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2007-12-03Zeitschriftenartikel DOI: 10.1186/1752-1947-1-165
Therapy-refractory Panton Valentine Leukocidin-positive community-acquired methicillin-sensitive Staphylococcus aureus sepsis with progressive metastatic soft tissue infection: a case report
dc.contributor.authorSchefold, Joerg C
dc.contributor.authorEsposito, Fabrizio
dc.contributor.authorStorm, Christian
dc.contributor.authorHeuck, Dagmar
dc.contributor.authorKrüger, Anne
dc.contributor.authorJörres, Achim
dc.contributor.authorWitte, Wolfgang
dc.contributor.authorHasper, Dietrich
dc.date.accessioned2018-05-07T13:18:15Z
dc.date.available2018-05-07T13:18:15Z
dc.date.created2009-09-17
dc.date.issued2007-12-03none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/reTtUUmvjyEA/PDF/24N3azcJNi3OE.pdf
dc.identifier.urihttp://edoc.rki.de/176904/453
dc.description.abstractWe report a case of fulminant multiple organ failure including the Acute Respiratory Distress Syndrome (ARDS), haemodynamic, and renal failure due to community-acquired methicillin-sensitive Panton Valentine Leukocidin (PVL) positive spa-type 284 (ST121) Staphylococcus aureus septic shock. The patient's first clinical symptom was necrotizing pneumonia. Despite organism-sensitive triple antibiotic therapy with linezolid, imipenem and clindamycin from the first day of treatment, progressive abscess formation in multiple skeletal muscles was observed. As a result, repeated surgical interventions became necessary. Due to progressive soft tissue infection, the anti-microbial therapy was changed to a combination of clindamycin and daptomycin. Continued surgical and antimicrobial therapy finally led to a stabilisation of the patients' condition. The clinical course of our patient underlines the existence of a "PVL-syndrome" which is independent of in vitro Staphylococcus aureus susceptibility. The PVL-syndrome should not only be considered in patients with soft tissue or bone infection, but also in patients with pneumonia. Such a condition, which may easily be mistaken for uncomplicated pneumonia, should be treated early, aggressively and over a long period of time in order to avoid relapsing infection.eng
dc.language.isoeng
dc.publisherRobert Koch-Institut, Infektionskrankheiten / Erreger
dc.subject.ddc610 Medizin
dc.titleTherapy-refractory Panton Valentine Leukocidin-positive community-acquired methicillin-sensitive Staphylococcus aureus sepsis with progressive metastatic soft tissue infection: a case report
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-1001599
dc.identifier.doi10.1186/1752-1947-1-165
dc.identifier.doihttp://dx.doi.org/10.25646/378
local.edoc.container-titleJournal of Medical Case Reports
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://jmedicalcasereports.com/jmedicalcasereports/article/view/5614/1229
local.edoc.container-publisher-nameBioMedCentral
local.edoc.container-volume1
local.edoc.container-issue165
local.edoc.container-year2007

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