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2009-11-12Zeitschriftenartikel DOI: 10.25646/411
Clostridium difficile ribotypes 001, 017, and 027 are associated with lethal C. difficile infection in Hesse, Germany
dc.contributor.authorArvand, M.
dc.contributor.authorHauri, Anja M.
dc.contributor.authorZaiß, Henning
dc.contributor.authorWitte, Wolfgang
dc.contributor.authorBettge-Weller, G.
dc.date.accessioned2018-05-07T13:24:22Z
dc.date.available2018-05-07T13:24:22Z
dc.date.created2009-11-30
dc.date.issued2009-11-12none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/reR76IxolwXg/PDF/27Q5qZFMvExLw.pdf
dc.identifier.urihttp://edoc.rki.de/176904/486
dc.description.abstractFrom January 2008 to April 2009, 72 cases of severe Clostridium difficile infection were reported from 18 different districts in the state of Hesse, Germany. A total of 41 C. difficile isolates from 41 patients were subjected to PCR ribotyping. PCR ribotype (RT) 027 was the most prevalent strain accounting for 24 of 41 (59%) of typed isolates, followed by RT 001 (eight isolates, 20%), RT 017 and 042 (two isolates each), and RT 003, 066, 078, 081, and RKI-034 (one isolate each). Eighteen patients had died within 30 days after admission. C. difficile was reported as underlying cause of or contributing to death in 14 patients, indicating a case fatality rate of 19%. The patients with lethal outcome attributable to C. difficile were 59-89 years-old (median 78 years). Ribotyping results were available for seven isolates associated with lethal outcome, which were identified as RT 027 in three and as RT 001 and 017 in two cases each. Our data suggest that C. difficile RT 027 is prevalent in some hospitals in Hesse and that, in addition to the possibly more virulent RT 027, other toxigenic C. difficile strains like RT 001 and 017 are associated with lethal C. difficile infections in this region.eng
dc.language.isoeng
dc.publisherRobert Koch-Institut, Infektionskrankheiten / Erreger
dc.subjectAdulteng
dc.subject80 and overeng
dc.subjectHumanseng
dc.subjectFemaleeng
dc.subjectPolymerase Chain Reactioneng
dc.subjectDisease Outbreakseng
dc.subjectGermany/epidemiologyeng
dc.subjectVirulenceeng
dc.subjectMaleeng
dc.subjectMiddle Agedeng
dc.subjectIncidenceeng
dc.subjectPopulation Surveillanceeng
dc.subjectClostridium difficile/classificationeng
dc.subjectClostridium difficile/isolation & purificationeng
dc.subjectEnterocolitiseng
dc.subjectRibotypingeng
dc.subjectAgedeng
dc.subjectPseudomembranous/microbiologyeng
dc.subjectCross Infection/microbiologyeng
dc.subjectCross Infection/epidemiologyeng
dc.subjectMandatory Reportingeng
dc.subjectBacterial Toxins/analysiseng
dc.subjectClostridium difficile/pathogenicityeng
dc.subjectPseudomembranous/mortalityeng
dc.subjectEnterotoxins/analysiseng
dc.subjectFeces/microbiologyeng
dc.subjectMegacoloneng
dc.subjectToxic/microbiologyeng
dc.subjectToxic/mortalityeng
dc.subjectToxic/surgeryeng
dc.subject.ddc610 Medizin
dc.titleClostridium difficile ribotypes 001, 017, and 027 are associated with lethal C. difficile infection in Hesse, Germany
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-1003001
dc.identifier.doihttp://dx.doi.org/10.25646/411
local.edoc.container-titleEuroSurveillance
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=19403
local.edoc.container-publisher-nameInstitut de Veille Sanitaire
local.edoc.container-volume14
local.edoc.container-issue45
local.edoc.container-year2009

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