influenza A(H5N8) outbreaks: protection and management of exposed people in Europe, 2014/15 and 2016

Adlhoch, Cornelia; Brown, I. H.; Angelova, S. G.; Bálint, A.; Bouwstra, R.; Buda, Silke; Castrucci, M. R.; Dabrera, G.; Dán, A.; Grund, C.; Harder, T.; Hoek, W. van der; Krisztalovics, K.; Parry-Ford, F.; Popescu, R.; Wallensten, A.; Zdravkova, A.; Zohari, S.; Tsolova, S.; Penttinen, P.

Introduction of highly pathogenic avian influenza (HPAI) virus A(H5N8) into Europe prompted animal and human health experts to implement protective measures to prevent transmission to humans. We describe the situation in ...

2016-12-12Zeitschriftenartikel

Surveillance von Tuberkulose/HIV – ein Beispiel guter Praxis aus Botswana

Robert Koch-Institut

2015-10-20Zeitschriftenartikel

Background Paper for the update of meningococcal vaccination recommendations in Germany: use of the serogroup B vaccine in persons at increased risk for meningococcal disease

Hellenbrand, Wiebke; Koch, Judith; Harder, Thomas; Bogdan, Christian; Heininger, Ulrich; Tenenbaum, Tobias; Terhardt, Martin; Vogel, Ulrich; Wichmann, Ole; Kries, Rüdiger von

In December 2013 Bexsero® became available in Germany for vaccination against serogroup B meningococci (MenB). In August 2015 the German Standing Committee on Vaccination (STIKO) endorsed a recommendation for use of this ...

2014-03-18Zeitschriftenartikel

Pre- and Post-Processing Workflow for Affinity Purification Mass Spectrometry Data

Fischer, Martina; Zilkenat, Susann; Gerlach, Roman; Wagner, Samuel; Renard, Bernhard Y.

The reliable detection of protein–protein interactions by affinity purification mass spectrometry (AP-MS) is crucial for the understanding of biological processes. Quantitative information can be used to separate truly ...

2015-10-24Zeitschriftenartikel

Prevalence and correlates of DSM-IV-TR major depressive disorder, self-reported diagnosed depression and current depressive symptoms among adults in Germany

Maske, Ulrike E.; Buttery, Amanda K.; Beesdo-Baum, Katja; Riedel-Heller, Steffi; Hapke, Ulfert; Busch, Markus

Background: While standardized diagnostic interviews using established criteria are the gold standard for assessing depression, less time consuming measures of depression and depressive symptoms are commonly used in ...

2016-12-30Zeitschriftenartikel

Adequate immune response ensured by binary IL-2 and graded CD25 expression in a murine transfer model

Fuhrmann, Franziska; Lischke, Timo; Gross, Fridolin; Scheel, Tobias; Bauer, Laura; Kalim, Khalid Wasim; Radbruch, Andreas; Herzel, Hanspeter; Hutloff, Andreas; Baumgrass, Ria

The IL-2/IL-2Ralpha (CD25) axis is of central importance for the interplay of effector and regulatory T cells. Nevertheless, the question how different antigen loads are translated into appropriate IL-2 production to ensure ...

2015-07-31Zeitschriftenartikel

Gesundheitskompetenz von Erwachsenen in Deutschland

Ergebnisse der Studie „Gesundheit in Deutschland aktuell“ (GEDA)

Jordan, Susanne; Hoebel, Jens

Hintergrund: In modernen Informationsgesellschaften wird Gesundheitskompetenz (GK) als wichtige Fähigkeit zur Gesunderhaltung und Krankheitsbewältigung erachtet. Hierfür sind verschiedene kognitive und soziale Fähigkeiten ...

2017-01-04Zeitschriftenartikel

PaPrBaG: A machine learning approach for the detection of novel pathogens from NGS data

Deneke, Carlus; Rentzsch, Robert; Renard, Bernhard Y.

The reliable detection of novel bacterial pathogens from next-generation sequencing data is a key challenge for microbial diagnostics. Current computational tools usually rely on sequence similarity and often fail to detect ...

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