Show simple item record

2018-07-06Zeitschriftenartikel DOI: 10.25646/5667
Implications of standardization of serum 25-hydroxyvitamin D data for the evaluation of vitamin D status in Germany, including a temporal analysis
dc.contributor.authorRabenberg, Martina
dc.contributor.authorScheidt-Nave, Christa
dc.contributor.authorBusch, Markus A.
dc.contributor.authorThamm, Michael
dc.contributor.authorRieckmann, Nina
dc.contributor.authorDurazo-Arvizu, Ramón A.
dc.contributor.authorDowling, Kirsten G.
dc.contributor.authorŠkrabáková, Zuzana
dc.contributor.authorCashman, Kevin D.
dc.contributor.authorSempos, Christopher T.
dc.contributor.authorMensink, Gert
dc.date.accessioned2018-09-11T14:55:30Z
dc.date.available2018-09-11T14:55:30Z
dc.date.issued2018-07-06none
dc.identifier.other10.1186/s12889-018-5769-y
dc.identifier.urihttp://edoc.rki.de/176904/5732
dc.description.abstractBackground: Comparability of 25-hydroxyvitamin D (25(OH)D) measurements is hampered by method-related differences in measurement values. International standardization of laboratory assays has been suggested to solve this problem. Methods: As part of the European Commission–funded project ‘Food-based solutions for optimal vitamin D nutrition and health through the life cycle’ (ODIN), original measurements of serum 25(OH)D of three German national health surveys conducted between 1998 and 2011 have been standardized retrospectively. In these representative population-based samples including persons aged between 1 and 79 years, the original 25(OH)D values were compared with those after standardization. Mean values and prevalences of vitamin D deficiency, insufficiency, and sufficiency (25(OH)D levels < 30, 30- < 50, and > =50 nmol/l, respectively) were calculated by sex and age groups based on original and standardized 25(OH)D data. Results: In comparison to the original 25(OH)D levels, the standardized levels showed higher means overall and in age- and sex-specific analyses. After standardization, the prevalence of vitamin D deficiency was lower in all surveys while the prevalence of vitamin D sufficiency was higher. Nevertheless, even after standardization ~ 15% of adults and 12.5% of children had serum 25(OH)D levels < 30 nmol/l. Thus, the proportion of deficient vitamin D levels in the German population is still considerable. Conclusions: The use of standardization of 25(OH)D levels has a substantial impact on estimates of the vitamin D status in Germany. Since clinical diagnostic, therapeutic and public health decision-making require valid and comparable data, standardization and calibration of commercial, clinical and research laboratory assays for 25(OH)D measurement should become common practice. Until then, researchers, health practitioners and policy makers should be aware of the peculiarities of the measurement methods when comparing and interpreting 25(OH)D levels.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subjectVitamin Deng
dc.subject25(OH)Deng
dc.subjectVitamin D deficiencyeng
dc.subjectStandardizationeng
dc.subjectComparabilityeng
dc.subjectPopulation survey, Germanyeng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleImplications of standardization of serum 25-hydroxyvitamin D data for the evaluation of vitamin D status in Germany, including a temporal analysisnone
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:0257-176904/5732-1
dc.identifier.doihttp://dx.doi.org/10.25646/5667
dc.type.versionpublishedVersionnone
local.edoc.container-titleBMC Public Healthnone
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://bmcpublichealth.biomedcentral.com/articles/10.1186/s12889-018-5769-ynone
local.edoc.container-publisher-nameBioMedCentralnone
local.edoc.container-volume18none
local.edoc.container-issue845none
local.edoc.container-firstpage1none
local.edoc.container-lastpage14none
local.edoc.rki-departmentEpidemiologie und Gesundheitsmonitoringnone
dc.description.versionPeer Reviewednone

Show simple item record