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2009-11-19Zeitschriftenartikel DOI: 10.25646/435
Oseltamivir-resistant influenza A(H1N1) viruses detected in Europe during season 2007-8 had epidemiologic and clinical characteristics similar to co-circulating susceptible A(H1N1) viruses
dc.contributor.authorCiancio, B. C.
dc.contributor.authorMeerhoff, T. J.
dc.contributor.authorKramarz, P.
dc.contributor.authorBonmarin, I.
dc.contributor.authorBorgen, K.
dc.contributor.authorBoucher, C. A.
dc.contributor.authorBuchholz, Udo
dc.contributor.authorBuda, Silke
dc.contributor.authorDijkstra, F.
dc.contributor.authorDudman, S.
dc.contributor.authorDuwe, Susanne
dc.contributor.authorHauge, S. H.
dc.contributor.authorHungnes, Olav
dc.contributor.authorMeijer, Adam
dc.contributor.authorMossong, J.
dc.contributor.authorPaget, W. J.
dc.contributor.authorPhin, N.
dc.contributor.authorSande, M. van der
dc.contributor.authorSchweiger, Brunhilde
dc.contributor.authorNicoll, A.
dc.date.accessioned2018-05-07T13:28:47Z
dc.date.available2018-05-07T13:28:47Z
dc.date.created2009-12-10
dc.date.issued2009-11-19none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/rerPT64WFHUoo/PDF/20atE754RteuI.pdf
dc.identifier.urihttp://edoc.rki.de/176904/510
dc.description.abstractDuring the 2007-08 influenza season, high levels of oseltamivir resistance were detected among influenza A(H1N1) viruses in a number of European countries. We used surveillance data to describe influenza A(H1N1) cases for whom antiviral resistance testing was performed. We pooled data from national studies to identify possible risk factors for infection with a resistant virus and to ascertain whether such infections led to influenza illness of different severity. Information on demographic and clinical variables was obtained from patients or their physicians. Odds ratios for infection with an oseltamivir resistant virus and relative risks for developing certain clinical outcomes were computed and adjusted through multivariable analysis. Overall, 727 (24.3%) of 2,992 tested influenza A(H1N1) viruses from 22 of 30 European countries were oseltamivir-resistant. Levels of resistance ranged from 1% in Italy to 67% in Norway. Five countries provided detailed case-based data on 373 oseltamivir resistant and 796 susceptible cases. By multivariable analysis, none of the analysed factors was significantly associated with an increased risk of infection with an oseltamivir-resistant virus. Similarly, infection with an oseltamivir-resistant virus was not significantly associated with a different risk of pneumonia, hospitalisation or any clinical complication. The large-scale emergence of oseltamivir-resistant viruses in Europe calls for a review of guidelines for influenza treatment.eng
dc.language.isoeng
dc.publisherRobert Koch-Institut, Infektionsepidemiologie
dc.subjectAdolescenteng
dc.subjectPreschooleng
dc.subjectNewborneng
dc.subjectHuman/epidemiologyeng
dc.subjectHumanseng
dc.subjectFemaleeng
dc.subjectDisease Outbreakseng
dc.subjectMaleeng
dc.subjectMiddle Agedeng
dc.subjectRisk Factorseng
dc.subjectChildeng
dc.subjectAdulteng
dc.subjectCase-Control Studieseng
dc.subjectCohort Studieseng
dc.subjectQuestionnaireseng
dc.subjectAgedeng
dc.subjectEurope/epidemiologyeng
dc.subjectInfanteng
dc.subjectRetrospective Studieseng
dc.subjectOdds Ratioeng
dc.subjectDrug Resistanceeng
dc.subjectInfluenza A Viruseng
dc.subjectH1N1 Subtype/classificationeng
dc.subjectH1N1 Subtype/drug effectseng
dc.subjectH1N1 Subtype/geneticseng
dc.subjectInfluenzaeng
dc.subjectHuman/virologyeng
dc.subjectSeasonseng
dc.subjectTreatment Outcomeeng
dc.subjectRiskeng
dc.subjectYoung Adulteng
dc.subjectAntiviral Agents/pharmacologyeng
dc.subjectViral*/geneticseng
dc.subjectOseltamivir/pharmacology*eng
dc.subjectPractice Guidelines as Topiceng
dc.subject.ddc610 Medizin
dc.titleOseltamivir-resistant influenza A(H1N1) viruses detected in Europe during season 2007-8 had epidemiologic and clinical characteristics similar to co-circulating susceptible A(H1N1) viruses
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-1003329
dc.identifier.doihttp://dx.doi.org/10.25646/435
local.edoc.container-titleEuroSurveillance
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=19412
local.edoc.container-publisher-nameInstitut de Veille Sanitaire
local.edoc.container-volume14
local.edoc.container-issue46
local.edoc.container-year2009

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