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2023-05-12ZeitschriftenartikelCombination of whole genome sequencing and supervised machine learning provides unambiguous identification of eae-positive Shiga toxin-producing Escherichia coli Introduction: The objective of this study was to develop, using a genome wide machine learning approach, an unambiguous model to predict the presence of highly pathogenic STEC in E. coli reads assemblies derived from complex ...
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2023-04-06ZeitschriftenartikelEffect of risk status for severe COVID-19 on individual contact behaviour during the SARS-CoV-2 pandemic in 2020/2021—an analysis based on the German COVIMOD study Background: One of the primary aims of contact restriction measures during the SARS-CoV-2 pandemic has been to protect people at increased risk of severe disease from the virus. Knowledge about the uptake of contact ...
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2023-02-13ZeitschriftenartikelAdvances towards the complete in vitro life cycle of Toxoplasma gondii The full life cycle of Toxoplasma gondii cannot be recapitulated in vitro, and access to certain stages, such as mature tissue cysts (bradyzoites) and oocysts (sporozoites), traditionally requires animal experiments. This ...
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2023-04-26ZeitschriftenartikelTaking hospital pathogen surveillance to the next level High-throughput bacterial genomic sequencing and subsequent analyses can produce large volumes of high-quality data rapidly. Advances in sequencing technology, with commensurate developments in bioinformatics, have increased ...
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2023-04-28ZeitschriftenartikelResults of the first German external quality assessment scheme for the detection of monkeypox virus DNA Background: In May 2022, the monkeypox virus (MPXV) spread into non-endemic countries and the global community was quick to test the lessons learned from the SARS-CoV-2 pandemic. Due to its symptomatic resemblance to ...
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2023-07-25ZeitschriftenartikelEvidence for positive long- and short-term effects of vaccinations against COVID-19 in wearable sensor metrics Vaccines are among the most powerful tools to combat the COVID-19 pandemic. They are highly effective against infection and substantially reduce the risk of severe disease, hospitalization, ICU admission, and death. However, ...
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2023-09-25ZeitschriftenartikelReflections from the COVID-19 pandemic in Germany: lessons for global health
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2023-05-06ZeitschriftenartikelIn Vitro Activity of Cefiderocol against Clinical Gram-Negative Isolates Originating from Germany in 2016/17 Antimicrobial resistance poses a global threat to public health. Of great concern are Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacterales with resistance to carbapenems or third-generation cephalosporins. ...
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2023-04-11ZeitschriftenartikelCollaborative nowcasting of COVID-19 hospitalization incidences in Germany Real-time surveillance is a crucial element in the response to infectious disease outbreaks. However, the interpretation of incidence data is often hampered by delays occurring at various stages of data gathering and ...
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2023-06-20ZeitschriftenartikelRisk Factors for Hepatitis E Virus Infection and Eating Habits in Kidney Transplant Recipients There is a significant risk for ongoing and treatment-resistant courses of hepatitis E virus (HEV) infection in patients after solid organ transplantation. The aim of this study was to identify risk factors for the development ...
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2023-02-24ZeitschriftenartikelAuthor Correction: Short- and long-range interactions in the HIV-1 5′ UTR regulate genome dimerization and packaging
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2023-07-19ZeitschriftenartikelBerufsbedingte Unterschiede bei COVID-19-Morbidität und -Mortalität in Deutschland. Eine Analyse von Krankenkassendaten von 3,17 Mio. Versicherten Einleitung: Dem Beruf wurde während der COVID-19-Pandemie eine zentrale Rolle beim Infektions- und Krankheitsgeschehen zugesprochen. Für Deutschland liegen jedoch bisher nur wenige Auswertungen zu berufsbedingten ...
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2022-12-29ZeitschriftenartikelInnovative Methods Used in Monitoring COVID-19 in Europe: A Multinational Study Several innovative methods have been deployed worldwide to curb the COVID-19 pandemic. The aim of the study is to investigate which innovative methods are used to monitor COVID-19 health issues in Europe and related ...
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2023-09-07ZeitschriftenartikelMental Health Surveillance in Deutschland Mit der Etablierung der psychischen Gesundheit als Public-Health-Thema wird auch ihre Surveillance (Überwachung) gefordert. Am Robert Koch-Institut ist daher eine Mental Health Surveillance für Deutschland im Aufbau. Die ...
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2021-07-02ZeitschriftenartikelThe increasing significance of disease severity in a burden of disease framework Recent estimates have reiterated that non-fatal causes of disease, such as low back pain, headaches and depressive disorders, are amongst the leading causes of disability-adjusted life years (DALYs). For these causes, the ...
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2023-11-13ZeitschriftenartikelModel-based predictions of protective HIV pre-exposure prophylaxis adherence levels in cisgender women Most human immunodeficiency virus (HIV) infections occur in cisgender women in resource-limited settings. In women, self-protection with emtricitabine/tenofovir disoproxil fumarate pre-exposure prophylaxis (FTC/TDF-PrEP) ...
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2023-11-09ZeitschriftenartikelGlobal variation in diabetes diagnosis and prevalence based on fasting glucose and hemoglobin A1c Fasting plasma glucose (FPG) and hemoglobin A1c (HbA1c) are both used to diagnose diabetes, but these measurements can identify different people as having diabetes. We used data from 117 population-based studies and ...
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2023-11-20ZeitschriftenartikelAssociation between the starting age of non-parental Early Childhood Education and Care (ECEC), and psycho-social problems in adolescence in West and East Germany – a natural experiment using data from the German Health Interview and Examination Survey for Children and Adolescents (KiGGS) Introduction: The study aimed to investigate the association between the start age of non-parental Early Childhood Education and Care (ECEC) and psycho-social problems in adolescence. The similarities and differences ...
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2023-09-04ZeitschriftenartikelDeveloping and testing a protocol using a common data model for federated collection and analysis of national perinatal health indicators in Europe [version 2; peer review: 2 approved]Context: International comparisons of the health of mothers and babies provide essential benchmarks for guiding health practice and policy, but statistics are not routinely compiled in a comparable way. These data are ...
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2023-06-02ZeitschriftenartikelDie Bedeutung der Konzepte One Health und Planetary Health für die Umweltmedizin im 21. Jahrhundert Im 21. Jahrhundert führt eine Anhäufung komplexer Krisen wie Klimawandel, Biodiversitätsverlust, Umweltverschmutzungen, Kriege und Pandemien zu ökonomischen, sozialen und gesundheitlichen Problemen für Menschen jetziger ...