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2017-09-22Zeitschriftenartikel DOI: 10.25646/5673
Wild rodents and shrews are natural hosts of Staphylococcus aureus
dc.contributor.authorMrochen, Daniel M.
dc.contributor.authorSchulz, Daniel
dc.contributor.authorFischer, Stefan
dc.contributor.authorJeske, Kathrin
dc.contributor.authorEl Gohary, Heba
dc.contributor.authorReil, Daniela
dc.contributor.authorImholt, Christian
dc.contributor.authorTrübe, Patricia
dc.contributor.authorSuchomel, Josef
dc.contributor.authorTricaud, Emilie
dc.contributor.authorJacob, Jens
dc.contributor.authorHeroldová, Marta
dc.contributor.authorBröker, Barbara M.
dc.contributor.authorStrommenger, Birgit
dc.contributor.authorWalther, Birgit
dc.contributor.authorUlrich, Rainer G.
dc.contributor.authorHoltfreter, Silva
dc.date.accessioned2018-09-12T06:48:38Z
dc.date.available2018-09-12T06:48:38Z
dc.date.issued2017-09-22none
dc.identifier.other10.1016/j.ijmm.2017.09.014
dc.identifier.urihttp://edoc.rki.de/176904/5738
dc.description.abstractLaboratory mice are the most commonly used animal model for Staphylococcus aureus infection studies. We have previously shown that laboratory mice from global vendors are frequently colonized with S. aureus. Laboratory mice originate from wild house mice. Hence, we investigated whether wild rodents, including house mice, as well as shrews are naturally colonized with S. aureus and whether S. aureus adapts to the wild animal host. 295 animals of ten different species were caught in different locations over four years (2012–2015) in Germany, France and the Czech Republic. 45 animals were positive for S. aureus (15.3%). Three animals were co-colonized with two different isolates, resulting in 48 S. aureus isolates in total. Positive animals were found in Germany and the Czech Republic in each studied year. The S. aureus isolates belonged to ten different spa types, which grouped into six lineages (clonal complex (CC) 49, CC88, CC130, CC1956, sequence type (ST) 890, ST3033). CC49 isolates were most abundant (17/48, 35.4%), followed by CC1956 (14/48, 29.2%) and ST890 (9/48, 18.8%). The wild animal isolates lacked certain properties that are common among human isolates, e.g., a phage-encoded immune evasion cluster, superantigen genes on mobile genetic elements and antibiotic resistance genes, which suggests long-term adaptation to the wild animal host. One CC130 isolate contained the mecC gene, implying wild rodents might be both reservoir and vector for methicillin-resistant . In conclusion, we demonstrated that wild rodents and shrews are naturally colonized with S. aureus, and that those S. aureus isolates show signs of host adaptation.eng
dc.language.isogernone
dc.publisherRobert Koch-Institut
dc.rights(CC BY-NC-ND 3.0 DE) Namensnennung - Nicht-kommerziell - Keine Bearbeitung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/de/
dc.subjectStaphylococcus aureuseng
dc.subjectColonizationeng
dc.subjectWild miceeng
dc.subjectHost adaptationeng
dc.subjectImmune evasion clustereng
dc.subjectmecCeng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleWild rodents and shrews are natural hosts of Staphylococcus aureusnone
dc.typearticle
dc.identifier.urnurn:nbn:de:kobv:0257-176904/5738-5
dc.identifier.doihttp://dx.doi.org/10.25646/5673
dc.type.versionpublishedVersionnone
local.edoc.container-titleElsevier International Journal of Medical Microbiologynone
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://www.sciencedirect.com/science/article/pii/S1438422117303867?via%3Dihubnone
local.edoc.container-publisher-nameElseviernone
local.edoc.container-volume308none
local.edoc.container-issue6none
local.edoc.container-reportyear2018none
local.edoc.container-firstpage590none
local.edoc.container-lastpage597none
local.edoc.rki-departmentInfektionskrankheitennone
dc.description.versionPeer Reviewednone

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