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2018-01-31Zeitschriftenartikel

Disseminating Metaproteomic Informatics Capabilities and Knowledge Using the Galaxy-P Framework

Blank, Clemens; Easterly, Caleb; Gruening, Bjoern; Johnson, James; Kolmeder, Carolin A.; Kumar, Praveen; May, Damon; Mehta, Subina; Mesuere, Bart; Brown, Zachary; Elias, Joshua E.; Hervey, W. Judson; McGowan, Thomas; Muth, Thilo; Nunn, Brook L.; Rudney, Joel; Tanca, Alessandro; Griffin, Timothy J.; Jagtap, Pratik D.

The impact of microbial communities, also known as the microbiome, on human health and the environment is receiving increased attention. Studying translated gene products (proteins) and comparing metaproteomic profiles may ...

2018-01-19Zeitschriftenartikel

Dietary Acid Load and Potassium Intake Associate with Blood Pressure and Hypertension Prevalence in a Representative Sample of the German Adult Population

Krupp, Danika; Esche, Jonas; Mensink, Gert; Klenow, Stefanie; Thamm, Michael; Remer, Thomas

Diets rich in fruits and vegetables, like the Dietary Approaches to Stop Hypertension (DASH)-diet, are usually characterized by high potassium intake and reduced dietary acid load, and have been shown to reduce blood ...

2018-01-04Zeitschriftenartikel

Mixing modes in a population-based interview survey: comparison of a sequential and a concurrent mixed-mode design for public health research

Mauz, Elvira; Lippe, Elena von der; Allen, Jennifer; Schilling, Ralph; Müters, Stephan; Hoebel, Jens; Schmich, Patrick; Wetzstein, Matthias; Kamtsiuris, Panagiotis; Lange, Cornelia

Background: Population-based surveys currently face the problem of decreasing response rates. Mixed-mode designs are now being implemented more often to account for this, to improve sample composition and to reduce ...

2018-01-30Zeitschriftenartikel

Structure of tick-borne encephalitis virus and its neutralization by a monoclonal antibody

Füzik, Tibor; Formanová, Petra; Růžek, Daniel; Yoshii, Kentaro; Niedrig, Matthias; Plevka, Pavel

Tick-borne encephalitis virus (TBEV) causes 13,000 cases of human meningitis and encephalitis annually. However, the structure of the TBEV virion and its interactions with antibodies are unknown. Here, we present cryo-EM ...

2018-01-14Zeitschriftenartikel

Genetic variants of interferon regulatory factor 5 associated with chronic hepatitis B infection

Sy, Bui Tien; Hoan, Nghiem Xuan; Tong, Hoang Van; Meyer, Christian G.; Toan, Nguyen Linh; Song, Le Huu; Bock, Thomas; Velavan, Thirumalaisamy P.

Aim: To investigate possible effects of IRF5 polymorphisms in the 3’ UTR region of the IFR5 locus on susceptibility to hepatitis B virus (HBV) infection and progression of liver diseases among clinically classified ...

2018-01-30Zeitschriftenartikel

Extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli and Acinetobacter baumannii among horses entering a veterinary teaching hospital: The contemporary "Trojan Horse"

Walther, Birgit; Klein, Katja-Sophia; Barton, Ann-Kristin; Semmler, Torsten; Huber, Charlotte; Wolf, Silver Anthony; Tedin, Karsten; Merle, Roswitha; Mitrach, Franziska; Guenther, Sebastian; Lübke-Becker, Antina; Gehlen, Heidrun

Pathogens frequently associated with multi-drug resistant (MDR) phenotypes, including extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae (ESBL-E) and Acinetobacter baumannii isolated from horses admitted ...

2018-02-09Zeitschriftenartikel

Clinically Relevant ESBL-Producing K. pneumoniae ST307 and E. coli ST38 in an Urban West African Rat Population

Schaufler, Katharina; Nowak, Kathrin; Düx, Ariane; Semmler, Torsten; Villa, Laura; Kourouma, Laye; Bangoura, Karim; Wieler, Lothar H.; Leendertz, Fabian H.; Guenther, Sebastian

High-risk ESBL-producing Enterobacteriaceae (ESBL-E) have been described in wild birds and rodents worldwide. Rats are of special interest not only due to their indicator role for environmental pollution with multi-resistant ...

2017-12-20Zeitschriftenartikel

Salon zur Institutsgeschichte: Das besondere Stück. 28.01.2016 bis 15.12.2016

Heldt, Katharina; Senst, Henriette; Riedel, Jessica

Das Robert Koch-Institut (RKI) feierte im Jahr 2016 den 125. Jahrestag seiner Gründung. Die Bibliothek trug durch eine Reihe von Aktivitäten zur Gestaltung des Jubiläumsjahres bei. Unter anderem wurde in der Bibliothek die ...

2017-11-18Zeitschriftenartikel

Legislation of direct-to-consumer genetic testing in Europe: a fragmented regulatory landscape

Kalokairinou, L.; Howard, H. C.; Slokenberga, S.; Fisher, Eva; Flatscher-Thöni, M.; Hartlev, M.; Hellemondt, R. van; Juškevičius, J.; Kapelenska-Pregowska, J.; Kováč, P.; Lovrečić, L.; Nys, Helene de; Paor, A. de; Phillips, A.; Prudil, L.; Rial-Sebbag, E.; Casabona, C. M. Romeo; Sándor, J.; Schuster, A.; Soini, S.; Søvig, K. H.; Stoffel, D.; Titma, T.; Trokanas, T.; Borry, P.

Despite the increasing availability of direct-to-consumer (DTC) genetic testing, it is currently unclear how such services are regulated in Europe, due to the lack of EU or national legislation specifically addressing this ...

2018-02-27Zeitschriftenartikel

Erfassung inzidenter kardiovaskulärer und metabolischer Erkrankungen in epidemiologischen Kohortenstudien in Deutschland

Herrmann, Wolfram J.; Weikert, Cornelia; Bergmann, Manuela; Boeing, Heiner; Katzke, Verena A.; Kaaks, Rudolf; Tiller, Daniel; Greiser, Karin Halina; Heier, Margit; Meisinger, Christa; Schmidt, Carsten Oliver; Neuhauser, Hannelore; Heidemann, Christin; Jünger, Claus; Wild, Philipp S.; Schramm, Sara Helena; Jöckel, Karl-Heinz; Dörr, Marcus; Pischon, Tobias

Hintergrund: Kardiovaskuläre und metabolische Erkrankungen sind häufige Ursachen für Mortalität und Verlust von Lebensqualität in der deutschen Bevölkerung. Zur Erforschung von Risikofaktoren sind populationsbasierte ...

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