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2009-09-03Zeitschriftenartikel DOI: 10.1371/journal.pone.0006883
Cowpox Virus Outbreak in Banded Mongooses (Mungos mungo) and Jaguarundis (Herpailurus yagouaroundi) with a Time-Delayed Infection to Humans
dc.contributor.authorKurth, Andreas
dc.contributor.authorStraube, Martin
dc.contributor.authorKuczka, Annette
dc.contributor.authorDunsche, Anton Josef
dc.contributor.authorMeyer, Hermann
dc.contributor.authorNitsche, Andreas
dc.date.accessioned2018-05-07T13:17:42Z
dc.date.available2018-05-07T13:17:42Z
dc.date.created2009-09-09
dc.date.issued2009-09-03none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/reztfel9uYmxg/PDF/27easAyGdXlKA.pdf
dc.identifier.urihttp://edoc.rki.de/176904/450
dc.description.abstractBackground: Often described as an extremely rare zoonosis, cowpox virus (CPXV) infections are on the increase in Germany. CPXV is rodent-borne with a broad host range and contains the largest and most complete genome of all poxviruses, including parts with high homology to variola virus (smallpox). So far, most CPXV cases have occurred individually in unvaccinated animals and humans and were caused by genetically distinguishable virus strains. Methodology/Principal Findings: Generalized CPXV infections in banded mongooses (Mungos mungo) and jaguarundis (Herpailurus yagouaroundi) at a Zoological Garden were observed with a prevalence of the affected animal group of 100% and a mortality of 30%. A subsequent serological investigation of other exotic animal species provided evidence of subclinical cases before the onset of the outbreak. Moreover, a time-delayed human cowpox virus infection caused by the identical virus strain occurred in a different geographical area indicating that handling/feeding food rats might be the common source of infection. Conclusions/Significance: Reports on the increased zoonotic transmission of orthopoxviruses have renewed interest in understanding interactions between these viruses and their hosts. The list of animals known to be susceptible to CPXV is still growing. Thus, the likely existence of unknown CPXV hosts and their distribution may present a risk for other exotic animals but also for the general public, as was shown in this outbreak. Animal breeders and suppliers of food rats represent potential multipliers and distributors of CPXV, in the context of increasingly pan-European trading. Taking the cessation of vaccination against smallpox into account, this situation contributes to the increased incidence of CPXV infections in man, particularly in younger age groups, with more complicated courses of clinical infections.eng
dc.language.isoeng
dc.publisherRobert Koch-Institut, Biologische Sicherheit
dc.subjectHumanseng
dc.subjectPhylogenyeng
dc.subjectFemaleeng
dc.subjectPolymerase Chain Reactioneng
dc.subjectDisease Outbreakseng
dc.subjectMaleeng
dc.subjectAnimalseng
dc.subjectMicroscopyeng
dc.subjectTime Factorseng
dc.subjectCowpox/transmissioneng
dc.subjectZoonoses/epidemiologyeng
dc.subjectZoonoses/transmissioneng
dc.subjectRiskeng
dc.subjectElectroneng
dc.subjectRatseng
dc.subjectCowpox/epidemiologyeng
dc.subjectCowpox virus/metabolismeng
dc.subjectFelidaeeng
dc.subjectHerpestidaeeng
dc.subject.ddc610 Medizin
dc.titleCowpox Virus Outbreak in Banded Mongooses (Mungos mungo) and Jaguarundis (Herpailurus yagouaroundi) with a Time-Delayed Infection to Humans
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-1001565
dc.identifier.doi10.1371/journal.pone.0006883
dc.identifier.doihttp://dx.doi.org/10.25646/375
local.edoc.container-titlePLoS One
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://www.plosone.org/
local.edoc.container-publisher-namePublic Library of Science
local.edoc.container-volume4
local.edoc.container-issue9
local.edoc.container-year2009

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