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2017-10-04Zeitschriftenartikel

Structural and immunochemical relatedness suggests a conserved pathogenicity motif for secondary cell wall polysaccharides in Bacillus anthracis and infection-associated Bacillus cereus

Kamal, Nazia; Ganguly, Jhuma; Saile, Elke; Klee, Silke; Hoffmaster, Alex; Carlson, Russell W.; Forsberg, Lennart S.; Kannenberg, Elmar L.; Quinn, Conrad P.

Bacillus anthracis (Ba) and human infection-associated Bacillus cereus (Bc) strains Bc G9241 and Bc 03BB87 have secondary cell wall polysaccharides (SCWPs) comprising an aminoglycosyl trisaccharide repeat: →4)-β-d-ManpNA ...

2017-09-04Zeitschriftenartikel

Cost-effectiveness of human papillomavirus vaccination in Germany

Damm, Oliver; Horn, Johannes; Mikolajczyk, Rafael T.; Kretzschmar, Mirjam E. E.; Kaufmann, Andreas M.; Deleré, Yvonne; Ultsch, Bernhard; Wichmann, Ole; Krämer, Alexander; Greiner, Wolfgang

Background: The aim of this study was to assess the cost-effectiveness of human papillomavirus (HPV) vaccination in addition to the current cervical cancer screening programme in Germany using a dynamic transmission ...

2017-09-05Zeitschriftenartikel

Dual RNA-seq reveals no plastic transcriptional response of the coccidian parasite Eimeria falciformis to host immune defenses

Ehret, Totta; Spork, Simone; Dieterich, Christoph; Lucius, Richard; Heitlinger, Emanuel

Background: Parasites can either respond to differences in immune defenses that exist between individual hosts plastically or, alternatively, follow a genetically canalized (“hard wired”) program of infection. Assuming ...

2017-10-04Zeitschriftenartikel

Implementation of the European health interview survey (EHIS) into the German health update (GEDA)

Lange, Cornelia; Finger, Jonas D.; Allen, Jennifer; Born, Sabine; Hoebel, Jens; Kuhnert, Ronny; Müters, Stephan; Thelen, Jürgen; Schmich, Patrick; Varga, Marike; Lippe, Elena von der; Wetzstein, Matthias; Ziese, Thomas

Background: This methodological paper describes the integration of the ‘European Health Interview Survey wave 2’ (EHIS 2) into the ‘German Health Update’ 2014/2015 (GEDA 2014/2015-EHIS). Methods: GEDA 2014/2015-EHIS ...

2017-10-09Zeitschriftenartikel

Live-attenuated tetravalent dengue vaccines: The needs and challenges of post-licensure evaluation of vaccine safety and effectiveness

Wichmann, Ole; Vannice, Kirsten; Asturias, Edwin J.; Luna, Expedito José de Albuquerque; Longini, Ira; Lopez, Anna Lena; Smith, Peter G.; Tissera, Hasitha; Yoon, In-Kyu; Hombach, Joachim

Since December 2015, the first dengue vaccine has been licensed in several Asian and Latin American countries for protection against disease from all four dengue virus serotypes. While the vaccine demonstrated an overall ...

2017-09-21Zeitschriftenartikel

Low antibody prevalence against Bacillus cereus biovar anthracis in Taï National Park, Côte d'Ivoire, indicates high rate of lethal infections in wildlife

Zimmermann, Fee; Köhler, Susanne M.; Nowak, Kathrin; Dupke, Susann; Barduhn, Anne; Düx, Ariane; Lang, Alexander; Nys, Hélène M. De; Gogarten, Jan F.; Grunow, Roland; Couacy-Hymann, Emmanuel; Wittig, Roman M.; Klee, Silke; Leendertz, Fabian H.

Bacillus cereus biovar anthracis (Bcbva) is a member of the B. cereus group which carries both B. anthracis virulence plasmids, causes anthrax-like disease in various wildlife species and was described in several sub-Saharan ...

2017-11-15Zeitschriftenartikel

Indigenous house mice dominate small mammal communities in northern Afghan military bases

Gertler, Christoph; Schlegel, Mathias; Linnenbrink, Miriam; Hutterer, Rainer; König, Patricia; Ehlers, Bernhard; Fischer, Kerstin; Ryll, René; Lewitzki, Jens; Sauer, Sabine; Baumann, Kathrin; Breithaupt, Angele; Faulde, Michael; Teifke, Jens P.; Tautz, Diethard; Ulrich, Rainer G.

Background: Small mammals are important reservoirs for pathogens in military conflicts and peacekeeping operations all over the world. This study investigates the rodent communities in three military bases in Northern ...

2017-10-24Zeitschriftenartikel

Comparative Genomic Analysis of Globally Dominant ST131 Clone with Other Epidemiologically Successful Extraintestinal Pathogenic Escherichia coli (ExPEC) Lineages

Shaik, Sabiha; Ranjan, Amit; Tiwari, Sumeet K.; Hussain, Arif; Nandanwar, Nishant; Kumar, Narender; Jadhav, Savita; Semmler, Torsten; Baddam, Ramani; Islam, Mohammed Aminul; Alam, Munirul; Wieler, Lothar H.; Watanabe, Haruo; Ahmed, Niyaz

Escherichia coli sequence type 131 (ST131), a pandemic clone responsible for the high incidence of extraintestinal pathogenic E. coli (ExPEC) infections, has been known widely for its contribution to the worldwide dissemination ...

2016-12-21Zeitschriftenartikel

Regionale Unterschiede in der Prävalenz von kardiovaskulären Risikofaktoren bei Männern und Frauen in Deutschland

Diederichs, Claudia; Neuhauser, Hannelore; Kroll, Lars Eric; Lange, Cornelia; Mensink, Gert; Dornquast, Christina; Heidemann, Christin; Scheidt-Nave, Christa; Busch, Markus

Hintergrund: Über die Hälfte aller kardiovaskulären Erkrankungen wird von acht zum Teil vermeidbaren Risikofaktoren verursacht. Ziele: Angesichts deutlicher Prävalenz- und Mortalitätsunterschiede bei Herz-Kreislau ...

2017-10-09Zeitschriftenartikel

Analysing published global Ebola Virus Disease research using social network analysis

Hagel, Christiane; Weidemann, Felix; Gauch, Stephan; Edwards, Suzanne; Tinnemann, Peter

Introduction: The 2014/2015 West African Ebola Virus Disease (EVD) outbreak attracted global attention. Numerous opinions claimed that the global response was impaired, in part because, the EVD research was neglected, ...

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