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2018-08-06Zeitschriftenartikel DOI: 10.25646/5661
The usefulness of C-reactive protein in predicting malaria parasitemia in a sub-Saharan African region
dc.contributor.authorSarfo, Bismark Osei
dc.contributor.authorHahn, Andreas
dc.contributor.authorSchwarz, Norbert Georg
dc.contributor.authorJaeger, Anna
dc.contributor.authorSarpong, Nimako
dc.contributor.authorMarks, Florian
dc.contributor.authorAdu-Sarkodie, Yaw
dc.contributor.authorTamminga, Thalea
dc.contributor.authorMay, Juergen
dc.date.accessioned2018-09-11T06:37:46Z
dc.date.available2018-09-11T06:37:46Z
dc.date.issued2018-08-06none
dc.identifier.other10.1371/journal.pone.0201693
dc.identifier.urihttp://edoc.rki.de/176904/5726
dc.description.abstractBackground: Malaria remains a leading cause of childhood mortality in sub-Saharan Africa. Identifying patients who are at risk for severe manifestations at presentation still remains challenging. This study examines whether a semi-quantitative test on C-Reactive Protein (CRP) could be useful for rapidly predicting the presence or absence of malarial parasitemia in febrile children. Method: Data were collected from children with fever or a history of fever at the Agogo Presbyterian Hospital in the Ashanti Region of Ghana. Haematological measurements, microscopic detection of plasmodium species and semi-quantitative CRP measurements with a membrane–based immunoassay for whole blood were performed. CRP was classified as positive when the measured level was ≥ 10 mg/l. Results: During 548 visits, thick blood film results could be obtained from 541 patients, 270 (49.3%) yielded parasitemia with Plasmodium spp. Whereas malaria parasites were detected in only a few patients (7.1%) with normal CRP levels (< 10mg/l), more than a half of patients with an increased CRP concentration (≥ 10 mg/l) were parasite positive (OR 14.5 [CI 4.4–47.6], p<0.001). Patients with increased CRP levels had more than an eight-fold likelihood for parasitemia after correction for other parameters (adjusted OR 8.7 [CI 2.5–30.5], p<0.001). Sensitivity, specificity as well as positive predictive and negative predictive values of CRP for malaria were 99.3% (CI 96.2%-100%), 9.2% (CI 6.4%-12.8%), 31.7% (CI 27.4%-36.1%) and 97.0% (CI 84.2%-99.9%), respectively. Conclusion: The semi-quantitative method of measuring CRP is cheap, rapid and easy to perform but not useful in predicting parasitemia and malaria. However, due to its high negative predictive value, it could have a role in identifying those patients unlikely to be presenting with clinical malaria.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleThe usefulness of C-reactive protein in predicting malaria parasitemia in a sub-Saharan African regionnone
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:0257-176904/5726-8
dc.identifier.doihttp://dx.doi.org/10.25646/5661
dc.type.versionpublishedVersionnone
local.edoc.container-titlePLoS ONEnone
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0201693none
local.edoc.container-publisher-namePublic Library of Sciencenone
local.edoc.container-volume13none
local.edoc.container-issue8none
local.edoc.container-reportyear2018none
local.edoc.container-firstpage1none
local.edoc.container-lastpage9none
local.edoc.rki-departmentInfektionskrankheitennone
dc.description.versionPeer Reviewednone

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